13q deletion is linked to an adverse phenotype and poor prognosis in prostate cancer

• Published in: Genes chromosomes & cancer Vol. 57; no. 10; pp. 504 - 512
• Main Authors: Kluth, Martina, Scherzai, Sekander, Büschek, Franziska, Fraune, Christoph, Möller, Katharina, Höflmayer, Doris, Minner, Sarah, Göbel, Cosima, Möller‐Koop, Christina, Hinsch, Andrea, Neubauer, Emily, Tsourlakis, Maria Christina, Sauter, Guido, Heinzer, Hans, Graefen, Markus, Wilczak, Waldemar, Luebke, Andreas M, Burandt, Eike, Steurer, Stefan, Schlomm, Thorsten, Simon, Ronald
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.10.2018; Wiley Subscription Services, Inc
• Subjects: 13q deletion; Adult; Aged; Biomarkers, Tumor - genetics; Biopsy; Chromosome 13; Chromosome Deletion; Chromosomes, Human, Pair 13 - genetics; DNA microarrays; Fluorescence; Fluorescence in situ hybridization; Gene Deletion; Humans; In Situ Hybridization, Fluorescence; Lymph nodes; Male; Metastases; Middle Aged; NADH, NADPH Oxidoreductases - genetics; Neoplasm Grading; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - pathology; phenotype; Phenotypes; Prognosis; Prostate cancer; Prostate-Specific Antigen - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Retina; Retinoblastoma; Retinoblastoma protein; Retinoblastoma Protein - genetics; Tissue Array Analysis; TMA; Tumors; phenotype; TMA; prostate cancer; 13q deletion; prognosis

Deletions of chromosome arm 13q belong to the most frequent molecular alterations in prostate cancer. To better understand the role of 13q deletion in prostate cancer we took advantage of our large prostate cancer tissue microarray comprising more than 12 000 cancer samples with full pathological an...