Immune response towards the amino-terminus of desmoglein 1 prevails across different activity stages in nonendemic pemphigus foliaceus

• Published in: British journal of dermatology (1951) Vol. 162; no. 6; pp. 1242 - 1250
• Main Authors: Chan, P.T., Ohyama, B., Nishifuji, K., Yoshida, K., Ishii, K., Hashimoto, T., Amagai, M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2010; Wiley-Blackwell
• Subjects: Autoantibodies - immunology; Biological and medical sciences; Bullous diseases of the skin; Dermatology; desmoglein 1; Desmoglein 1 - chemistry; Desmoglein 1 - immunology; Desmoglein 2 - chemistry; Desmoglein 2 - immunology; Enzyme-Linked Immunosorbent Assay; epitopes; Epitopes - immunology; Follow-Up Studies; Humans; Immunoblotting; Immunoprecipitation; Medical sciences; Pemphigus - blood; Pemphigus - immunology; Pemphigus - physiopathology; pemphigus foliaceus; Recombinant Proteins - immunology; Recombinant Proteins - metabolism; Severity of Illness Index; Bullous dermatosis; Immunopathology; epitopes; Skin disease; desmoglein 1; pemphigus foliaceus; Immune response; Antigenic determinant; Dermatology; Pemphigus foliaceous; Autoimmune disease

Summary Background  Pemphigus foliaceus (PF) is a blistering skin disease mediated by antibodies to desmoglein (Dsg) 1. The two major subtypes are nonendemic and endemic PF. A previous study in endemic PF demonstrated that changes in antibody epitope could modulate disease relapse and remission. Obj...