Liver transplantation for children with acute liver failure associated with secondary hemophagocytic lymphohistiocytosis

• Published in: Liver transplantation Vol. 22; no. 9; pp. 1245 - 1253
• Main Authors: Amir, Achiya Z., Ling, Simon C., Naqvi, Ahmed, Weitzman, Sheila, Fecteau, Annie, Grant, David, Ghanekar, Anand, Cattral, Mark, Nalli, Nadya, Cutz, Ernest, Kamath, Binita, Jones, Nicola, Angelis, Maria, Ng, Vicky, Avitzur, Yaron
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2016
• Subjects: Adolescent; Biopsy; Child; Child, Preschool; Cross-Sectional Studies; Disease Progression; Female; Ferritins - blood; Fibrinogen - analysis; Graft Rejection - prevention & control; Humans; Immunosuppression - methods; Immunosuppressive Agents - therapeutic use; Infant; Liver; Liver - pathology; Liver Failure, Acute - blood; Liver Failure, Acute - etiology; Liver Failure, Acute - mortality; Liver Failure, Acute - surgery; Liver Transplantation; Lymphohistiocytosis, Hemophagocytic - complications; Lymphohistiocytosis, Hemophagocytic - diagnosis; Lymphohistiocytosis, Hemophagocytic - mortality; Male; Rare Diseases - complications; Recurrence; Retrospective Studies; Survival Rate; Time-to-Treatment; Treatment Outcome; Triglycerides - blood

Hemophagocytic lymphohistiocytosis (HLH) is a rare life‐threatening systemic disease, characterized by overwhelming stimulation of the immune system and categorized as primary or secondary types. Occasionally, acute liver failure (ALF) may dominate the clinical presentation. Given the systemic natur...