Postoperative ileus—An ongoing conundrum

• Published in: Neurogastroenterology and motility Vol. 33; no. 5; pp. e14046 - n/a
• Main Authors: Wattchow, David, Heitmann, Paul, Smolilo, David, Spencer, Nick J., Parker, Dominic, Hibberd, Timothy, Brookes, Simon S. J., Dinning, Phil G., Costa, Marcello
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2021
• Subjects: Anesthesia, Epidural; Animal models; Animals; Benzofurans - therapeutic use; Chewing Gum; Cholinergic Agents - therapeutic use; Contrast Media - therapeutic use; Cyclooxygenase Inhibitors - therapeutic use; Diatrizoate Meglumine - therapeutic use; Digestive System Surgical Procedures - methods; Enhanced Recovery After Surgery; Enteral Nutrition; Enteric Nervous System - physiopathology; Fluid Therapy; Gastrointestinal Agents - therapeutic use; Gastrointestinal Motility - physiology; Ghrelin - therapeutic use; Humans; ileus; Ileus - immunology; Ileus - physiopathology; Ileus - prevention & control; Ileus - therapy; Inflammation - immunology; intestinal nervous system; Intestinal Pseudo-Obstruction - immunology; Intestinal Pseudo-Obstruction - physiopathology; Intestinal Pseudo-Obstruction - prevention & control; Intestinal Pseudo-Obstruction - therapy; Intubation, Gastrointestinal; Laboratory animals; Laparoscopy; Mast Cells - immunology; Piperidines - therapeutic use; postoperative; Postoperative Complications - immunology; Postoperative Complications - physiopathology; Postoperative Complications - prevention & control; Postoperative Complications - therapy; Serotonin 5-HT4 Receptor Agonists - therapeutic use; Sympathetic Nervous System - physiopathology; Sympatholytics - therapeutic use; postoperative; ileus; intestinal nervous system

Background Postoperative ileus is common and is a major clinical problem. It has been widely studied in patients and in experimental models in laboratory animals. A wide variety of treatments have been tested to prevent or modify the course of this disorder. Purpose This review draws together inform...