Neural representation of prediction error signals in substance users

• Published in: Addiction biology Vol. 26; no. 3; pp. e12976 - n/a
• Main Authors: Tolomeo, Serenella, Yaple, Zachary A., Yu, Rongjun
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.05.2021
• Subjects: addiction; Clinical decision making; Decision making; fMRI; Frontal gyrus; Mesencephalon; Meta-analysis; Neostriatum; Neural coding; prediction error signals; Predictions; Putamen; striatum; Substance use; substance use; meta-analysis; fMRI; prediction error signals; striatum; addiction
• ISSN: 1355-6215; 1369-1600; 1369-1600
• DOI: 10.1111/adb.12976

Abnormal decision making can result in detrimental outcomes of clinical importance, and decision making is strongly linked to neural prediction error signalling. Activation likelihood estimation (ALE) meta‐analyses were used to examine the neural correlates of prediction error signals of individuals taking different types of substances and healthy controls with contrast and conjunction analyses. Twenty‐eight studies were included in the meta‐analysis, representing 424 substance users' individuals and 834 healthy control individuals. Robust brain activity associated with prediction error signals in substance users was found for the bilateral striatum and insula. Healthy control subjects also activated bilateral striatum, midbrain, right insula and right medial‐inferior frontal gyrus. Compared with healthy controls, substance users showed blunted activity in the bilateral putamen, right medial‐inferior frontal gyrus and insula. The current meta‐analysis of cross‐sectional findings investigated neural prediction error signals in substance users. PE abnormalities in substance users might be related to poor decision making. In conclusion, the present study helps identify the pathophysiological underpinnings of maladaptive decision making in substance users. Substance use is a complex, multifaceted and behavioural condition. To our knowledge, this is the first study to conduct a large‐scale meta‐analysis of fMRI studies on PE abnormalities in substance use. The current study revealed bilateral PE striatal activation in substance users, which was significantly smaller than healthy controls. In addition, we found that substance users revealed blunted PE signals in comparison with healthy controls in the bilateral putamen, insula and frontal gyrus across studies. Finally, we found a significant interaction effect of Group and Age specifically within the bilateral striatum for the healthy control group, but not for the substance user group, perhaps as a result of diminished PE signals in the striatum activation in older ages.