Circular RNA in cardiovascular disease

• Published in: Journal of cellular physiology Vol. 234; no. 5; pp. 5588 - 5600
• Main Authors: Altesha, M‐Ashraf, Ni, Tiffany, Khan, Afaan, Liu, Kexiang, Zheng, Xiufen
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2019
• Subjects: Animals; Arteriosclerosis; Atherosclerosis; biogenesis; Biomarkers; Cardiomyopathy; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - genetics; Cardiovascular Diseases - metabolism; Cardiovascular Diseases - pathology; Cardiovascular Diseases - physiopathology; Cardiovascular System - metabolism; Cardiovascular System - pathology; Cardiovascular System - physiopathology; Circular RNA; Congestive heart failure; Coronary artery; Coronary artery disease; Developmental stages; Diagnostic systems; Fibrosis; Gene expression; Gene Expression Regulation; Humans; Hypertrophy; Ischemia; miRNA sponge; Myocardial infarction; Pathogenesis; Reperfusion; Ribonucleic acid; RNA; RNA, Circular - genetics; RNA, Circular - metabolism; Senescence; Signal Transduction; Therapeutic applications; cardiovascular disease; miRNA sponge; biogenesis; circular RNA
• ISSN: 0021-9541; 1097-4652; 1097-4652
• DOI: 10.1002/jcp.27384

Circular RNA (circRNA) are endogenous transcripts that display differential expression across species, developmental stages, and pathologies. Their lack of free ends confers increased stability when compared with linear transcripts, making them ideal candidates for future diagnostic biomarkers and therapeutic interventions. Increasing evidence has implicated circRNA in the pathogenesis of multiple cardiovascular diseases. In this paper, we summarize current understanding of circRNA biogenesis, properties, expression profiles, detection methods, functions, and their implication in cardiac pathologies including/ischemia reperfusion injury, myocardial infarction, cardiac senescence, cardiac fibrosis, cardiomyopathy, cardiac hypertrophy and heart failure, atherosclerosis, coronary artery disease, and aneurysm. Increasing evidence has implicated circular RNA (circRNA) in the pathogenesis of multiple cardiovascular diseases.This review provides scientists and clinicians with a brief summary of the ever‐growing world of circRNAs and their role in cardiac diseases specifically.