The Role of Innate Immune Cells in Nonalcoholic Steatohepatitis

• Published in: Hepatology (Baltimore, Md.) Vol. 70; no. 3; pp. 1026 - 1037
• Main Authors: Cai, Jingjing, Zhang, Xiao‐Jing, Li, Hongliang
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.09.2019
• Subjects: Dendritic cells; Endothelial cells; Fibrosis; Hepatocytes; Hepatology; Inflammation; Innate immunity; Insulin; Kupffer cells; Liver diseases; Lymphocytes; Metabolism; Metabolites

Inflammation and metabolic dysfunction are hallmarks of nonalcoholic steatohepatitis (NASH), which is one of the fastest‐growing liver diseases worldwide. Emerging evidence indicates that innate immune mechanisms are pivotal drivers of inflammation and other pathological manifestations observed in N...