Sexual dimorphism of estrogen‐sensitized synoviocytes contributes to gender difference in temporomandibular joint osteoarthritis

• Published in: Oral diseases Vol. 24; no. 8; pp. 1503 - 1513
• Main Authors: Xue, Xin‐Tong, Zhang, Ting, Cui, Sheng‐Jie, He, Dan‐Qing, Wang, Xue‐Dong, Yang, Rui‐Li, Liu, Da‐Wei, Liu, Yan, Gan, Ye‐Hua, Kou, Xiao‐Xing, Zhou, Yan‐Heng
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.11.2018
• Subjects: Animals; Antigens, CD - metabolism; Antigens, Differentiation, Myelomonocytic - metabolism; Arthritis; Cartilage diseases; Cell Movement - drug effects; Cells, Cultured; Chemokine CCL2 - metabolism; estrogen; Estrogen Receptor Antagonists - pharmacology; Estrogens - metabolism; Estrogens - pharmacology; Female; Immunohistochemistry; Inflammation; Interleukin-1beta - metabolism; Leukocyte migration; Macrophages; Macrophages - metabolism; Macrophages - physiology; Male; Nitric Oxide Synthase Type II - metabolism; Nitric-oxide synthase; Osteoarthritis; Osteoarthritis - metabolism; Osteoarthritis - pathology; Ovariectomy; Rats; Rats, Sprague-Dawley; Receptors, Estrogen - antagonists & inhibitors; Rodents; Sex differences; Sex Factors; Sexual dimorphism; Synovial membrane; Synovial Membrane - metabolism; Synoviocytes; Synoviocytes - drug effects; Synoviocytes - metabolism; synovitis; Temporomandibular joint; Temporomandibular Joint Disorders - metabolism; Temporomandibular joint osteoarthritis; Tumor necrosis factor; Tumor Necrosis Factor-alpha - pharmacology; estrogen; Temporomandibular joint osteoarthritis; sexual dimorphism; synovitis

Objectives Temporomandibular joint osteoarthritis (TMJOA) is approximately twice as prevalent in women than in men. Synoviocytes are believed to play a critical role in joint inflammation. However, it is unknown whether synoviocytes from different genders possess sexual dimorphisms that contribute t...