Global differences in atopic dermatitis

Atopic dermatitis (AD) is a chronic inflammatory skin disorder, with a highly variable prevalence worldwide. Recent evidence, however, has shown an increase in prevalence in the Asia Pacific region. Nevertheless, most of the published literature has focused mainly on Western populations, and only fe...

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Published inPediatric allergy and immunology Vol. 32; no. 1; pp. 23 - 33
Main Authors Suaini, Noor H. A., Tan, Cheryl P. T., Loo, Evelyn X. L., Tham, Elizabeth Huiwen, Eigenmann, Philippe
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.01.2021
Subjects
Asia
Atopic dermatitis
child
Clinical trials
Dermatitis
Eczema
environment
Environmental factors
ethnic diversity
genetics
global
immuno‐phenotypes
Phenotypes
Skin diseases
tailored treatment
environment
genetics
immuno-phenotypes
Asia
eczema
atopic dermatitis
tailored treatment
global
child
ethnic diversity
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Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disorder, with a highly variable prevalence worldwide. Recent evidence, however, has shown an increase in prevalence in the Asia Pacific region. Nevertheless, most of the published literature has focused mainly on Western populations, and only few clinical trials have included subgroups of other ethnic populations. Reasons for the observed ethnic and geographical differences in AD are not well established. This calls into question the need for a better understanding of AD pathogenesis and inter‐ethnic differences in clinical and immuno‐phenotypes. These differences may reflect inherent variability in disease mechanisms between populations, which in turn may impact upon treatment responses such as biologics that are currently tailored mainly to a specific immuno‐phenotype (T‐helper type 2 dominant). In this article, we reviewed existing literature on the prevalence of AD globally, highlighting differences, if any, in the clinical and immuno‐phenotypes of AD between different ethnicities. We discussed genetic and environmental factors that affect AD in different populations and therapeutic considerations. Our review highlights AD as a disease with ethnic‐dependent clinical and immunological heterogeneity and calls for greater inclusion of ethnic diversity in future research in order to develop targeted treatments.
AbstractList Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disorder, with a highly variable prevalence worldwide. Recent evidence, however, has shown an increase in prevalence in the Asia Pacific region. Nevertheless, most of the published literature has focused mainly on Western populations, and only few clinical trials have included subgroups of other ethnic populations. Reasons for the observed ethnic and geographical differences in AD are not well established. This calls into question the need for a better understanding of AD pathogenesis and inter‐ethnic differences in clinical and immuno‐phenotypes. These differences may reflect inherent variability in disease mechanisms between populations, which in turn may impact upon treatment responses such as biologics that are currently tailored mainly to a specific immuno‐phenotype (T‐helper type 2 dominant). In this article, we reviewed existing literature on the prevalence of AD globally, highlighting differences, if any, in the clinical and immuno‐phenotypes of AD between different ethnicities. We discussed genetic and environmental factors that affect AD in different populations and therapeutic considerations. Our review highlights AD as a disease with ethnic‐dependent clinical and immunological heterogeneity and calls for greater inclusion of ethnic diversity in future research in order to develop targeted treatments.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder, with a highly variable prevalence worldwide. Recent evidence, however, has shown an increase in prevalence in the Asia Pacific region. Nevertheless, most of the published literature has focused mainly on Western populations, and only few clinical trials have included subgroups of other ethnic populations. Reasons for the observed ethnic and geographical differences in AD are not well established. This calls into question the need for a better understanding of AD pathogenesis and inter-ethnic differences in clinical and immuno-phenotypes. These differences may reflect inherent variability in disease mechanisms between populations, which in turn may impact upon treatment responses such as biologics that are currently tailored mainly to a specific immuno-phenotype (T-helper type 2 dominant). In this article, we reviewed existing literature on the prevalence of AD globally, highlighting differences, if any, in the clinical and immuno-phenotypes of AD between different ethnicities. We discussed genetic and environmental factors that affect AD in different populations and therapeutic considerations. Our review highlights AD as a disease with ethnic-dependent clinical and immunological heterogeneity and calls for greater inclusion of ethnic diversity in future research in order to develop targeted treatments.
Author Loo, Evelyn X. L.
Eigenmann, Philippe
Suaini, Noor H. A.
Tan, Cheryl P. T.
Tham, Elizabeth Huiwen
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  givenname: Cheryl P. T.
  surname: Tan
  fullname: Tan, Cheryl P. T.
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Issue 1
Keywords environment
genetics
immuno-phenotypes
Asia
eczema
atopic dermatitis
tailored treatment
global
child
ethnic diversity
Language English
License 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
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Notes Funding information
Tham EH is supported by the National Medical Research Council (NMRC) Transition Award grant [MOH‐TA18nov‐003].
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Snippet Atopic dermatitis (AD) is a chronic inflammatory skin disorder, with a highly variable prevalence worldwide. Recent evidence, however, has shown an increase in...
Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disorder, with a highly variable prevalence worldwide. Recent evidence, however, has shown an...
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SubjectTerms Asia
Atopic dermatitis
child
Clinical trials
Dermatitis
Eczema
environment
Environmental factors
ethnic diversity
genetics
global
immuno‐phenotypes
Phenotypes
Skin diseases
tailored treatment
Title Global differences in atopic dermatitis
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fpai.13335
https://www.ncbi.nlm.nih.gov/pubmed/32841425
https://www.proquest.com/docview/2474453602
Volume 32
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