Characterization of pediatric hepatocellular carcinoma reveals genomic heterogeneity and diverse signaling pathway activation

• Published in: Pediatric blood & cancer Vol. 66; no. 7; pp. e27745 - n/a
• Main Authors: Haines, Katherine, Sarabia, Stephen F., Alvarez, Karla R., Tomlinson, Gail, Vasudevan, Sanjeev A., Heczey, Andras A., Roy, Angshumoy, Finegold, Milton J., Parsons, D. Williams, Plon, Sharon E., López‐Terrada, Dolores
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2019
• Subjects: Activation; Adenomatous polyposis coli; Adolescent; Adult; Brain tumors; cancer; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - therapy; Child; Child, Preschool; Children; Female; Genes; Hematology; Heparan sulfate proteoglycans; Hepatocellular carcinoma; Heterogeneity; Humans; Liver; Liver cancer; Liver diseases; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Liver Neoplasms - therapy; Male; MAP kinase; MAP Kinase Signaling System - genetics; MAPK/ERK; Mutation; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Oncology; p53 Protein; Pediatrics; Revisions; Signal transduction; Telomerase; TERT; Therapeutic applications; Tumors; Wnt protein; Wnt signaling; Wnt signaling; cancer; MAPK/ERK; TERT; liver

Background Pediatric hepatocellular carcinoma (HCC) is a rare liver tumor in children with a poor prognosis. Comprehensive molecular profiling to understand the underlying genomic drivers of this tumor has not been completed, and it is unclear whether nonfibrolamellar pediatric HCC is more genomical...