Choroid Plexus Enlargement Exacerbates White Matter Hyperintensity Growth through Glymphatic Impairment

• Published in: Annals of neurology Vol. 94; no. 1; pp. 182 - 195
• Main Authors: Li, Yifei, Zhou, Ying, Zhong, Wansi, Zhu, Xiao, Chen, Yuping, Zhang, Kemeng, He, Yaode, Luo, Zhongyu, Ran, Wang, Sun, Jianzhong, Lou, Min
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.07.2023; Wiley Subscription Services, Inc
• Subjects: Brain; Brain - pathology; Cerebrospinal fluid; Choroid plexus; Choroid Plexus - diagnostic imaging; Contrast agents; Contrast media; Humans; Image analysis; Image processing; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Neuroimaging; Pathogenesis; Prospective Studies; Retrospective Studies; Substantia alba; Tensors; Ventricle (lateral); White Matter - diagnostic imaging; White Matter - pathology

Objective Choroid plexus (CP) is a key regulator in cerebrospinal fluid production, but its contribution to glymphatic clearance function and association with white matter hyperintensity (WMH) remains unclear. Methods This retrospective study included 2 prospective 3.0‐T magnetic resonance imaging (...