SNCA Rep1 promoter variability influences cognition in Parkinson's disease

• Published in: Movement disorders Vol. 34; no. 8; pp. 1232 - 1236
• Main Authors: Ng, Adeline S.L., Tan, Yi Jayne, Zhao, Yi, Saffari, Seyed Ehsan, Lu, Zhonghao, Ng, Ebonne Y.L., Ng, Samuel Y.E., Chia, Nicole S.Y., Setiawan, Fiona, Xu, Zheyu, Tay, Kay Yaw, Au, Wing Lok, Tan, Louis C.S., Tan, Eng‐King
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2019; Wiley Subscription Services, Inc
• Subjects: Alleles; Apolipoproteins; cognition; Cognition & reasoning; Cognitive ability; genetics; Genotypes; Movement disorders; Neurodegenerative diseases; Parkinson's disease; SNCA Rep1 promoter; Synuclein; Parkinson's disease; genetics; cognition; SNCA Rep1 promoter

Background While the association between alpha‐synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is unclear. Objectives To investigate the association between Rep1 and motor and cognitive outcomes in PD. Methods Rep1 allele lengths were det...