Usefulness of saliva for perampanel therapeutic drug monitoring

• Published in: Epilepsia (Copenhagen) Vol. 61; no. 6; pp. 1120 - 1128
• Main Authors: Kim, Do‐Yong, Moon, Jangsup, Shin, Yong‐Won, Lee, Soon‐Tae, Jung, Keun‐Hwa, Park, Kyung‐Il, Jung, Ki‐Young, Kim, Manho, Lee, SeungHwan, Yu, Kyung‐Sang, Jang, In‐Jin, Song, KaHeon, Chu, Kon, Lee, Sangkun
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2020
• Subjects: Antiepileptic agents; correlation; Cytochrome P450; Epilepsy; High-performance liquid chromatography; Mass spectroscopy; Patients; perampanel; Plasma; Saliva; therapeutic drug monitoring; perampanel; saliva; correlation; plasma; therapeutic drug monitoring

Objective Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) helps optimize drug management for patients with epilepsy. Salivary testing is both noninvasive and easy, and has several other advantages. Due to technical advances, salivary TDM has become feasible for several drugs, includi...