Acetoacetate induces hepatocytes apoptosis by the ROS‐mediated MAPKs pathway in ketotic cows - Du, Xiliang; Shi, Zhen; Peng, Zhicheng; Zhao, Chenxu; Zhang, Yuming; Wang, Zhe; Li, Xiaobing; Liu, Guowen; Li, Xinwei (Journal of cellular physiology, 2017)
Keywords: acetoacetate; Acetoacetates - pharmacology; Acetylcysteine; Animals; Apoptosis; Apoptosis - drug effects; Bcl-2 protein; Caspase; Caspase-3; Caspase-9; Cattle; Cells, Cultured; Dairy cattle; Damage; Deoxyribonucleic acid; DNA; Female; Gene expression; Hepatocytes; Hepatocytes - cytology; Hepatocytes - drug effects; Hepatocytes - metabolism; In vitro methods and tests; JNK protein; Ketones; Ketosis; ketotic cows; Liver; Localization; MAP Kinase Signaling System; mitogen‐activated protein kinases; Oxidative Stress; p53 Protein; Phosphorylation; Poly(ADP-ribose) polymerase; Reactive oxygen species; Reactive Oxygen Species - metabolism; apoptosis; ketotic cows; acetoacetate; mitogen-activated protein kinases; reactive oxygen species