Radiosynthesis and characterization of a carbon-11 PET tracer for receptor-interacting protein kinase 1

• Published in: Nuclear medicine and biology Vol. 110-111; pp. 18 - 27
• Main Authors: Huang, Tianyu, Gu, Jiwei, Jiang, Hao, Liang, Qianwa, Perlmutter, Joel S., Tu, Zhude
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2022; Elsevier BV
• Subjects: Amyotrophic lateral sclerosis; Animals; Autoradiography; Biodistribution; Brain; Brain - metabolism; Carbon Radioisotopes; Carbon-11 radioligand; Cell death; Decay; Immunodeficiency; Immunohistochemistry; In vivo methods and tests; Inflammation; Inflammation - diagnostic imaging; Inflammation - metabolism; Inflammatory response; Iodides; Kidneys; Kinases; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Liver; Methylation; Mice; Mice, Inbred C57BL; Multiple sclerosis; Necroptosis; Neurodegenerative diseases; Neurodegenerative Diseases - metabolism; PET imaging; Positron emission tomography; Positron-Emission Tomography - methods; Protein kinase; Protein Kinases - metabolism; Proteins; Purity; Radioactive tracers; Radiochemistry; Rats; Rats, Sprague-Dawley; Receptors; RIPK1; Rodents; Spleen; Tissue Distribution; White pulp; Spleen; RIPK1; Inflammation; PET imaging; Carbon-11 radioligand; Lipopolysaccharides

Receptor-interacting protein kinase 1 (RIPK1) has emerged as a crucial regulator of necroptosis and the inflammatory response by activating a group of downstream immune receptors. It has been recognized as a pivotal contributor to cell death and inflammation in various physiological and pathological...