miR‐188‐5p suppresses cellular proliferation and migration via IL6ST: A potential noninvasive diagnostic biomarker for breast cancer

• Published in: Journal of cellular physiology Vol. 235; no. 5; pp. 4890 - 4901
• Main Authors: Wang, Mei, Zhang, Huiling, Yang, Fang, Qiu, Rong, Zhao, Xinxin, Gong, Zheng, Yu, Wanjun, Zhou, Baocheng, Shen, Bo, Zhu, Wei
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2020
• Subjects: Biomarkers; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Biopsy; Breast cancer; Breast Neoplasms - blood; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Case-Control Studies; Cell migration; Cell Movement; Cell Proliferation; Circulating MicroRNA - blood; Circulating MicroRNA - genetics; Cytokine Receptor gp130 - genetics; Cytokine Receptor gp130 - metabolism; Diagnostic systems; Exosomes; Exosomes - genetics; Exosomes - metabolism; Exosomes - pathology; Female; Fibroadenoma; Fibroadenoma - blood; Fibroadenoma - genetics; Gene Expression Regulation, Neoplastic; Humans; IL6ST; Interleukin 6; Lymph nodes; MCF-7 Cells; Metastases; MicroRNAs - blood; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miR‐188‐5p; Neoplasm Invasiveness; Polymerase chain reaction; Predictive Value of Tests; Prognosis; Regulatory mechanisms (biology); serum; Signal Transduction; Therapeutic applications; tumor suppressor; Tumor Suppressor Proteins - blood; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; breast cancer; tumor suppressor; miR-188-5p; IL6ST; serum

Previously, serum miR‐188‐5p is differentially expressed in breast cancer, but the diagnostic potential of circulating miR‐188‐5p as well as its regulatory mechanism in breast cancer remain uncertain. Herein, serum miR‐188‐5p was detected by real‐time polymerase chain reaction in patients with breas...