Acetoacetate induces hepatocytes apoptosis by the ROS‐mediated MAPKs pathway in ketotic cows

• Published in: Journal of cellular physiology Vol. 232; no. 12; pp. 3296 - 3308
• Main Authors: Du, Xiliang, Shi, Zhen, Peng, Zhicheng, Zhao, Chenxu, Zhang, Yuming, Wang, Zhe, Li, Xiaobing, Liu, Guowen, Li, Xinwei
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2017
• Subjects: acetoacetate; Acetoacetates - pharmacology; Acetylcysteine; Animals; Apoptosis; Apoptosis - drug effects; Bcl-2 protein; Caspase; Caspase-3; Caspase-9; Cattle; Cells, Cultured; Dairy cattle; Damage; Deoxyribonucleic acid; DNA; Female; Gene expression; Hepatocytes; Hepatocytes - cytology; Hepatocytes - drug effects; Hepatocytes - metabolism; In vitro methods and tests; JNK protein; Ketones; Ketosis; ketotic cows; Liver; Localization; MAP Kinase Signaling System; mitogen‐activated protein kinases; Oxidative Stress; p53 Protein; Phosphorylation; Poly(ADP-ribose) polymerase; Reactive oxygen species; Reactive Oxygen Species - metabolism; apoptosis; ketotic cows; acetoacetate; mitogen-activated protein kinases; reactive oxygen species

Dairy cows with ketosis are characterized by oxidative stress, hepatic damage, and hyperketonemia. Acetoacetate (AA) is the main component of ketone bodies in ketotic cows, and is associated with the above pathological process. However, the potential mechanism was not illuminated. Therefore, the aim...