An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

• Published in: Journal of cellular physiology Vol. 234; no. 5; pp. 5451 - 5465
• Main Authors: Saliminejad, Kioomars, Khorram Khorshid, Hamid Reza, Soleymani Fard, Shahrzad, Ghaffari, Seyed Hamidollah
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2019
• Subjects: Animals; Apoptosis; Bioinformatics; Cancer; Cell Communication; Cell interactions; Computational Biology; Epigenesis, Genetic; Epigenetics; Exercise; Gene expression; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Humans; intercellular communication; microRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; MicroRNAs - therapeutic use; miRNA; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - therapy; Post-transcription; Regulators; Ribonucleic acid; RNA; Signal Transduction; therapeutics; intercellular communication; microRNA; therapeutics; epigenetics; gene expression

MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis. They have been linked to many diseases, and cur...