Fiber‐specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis

• Published in: European journal of neurology Vol. 29; no. 2; pp. 432 - 440
• Main Authors: Ogura, Aya, Kawabata, Kazuya, Watanabe, Hirohisa, Choy, Shao Wei, Bagarinao, Epifanio, Kato, Toshiyasu, Imai, Kazunori, Masuda, Michihito, Ohdake, Reiko, Hara, Kazuhiro, Nakamura, Ryoichi, Atsuta, Naoki, Nakamura, Tomohiko, Katsuno, Masahisa, Sobue, Gen
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2022
• Subjects: Amyotrophic lateral sclerosis; Brain; Corpus callosum; corticospinal tract; diffusion‐weighted imaging; Error correction; fixel‐based analysis; Morphometry; Neuroimaging; Patients; Pyramidal tracts; Reduction; Substantia alba; upper motor neuron signs; fixel-based analysis; upper motor neuron signs; diffusion-weighted imaging; amyotrophic lateral sclerosis; corticospinal tract

Background and purpose To clarify the relationship between fiber‐specific white matter changes in amyotrophic lateral sclerosis (ALS) and clinical signs of upper motor neuron (UMN) involvement, we performed a fixel‐based analysis (FBA), a novel framework for diffusion‐weighted imaging analysis. Meth...