RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2

• Published in: Hepatology (Baltimore, Md.) Vol. 67; no. 6; pp. 2254 - 2270
• Main Authors: Chen, Mengnuo, Wei, Lai, Law, Cheuk‐Ting, Tsang, Felice Ho‐Ching, Shen, Jialing, Cheng, Carol Lai‐Hung, Tsang, Long‐Hin, Ho, Daniel Wai‐Hung, Chiu, David Kung‐Chun, Lee, Joyce Man‐Fong, Wong, Carmen Chak‐Lui, Ng, Irene Oi‐Lin, Wong, Chun‐Ming
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.06.2018
• Subjects: Adenosine; Animals; Carcinogenesis; Carcinoma, Hepatocellular - enzymology; Carcinoma, Hepatocellular - etiology; Cell migration; Cell proliferation; Chemical modification; Chromatin remodeling; CRISPR; Disease Progression; DNA methylation; Epigenetics; Gene expression; Hepatocellular carcinoma; Hepatology; Humans; Liver cancer; Liver Neoplasms - enzymology; Liver Neoplasms - etiology; Metastases; Methyltransferases - physiology; Mice; mRNA stability; N6-methyladenosine; Polymerase chain reaction; Post-transcription; RNA Interference; RNA modification; RNA-Binding Proteins - physiology; Solid tumors; Splicing; Suppressor of Cytokine Signaling Proteins - genetics; Tumorigenicity

Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling. Recently, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epig...