SNCA Rep1 promoter variability influences cognition in Parkinson's disease
Background While the association between alpha‐synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is unclear. Objectives To investigate the association between Rep1 and motor and cognitive outcomes in PD. Methods Rep1 allele lengths were det...
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| Published in | Movement disorders Vol. 34; no. 8; pp. 1232 - 1236 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken, USA
John Wiley & Sons, Inc
01.08.2019
Wiley Subscription Services, Inc |
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| Online Access | Get full text |
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| Abstract | Background
While the association between alpha‐synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is unclear.
Objectives
To investigate the association between Rep1 and motor and cognitive outcomes in PD.
Methods
Rep1 allele lengths were determined in 172 PD patients who were grouped into “long” and “short” carriers according to previous methods. Multivariable regression analysis was performed to investigate the effect of Rep1 length on cognitive and motor scores.
Results
Long Rep1 allele carriers had significantly lower MMSE (P = 0.010) and higher UPDRS Part III (P = 0.026) and H & Y (P = 0.008) scores compared to short allele carriers (controlled for age, sex, and disease duration). Interaction analyses of Rep1 with apolipoprotein 4 revealed no significant effect on clinical outcomes.
Conclusions
PD patients carrying long Rep1 alleles are more impaired on cognitive and motor function independent of apolipoprotein 4 genotype. © 2019 International Parkinson and Movement Disorder Society |
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| AbstractList | BACKGROUNDWhile the association between alpha-synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is unclear. OBJECTIVESTo investigate the association between Rep1 and motor and cognitive outcomes in PD. METHODSRep1 allele lengths were determined in 172 PD patients who were grouped into "long" and "short" carriers according to previous methods. Multivariable regression analysis was performed to investigate the effect of Rep1 length on cognitive and motor scores. RESULTSLong Rep1 allele carriers had significantly lower MMSE (P = 0.010) and higher UPDRS Part III (P = 0.026) and H & Y (P = 0.008) scores compared to short allele carriers (controlled for age, sex, and disease duration). Interaction analyses of Rep1 with apolipoprotein 4 revealed no significant effect on clinical outcomes. CONCLUSIONSPD patients carrying long Rep1 alleles are more impaired on cognitive and motor function independent of apolipoprotein 4 genotype. © 2019 International Parkinson and Movement Disorder Society. BackgroundWhile the association between alpha‐synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is unclear.ObjectivesTo investigate the association between Rep1 and motor and cognitive outcomes in PD.MethodsRep1 allele lengths were determined in 172 PD patients who were grouped into “long” and “short” carriers according to previous methods. Multivariable regression analysis was performed to investigate the effect of Rep1 length on cognitive and motor scores.ResultsLong Rep1 allele carriers had significantly lower MMSE (P = 0.010) and higher UPDRS Part III (P = 0.026) and H & Y (P = 0.008) scores compared to short allele carriers (controlled for age, sex, and disease duration). Interaction analyses of Rep1 with apolipoprotein 4 revealed no significant effect on clinical outcomes.ConclusionsPD patients carrying long Rep1 alleles are more impaired on cognitive and motor function independent of apolipoprotein 4 genotype. © 2019 International Parkinson and Movement Disorder Society While the association between alpha-synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is unclear. To investigate the association between Rep1 and motor and cognitive outcomes in PD. Rep1 allele lengths were determined in 172 PD patients who were grouped into "long" and "short" carriers according to previous methods. Multivariable regression analysis was performed to investigate the effect of Rep1 length on cognitive and motor scores. Long Rep1 allele carriers had significantly lower MMSE (P = 0.010) and higher UPDRS Part III (P = 0.026) and H & Y (P = 0.008) scores compared to short allele carriers (controlled for age, sex, and disease duration). Interaction analyses of Rep1 with apolipoprotein 4 revealed no significant effect on clinical outcomes. PD patients carrying long Rep1 alleles are more impaired on cognitive and motor function independent of apolipoprotein 4 genotype. © 2019 International Parkinson and Movement Disorder Society. Background While the association between alpha‐synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is unclear. Objectives To investigate the association between Rep1 and motor and cognitive outcomes in PD. Methods Rep1 allele lengths were determined in 172 PD patients who were grouped into “long” and “short” carriers according to previous methods. Multivariable regression analysis was performed to investigate the effect of Rep1 length on cognitive and motor scores. Results Long Rep1 allele carriers had significantly lower MMSE (P = 0.010) and higher UPDRS Part III (P = 0.026) and H & Y (P = 0.008) scores compared to short allele carriers (controlled for age, sex, and disease duration). Interaction analyses of Rep1 with apolipoprotein 4 revealed no significant effect on clinical outcomes. Conclusions PD patients carrying long Rep1 alleles are more impaired on cognitive and motor function independent of apolipoprotein 4 genotype. © 2019 International Parkinson and Movement Disorder Society |
| Author | Xu, Zheyu Ng, Ebonne Y.L. Zhao, Yi Tan, Eng‐King Au, Wing Lok Tan, Yi Jayne Tay, Kay Yaw Setiawan, Fiona Lu, Zhonghao Ng, Samuel Y.E. Ng, Adeline S.L. Chia, Nicole S.Y. Tan, Louis C.S. Saffari, Seyed Ehsan |
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| Cites_doi | 10.1002/ana.24777 10.1212/WNL.17.5.427 10.1093/hmg/10.26.3101 10.1016/S1474-4422(12)70152-7 10.1016/0022-3956(75)90026-6 10.1093/hmg/ddl030 10.1016/j.jns.2011.07.047 10.1002/mds.10473 10.1126/science.1090278 10.1093/hmg/ddp265 10.1371/journal.pone.0007480 10.1002/mds.20752 10.1002/ana.24664 10.1038/nrneurol.2017.27 10.1096/fj.07-9348com 10.1002/ana.21966 10.1515/cclm.2002.197 10.1016/S0304-3940(02)01178-3 10.1093/brain/awu201 10.3389/fneur.2018.00213 10.1136/jnnp-2013-305277 10.1001/jamaneurol.2014.1455 10.1093/hmg/10.17.1847 10.1016/j.parkreldis.2014.02.021 10.1371/journal.pone.0036199 10.1002/ana.20268 10.1002/ana.22499 10.1001/jama.296.6.661 10.1212/01.WNL.0000101721.25345.DC |
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While the association between alpha‐synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is... While the association between alpha-synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is unclear.... BackgroundWhile the association between alpha‐synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is... BACKGROUNDWhile the association between alpha-synuclein gene promoter (Rep1) variability and risk of PD is well established, its association with cognition is... |
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| SubjectTerms | Alleles Apolipoproteins cognition Cognition & reasoning Cognitive ability genetics Genotypes Movement disorders Neurodegenerative diseases Parkinson's disease SNCA Rep1 promoter Synuclein |
| Title | SNCA Rep1 promoter variability influences cognition in Parkinson's disease |
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