Silencing microRNA‐221/222 cluster suppresses glioblastoma angiogenesis by suppressor of cytokine signaling‐3‐dependent JAK/STAT pathway

• Published in: Journal of cellular physiology Vol. 234; no. 12; pp. 22272 - 22284
• Main Authors: Xu, Chun‐Hua, Liu, Yue, Xiao, Li‐Min, Chen, Li‐Ke, Zheng, Su‐Yue, Zeng, Er‐Ming, Li, Dong‐Hai, Li, You‐Ping
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2019
• Subjects: Angiogenesis; Biological activity; Brain; Brain cancer; Brain tumors; Cell migration; Clusters; Cytokines; Deactivation; DNA microarrays; Glioblastoma; Glioblastoma cells; Glioma; Growth factors; Inactivation; Janus kinase; Janus kinase 2; janus kinase/signal transducers and activators of transcription pathway; Kinases; Matrix metalloproteinase; Matrix metalloproteinases; Metalloproteinase; MicroRNAs; microRNA‐221/222 cluster; miRNA; Proteins; Ribonucleic acid; RNA; Signal transduction; Signaling; Stat3 protein; suppressor of cytokine signaling‐3; Transcription factors; Transducers; Tumorigenesis; Vascular endothelial growth factor; janus kinase/signal transducers and activators of transcription pathway; suppressor of cytokine signaling-3; glioblastoma; angiogenesis; microRNA-221/222 cluster

Angiogenesis is a major pathologic characteristic of glioblastoma, which is one aggressive primary brain tumor. MicroRNA‐221/222 (miR‐221/222) cluster has been previously reported to function importantly in malignant glioma biological process. The current study aims at evaluating the effects of miR‐...