Targeting ferroptosis alleviates methionine‐choline deficient (MCD)‐diet induced NASH by suppressing liver lipotoxicity

• Published in: Liver international Vol. 40; no. 6; pp. 1378 - 1394
• Main Authors: Li, Xiaoya, Wang, Tian‐Xiang, Huang, Xinmei, Li, Yue, Sun, Tiange, Zang, Shufei, Guan, Kun‐Liang, Xiong, Yue, Liu, Jun, Yuan, Hai‐Xin
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2020
• Subjects: Accumulation; Apoptosis; Arachidonic acid; Cell culture; Cell death; Choline; Diet; Droplets; Drug therapy; Electron microscopy; Fatty liver; Ferroptosis; Gene expression; Health services; Inhibitors; Iron; Lipid peroxidation; lipid ROS; Lipids; Liver; Liver diseases; Medical treatment; Metabolism; Methionine; Mitochondria; NASH; Nutrient deficiency; Peroxidation; Peroxides; Ribonucleic acid; RNA; Scavenging; Steatosis; Therapeutic applications; ferroptosis; NASH; lipid ROS; steatosis

Background NASH is one of the fastest growing liver diseases that leads to severe steatosis, inflammation and ultimately liver injury. However, the pathophysiological mechanisms of NASH remain unclear and pharmacological treatment against the disease is unavailable currently. Ferroptosis is a non‐ap...