Characterization and proteomic profiling of pancreatic cancer‐derived serum exosomes

• Published in: Journal of cellular biochemistry Vol. 120; no. 1; pp. 988 - 999
• Main Authors: Jiao, Yu‐J., Jin, Dan‐D., Jiang, Feng, Liu, Jin‐X., Qu, Li‐S., Ni, Wen‐K., Liu, Zhao‐X., Lu, Cui‐H., Ni, Run‐Z., Zhu, Jing, Xiao, Ming‐B.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2019
• Subjects: Algorithms; Annotations; bioinformatic analysis; Biomarkers, Tumor - metabolism; Calcium-binding protein; Cancer; Cell interactions; Cell Line, Tumor; Cellular communication; Chromatography, Liquid; Cohort Studies; Data processing; Databases, Protein; Encyclopedias; Exosomes; Exosomes - metabolism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomes; Humans; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Microscopy, Electron, Transmission; Pancreatic cancer; pancreatic cancer (PC); Pancreatic Neoplasms - blood; Pancreatic Neoplasms - pathology; Pancreatitis; Patients; Phospholipids; Protein composition; Proteins; Proteome - metabolism; Proteomes; proteomic profiling; serum; Signal Transduction - genetics; Tandem Mass Spectrometry; Transmission electron microscopy; Ultracentrifugation; proteomic profiling; pancreatic cancer (PC); serum; bioinformatic analysis; exosomes

Pancreatic cancer (PC) is one of the most lethal cancers known worldwide, and its prognosis is poor in most patients. Exosomes are nanosized extracellular vesicles, which are released from various cell types. They are involved in cellular communication. The diagnosis and treatment of PC were improve...