A Double‐Blind, Randomized, Controlled Trial of Lovastatin in Early‐Stage Parkinson's Disease

• Published in: Movement disorders Vol. 36; no. 5; pp. 1229 - 1237
• Main Authors: Lin, Chin‐Hsien, Chang, Chin‐Hao, Tai, Chun‐Hwei, Cheng, Mei‐Fang, Chen, Yi‐Chieh, Chao, Ying‐Ting, Huang, Tse‐Le, Yen, Ruoh‐Fang, Wu, Ruey‐Meei
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2021; Wiley Subscription Services, Inc
• Subjects: Animal models; Dopamine; Double-blind studies; Lipophilic; Lovastatin; Movement disorders; Neostriatum; Neurodegenerative diseases; Neuroprotection; Parkinson's disease; Placebos; Positron emission tomography; Putamen; Statins; trial; trial; Parkinson's disease; lovastatin

ABSTRACT Background Recent evidence indicates that lipophilic statins have a neuroprotective benefit in animal models of Parkinson's disease (PD). The objective of this study was to evaluate whether lovastatin has the potential to slow motor symptom progression in patients with early‐stage PD....