Dopamine receptor D2 and ankyrin repeat domain containing one in temporomandibular disorder of adolescents
Background Temporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during adolescence. Aim To investigate the association between TMD and genetic polymorphisms in the DRD2 and ANKK1 in a population of Brazilian adole...
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| Published in | International journal of paediatric dentistry Vol. 29; no. 6; pp. 748 - 755 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Blackwell Publishing Ltd
01.11.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Background
Temporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during adolescence.
Aim
To investigate the association between TMD and genetic polymorphisms in the DRD2 and ANKK1 in a population of Brazilian adolescents.
Design
The TMD group included adolescents diagnosed with any of the following TMD subgroups according to the RDC/TMD criteria: myofascial pain, arthralgia and disc displacement and painful TMD. Genomic DNA for molecular analysis was extracted from buccal cells, and genetic polymorphism rs6275 in DRD2 and rs1800497 in ANKK1 were genotyped by real‐time polymerase chain reactions using the TaqMan assay. Data were analysed using the Epi Info 3.5.7 and Stata software, with significance level of 0.05.
Results
Two hundred fifty‐one individuals were included in this study, 148 subjects presented TMD. For disc displacement, the genetic polymorphisms rs6275 was associated in a recessive model (P = 0.04), whereas the rs6276 and rs1800497 presented only a borderline association in a recessive and dominant models, respectively (P = 0.07 and P = 0.06).
Conclusion
The genetic polymorphism rs6275 in DRD2 was associated with disc displacement in Brazilian adolescents. |
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| AbstractList | BackgroundTemporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during adolescence.AimTo investigate the association between TMD and genetic polymorphisms in the DRD2 and ANKK1 in a population of Brazilian adolescents.DesignThe TMD group included adolescents diagnosed with any of the following TMD subgroups according to the RDC/TMD criteria: myofascial pain, arthralgia and disc displacement and painful TMD. Genomic DNA for molecular analysis was extracted from buccal cells, and genetic polymorphism rs6275 in DRD2 and rs1800497 in ANKK1 were genotyped by real‐time polymerase chain reactions using the TaqMan assay. Data were analysed using the Epi Info 3.5.7 and Stata software, with significance level of 0.05.ResultsTwo hundred fifty‐one individuals were included in this study, 148 subjects presented TMD. For disc displacement, the genetic polymorphisms rs6275 was associated in a recessive model (P = 0.04), whereas the rs6276 and rs1800497 presented only a borderline association in a recessive and dominant models, respectively (P = 0.07 and P = 0.06).ConclusionThe genetic polymorphism rs6275 in DRD2 was associated with disc displacement in Brazilian adolescents. Temporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during adolescence.BACKGROUNDTemporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during adolescence.To investigate the association between TMD and genetic polymorphisms in the DRD2 and ANKK1 in a population of Brazilian adolescents.AIMTo investigate the association between TMD and genetic polymorphisms in the DRD2 and ANKK1 in a population of Brazilian adolescents.The TMD group included adolescents diagnosed with any of the following TMD subgroups according to the RDC/TMD criteria: myofascial pain, arthralgia and disc displacement and painful TMD. Genomic DNA for molecular analysis was extracted from buccal cells, and genetic polymorphism rs6275 in DRD2 and rs1800497 in ANKK1 were genotyped by real-time polymerase chain reactions using the TaqMan assay. Data were analysed using the Epi Info 3.5.7 and Stata software, with significance level of 0.05.DESIGNThe TMD group included adolescents diagnosed with any of the following TMD subgroups according to the RDC/TMD criteria: myofascial pain, arthralgia and disc displacement and painful TMD. Genomic DNA for molecular analysis was extracted from buccal cells, and genetic polymorphism rs6275 in DRD2 and rs1800497 in ANKK1 were genotyped by real-time polymerase chain reactions using the TaqMan assay. Data were analysed using the Epi Info 3.5.7 and Stata software, with significance level of 0.05.Two hundred fifty-one individuals were included in this study, 148 subjects presented TMD. For disc displacement, the genetic polymorphisms rs6275 was associated in a recessive model (P = 0.04), whereas the rs6276 and rs1800497 presented only a borderline association in a recessive and dominant models, respectively (P = 0.07 and P = 0.06).RESULTSTwo hundred fifty-one individuals were included in this study, 148 subjects presented TMD. For disc displacement, the genetic polymorphisms rs6275 was associated in a recessive model (P = 0.04), whereas the rs6276 and rs1800497 presented only a borderline association in a recessive and dominant models, respectively (P = 0.07 and P = 0.06).The genetic polymorphism rs6275 in DRD2 was associated with disc displacement in Brazilian adolescents.CONCLUSIONThe genetic polymorphism rs6275 in DRD2 was associated with disc displacement in Brazilian adolescents. Temporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during adolescence. To investigate the association between TMD and genetic polymorphisms in the DRD2 and ANKK1 in a population of Brazilian adolescents. The TMD group included adolescents diagnosed with any of the following TMD subgroups according to the RDC/TMD criteria: myofascial pain, arthralgia and disc displacement and painful TMD. Genomic DNA for molecular analysis was extracted from buccal cells, and genetic polymorphism rs6275 in DRD2 and rs1800497 in ANKK1 were genotyped by real-time polymerase chain reactions using the TaqMan assay. Data were analysed using the Epi Info 3.5.7 and Stata software, with significance level of 0.05. Two hundred fifty-one individuals were included in this study, 148 subjects presented TMD. For disc displacement, the genetic polymorphisms rs6275 was associated in a recessive model (P = 0.04), whereas the rs6276 and rs1800497 presented only a borderline association in a recessive and dominant models, respectively (P = 0.07 and P = 0.06). The genetic polymorphism rs6275 in DRD2 was associated with disc displacement in Brazilian adolescents. Background Temporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during adolescence. Aim To investigate the association between TMD and genetic polymorphisms in the DRD2 and ANKK1 in a population of Brazilian adolescents. Design The TMD group included adolescents diagnosed with any of the following TMD subgroups according to the RDC/TMD criteria: myofascial pain, arthralgia and disc displacement and painful TMD. Genomic DNA for molecular analysis was extracted from buccal cells, and genetic polymorphism rs6275 in DRD2 and rs1800497 in ANKK1 were genotyped by real‐time polymerase chain reactions using the TaqMan assay. Data were analysed using the Epi Info 3.5.7 and Stata software, with significance level of 0.05. Results Two hundred fifty‐one individuals were included in this study, 148 subjects presented TMD. For disc displacement, the genetic polymorphisms rs6275 was associated in a recessive model (P = 0.04), whereas the rs6276 and rs1800497 presented only a borderline association in a recessive and dominant models, respectively (P = 0.07 and P = 0.06). Conclusion The genetic polymorphism rs6275 in DRD2 was associated with disc displacement in Brazilian adolescents. |
| Author | Souza, Juliana Feltrin Meger, Michelle Nascimento Scariot, Rafaela Küchler, Erika Calvano Wambier, Letícia Maira Brancher, João Armando Faturri, Aluhe Lopes Franco, Gizele Batista Paiva Bertoli, Fernanda Mara |
| Author_xml | – sequence: 1 givenname: Gizele Batista surname: Franco fullname: Franco, Gizele Batista organization: Universidade Positivo – sequence: 2 givenname: Aluhe Lopes surname: Faturri fullname: Faturri, Aluhe Lopes organization: Universidade Federal do Paraná – sequence: 3 givenname: Michelle Nascimento surname: Meger fullname: Meger, Michelle Nascimento organization: Universidade Positivo – sequence: 4 givenname: Fernanda Mara surname: Paiva Bertoli fullname: Paiva Bertoli, Fernanda Mara organization: Universidade Positivo – sequence: 5 givenname: Letícia Maira surname: Wambier fullname: Wambier, Letícia Maira organization: Universidade Positivo – sequence: 6 givenname: Rafaela surname: Scariot fullname: Scariot, Rafaela organization: Universidade Positivo – sequence: 7 givenname: Juliana Feltrin surname: Souza fullname: Souza, Juliana Feltrin organization: Universidade Federal do Paraná – sequence: 8 givenname: Erika Calvano orcidid: 0000-0001-5351-2526 surname: Küchler fullname: Küchler, Erika Calvano organization: Universidade Positivo – sequence: 9 givenname: João Armando orcidid: 0000-0002-8914-702X surname: Brancher fullname: Brancher, João Armando email: brancher.a@gmail.com organization: Universidade Positivo |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31144779$$D View this record in MEDLINE/PubMed |
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Temporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during... Temporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during adolescence.... BackgroundTemporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during... Temporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during... |
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| SubjectTerms | Adolescent Adolescents Ankyrin Repeat Ankyrins Arthralgia Brazil disc displacement Dopamine D2 receptors Gene polymorphism Genetic factors genetic polymorphisms Genotype Humans Mouth Mucosa Polymorphism Teenagers Temporomandibular Joint Disorders TMJ diseases |
| Title | Dopamine receptor D2 and ankyrin repeat domain containing one in temporomandibular disorder of adolescents |
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