Global DNA 5‐Hydroxymethylcytosine and 5‐Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma

• Published in: Hepatology (Baltimore, Md.) Vol. 69; no. 1; pp. 196 - 208
• Main Authors: Liu, Jiao, Jiang, Jinhua, Mo, Jiezhen, Liu, Dan, Cao, Dan, Wang, Hailin, He, Yufei, Wang, Hongyang
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.01.2019
• Subjects: 5-Methylcytosine - analogs & derivatives; 5-Methylcytosine - analysis; Carcinoma, Hepatocellular - chemistry; Carcinoma, Hepatocellular - pathology; Cytosine; Cytosine - analogs & derivatives; Cytosine - analysis; Deoxyribonucleic acid; DNA; DNA methylation; DNA, Neoplasm - analysis; Enzymatic activity; Enzymes; Female; Genomes; Hepatitis B; Hepatocellular carcinoma; Hepatology; Humans; Ketoglutaric acid; Liver cancer; Liver Neoplasms - chemistry; Liver Neoplasms - pathology; Male; Middle Aged; Neoplasm Staging

Methylation of the fifth position of cytosine (5mC) is an important epigenetic modification of DNA. It has been shown that the oxidized derivatives of 5mC, namely 5‐hydroxymethylcytosine (5hmC), 5‐formylcytosine (5fC), and 5‐carboxylcytosine (5caC), are in dynamic existence and have distinct regulat...