Circulating Apoptotic Microparticles in Systemic Lupus Erythematosus Patients Drive the Activation of Dendritic Cell Subsets and Prime Neutrophils for NETosis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 68; no. 2; pp. 462 - 472
• Main Authors: Dieker, Jürgen, Tel, Jurjen, Pieterse, Elmar, Thielen, Astrid, Rother, Nils, Bakker, Marinka, Fransen, Jaap, Dijkman, Henry B. P. M., Berden, Jo H., de Vries, Jolanda M., Hilbrands, Luuk B., van der Vlag, Johan
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.02.2016
• Subjects: Annexin A5 - metabolism; Antigens, CD - metabolism; Apoptosis - immunology; Arthritis, Rheumatoid - immunology; Autoimmune diseases; B7-1 Antigen - metabolism; B7-2 Antigen - metabolism; Case-Control Studies; CD40 Antigens - metabolism; CD83 Antigen; Cell Adhesion Molecules - metabolism; Cell-Derived Microparticles - immunology; Cell-Derived Microparticles - metabolism; Dendritic Cells - immunology; Enzyme-Linked Immunosorbent Assay; Extracellular Traps - immunology; Flow Cytometry; GPI-Linked Proteins - metabolism; Humans; Immunoglobulins - metabolism; Interferon-alpha - immunology; Interleukin-6 - immunology; Leukocyte Common Antigens - metabolism; Lupus; Lupus Erythematosus, Systemic - immunology; Membrane Glycoproteins - metabolism; Microscopy, Fluorescence; Neutrophils; Neutrophils - immunology; Platelet Endothelial Cell Adhesion Molecule-1 - metabolism; Rodents; Scleroderma, Systemic - immunology; Tumor Necrosis Factor-alpha - immunology

Objective Circulating chromatin‐containing apoptotic material and/or neutrophil extracellular traps (NETs) have been proposed to be an important driving force for the antichromatin autoimmune response in patients with systemic lupus erythematosus (SLE). The aim of this study was to determine the exa...