Reactive oxygen species and colorectal cancer

• Published in: Journal of cellular physiology Vol. 233; no. 7; pp. 5119 - 5132
• Main Authors: Lin, Sisi, Li, Yongyu, Zamyatnin, Andrey A., Werner, Jens, Bazhin, Alexandr V.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2018
• Subjects: Apoptosis; Cancer; Cell death; Colorectal cancer; Colorectal carcinoma; Deoxyribonucleic acid; DNA; DNA damage; Drug resistance; Mortality; Reactive oxygen species; Roles; Side effects; Signaling; Therapeutic applications; Therapy; tumor microenvironment; Tumors; colorectal cancer; reactive oxygen species; tumor microenvironment

Colorectal cancer (CRC) has become the fourth leading cause of cancer‐related death in the worldwide. It is urgent to find more effective therapeutic strategies for it. Reactive oxygen species (ROS) play multiple roles in normal cellular physiology processes. Thus, a certain level of ROS is essentia...