Aberrant Super‐Enhancer Landscape in Human Hepatocellular Carcinoma

• Published in: Hepatology (Baltimore, Md.) Vol. 69; no. 6; pp. 2502 - 2517
• Main Authors: Tsang, Felice Ho‐Ching, Law, Cheuk‐Ting, Tang, Tsz‐Ching Chloe, Cheng, Carol Lai‐Hung, Chin, Don Wai‐Ching, Tam, Wing‐Sum Vincy, Wei, Lai, Wong, Carmen Chak‐Lui, Ng, Irene Oi‐Lin, Wong, Chun‐Ming
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.06.2019
• Subjects: Carcinogenesis; CRISPR; Enhancers; Event-related potentials; Genome editing; Hepatocellular carcinoma; Hepatocytes; Hepatology; Kinases; Liver cancer; Sphingosine kinase; Transcription

Hepatocellular carcinoma (HCC) cells exploit an aberrant transcriptional program to sustain their infinite growth and progression. Emerging evidence indicates that the continuous and robust transcription of oncogenes in cancer cells is often driven by super‐enhancers (SEs). In this study, we systema...