RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2
Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling. Recently, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epig...
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| Published in | Hepatology (Baltimore, Md.) Vol. 67; no. 6; pp. 2254 - 2270 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wolters Kluwer Health, Inc
01.06.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling. Recently, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epigenetic regulation. N6‐methyladenosine (m6A) is the most abundant chemical modification of eukaryotic messenger RNA (mRNA) and is important for the regulation of mRNA stability, splicing, and translation. Using transcriptome sequencing, we discovered that methyltransferase‐like 3 (METTL3), a major RNA N6‐adenosine methyltransferase, was significantly up‐regulated in human hepatocellular carcinoma (HCC) and multiple solid tumors. Clinically, overexpression of METTL3 is associated with poor prognosis of patients with HCC. Functionally, we proved that knockdown of METTL3 drastically reduced HCC cell proliferation, migration, and colony formation in vitro. Knockout of METTL3 remarkably suppressed HCC tumorigenicity and lung metastasis in vivo. On the other hand, using the CRISPR/dCas9‐VP64 activation system, we demonstrated that overexpression of METTL3 significantly promoted HCC growth both in vitro and in vivo. Through transcriptome sequencing, m6A sequencing, and m6A methylated RNA immuno‐precipitation quantitative reverse‐transcription polymerase chain reaction, we identified suppressor of cytokine signaling 2 (SOCS2) as a target of METTL3‐mediated m6A modification. Knockdown of METTL3 substantially abolished SOCS2 mRNA m6A modification and augmented SOCS2 mRNA expression. We also showed that m6A‐mediated SOCS2 mRNA degradation relied on the m6A reader protein YTHDF2‐dependent pathway. Conclusion: METTL3 is frequently up‐regulated in human HCC and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A‐YTHDF2‐dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis. (Hepatology 2018;67:2254‐2270). |
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| AbstractList | Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling. Recently, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epigenetic regulation. N6‐methyladenosine (m6A) is the most abundant chemical modification of eukaryotic messenger RNA (mRNA) and is important for the regulation of mRNA stability, splicing, and translation. Using transcriptome sequencing, we discovered that methyltransferase‐like 3 (METTL3), a major RNA N6‐adenosine methyltransferase, was significantly up‐regulated in human hepatocellular carcinoma (HCC) and multiple solid tumors. Clinically, overexpression of METTL3 is associated with poor prognosis of patients with HCC. Functionally, we proved that knockdown of METTL3 drastically reduced HCC cell proliferation, migration, and colony formation in vitro. Knockout of METTL3 remarkably suppressed HCC tumorigenicity and lung metastasis in vivo. On the other hand, using the CRISPR/dCas9‐VP64 activation system, we demonstrated that overexpression of METTL3 significantly promoted HCC growth both in vitro and in vivo. Through transcriptome sequencing, m6A sequencing, and m6A methylated RNA immuno‐precipitation quantitative reverse‐transcription polymerase chain reaction, we identified suppressor of cytokine signaling 2 (SOCS2) as a target of METTL3‐mediated m6A modification. Knockdown of METTL3 substantially abolished SOCS2 mRNA m6A modification and augmented SOCS2 mRNA expression. We also showed that m6A‐mediated SOCS2 mRNA degradation relied on the m6A reader protein YTHDF2‐dependent pathway. Conclusion: METTL3 is frequently up‐regulated in human HCC and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A‐YTHDF2‐dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis. (Hepatology 2018;67:2254‐2270). Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling. Recently, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epigenetic regulation. N6‐methyladenosine (m6A) is the most abundant chemical modification of eukaryotic messenger RNA (mRNA) and is important for the regulation of mRNA stability, splicing, and translation. Using transcriptome sequencing, we discovered that methyltransferase‐like 3 (METTL3), a major RNA N6‐adenosine methyltransferase, was significantly up‐regulated in human hepatocellular carcinoma (HCC) and multiple solid tumors. Clinically, overexpression of METTL3 is associated with poor prognosis of patients with HCC. Functionally, we proved that knockdown of METTL3 drastically reduced HCC cell proliferation, migration, and colony formation in vitro . Knockout of METTL3 remarkably suppressed HCC tumorigenicity and lung metastasis in vivo . On the other hand, using the CRISPR/dCas9‐VP64 activation system, we demonstrated that overexpression of METTL3 significantly promoted HCC growth both in vitro and in vivo . Through transcriptome sequencing, m6A sequencing, and m6A methylated RNA immuno‐precipitation quantitative reverse‐transcription polymerase chain reaction, we identified suppressor of cytokine signaling 2 (SOCS2) as a target of METTL3‐mediated m6A modification. Knockdown of METTL3 substantially abolished SOCS2 mRNA m6A modification and augmented SOCS2 mRNA expression. We also showed that m6A‐mediated SOCS2 mRNA degradation relied on the m6A reader protein YTHDF2‐dependent pathway. Conclusion : METTL3 is frequently up‐regulated in human HCC and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A‐YTHDF2‐dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis. (H epatology 2018;67:2254‐2270). Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling. Recently, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epigenetic regulation. N6-methyladenosine (m6A) is the most abundant chemical modification of eukaryotic messenger RNA (mRNA) and is important for the regulation of mRNA stability, splicing, and translation. Using transcriptome sequencing, we discovered that methyltransferase-like 3 (METTL3), a major RNA N6-adenosine methyltransferase, was significantly up-regulated in human hepatocellular carcinoma (HCC) and multiple solid tumors. Clinically, overexpression of METTL3 is associated with poor prognosis of patients with HCC. Functionally, we proved that knockdown of METTL3 drastically reduced HCC cell proliferation, migration, and colony formation in vitro. Knockout of METTL3 remarkably suppressed HCC tumorigenicity and lung metastasis in vivo. On the other hand, using the CRISPR/dCas9-VP64 activation system, we demonstrated that overexpression of METTL3 significantly promoted HCC growth both in vitro and in vivo. Through transcriptome sequencing, m6A sequencing, and m6A methylated RNA immuno-precipitation quantitative reverse-transcription polymerase chain reaction, we identified suppressor of cytokine signaling 2 (SOCS2) as a target of METTL3-mediated m6A modification. Knockdown of METTL3 substantially abolished SOCS2 mRNA m6A modification and augmented SOCS2 mRNA expression. We also showed that m6A-mediated SOCS2 mRNA degradation relied on the m6A reader protein YTHDF2-dependent pathway. METTL3 is frequently up-regulated in human HCC and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A-YTHDF2-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis. (Hepatology 2018;67:2254-2270). Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling. Recently, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epigenetic regulation. N6-methyladenosine (m6A) is the most abundant chemical modification of eukaryotic messenger RNA (mRNA) and is important for the regulation of mRNA stability, splicing, and translation. Using transcriptome sequencing, we discovered that methyltransferase-like 3 (METTL3), a major RNA N6-adenosine methyltransferase, was significantly up-regulated in human hepatocellular carcinoma (HCC) and multiple solid tumors. Clinically, overexpression of METTL3 is associated with poor prognosis of patients with HCC. Functionally, we proved that knockdown of METTL3 drastically reduced HCC cell proliferation, migration, and colony formation in vitro. Knockout of METTL3 remarkably suppressed HCC tumorigenicity and lung metastasis in vivo. On the other hand, using the CRISPR/dCas9-VP64 activation system, we demonstrated that overexpression of METTL3 significantly promoted HCC growth both in vitro and in vivo. Through transcriptome sequencing, m6A sequencing, and m6A methylated RNA immuno-precipitation quantitative reverse-transcription polymerase chain reaction, we identified suppressor of cytokine signaling 2 (SOCS2) as a target of METTL3-mediated m6A modification. Knockdown of METTL3 substantially abolished SOCS2 mRNA m6A modification and augmented SOCS2 mRNA expression. We also showed that m6A-mediated SOCS2 mRNA degradation relied on the m6A reader protein YTHDF2-dependent pathway.Epigenetic alterations have contributed greatly to human carcinogenesis. Conventional epigenetic studies have predominantly focused on DNA methylation, histone modifications, and chromatin remodeling. Recently, diverse and reversible chemical modifications of RNAs have emerged as a new layer of epigenetic regulation. N6-methyladenosine (m6A) is the most abundant chemical modification of eukaryotic messenger RNA (mRNA) and is important for the regulation of mRNA stability, splicing, and translation. Using transcriptome sequencing, we discovered that methyltransferase-like 3 (METTL3), a major RNA N6-adenosine methyltransferase, was significantly up-regulated in human hepatocellular carcinoma (HCC) and multiple solid tumors. Clinically, overexpression of METTL3 is associated with poor prognosis of patients with HCC. Functionally, we proved that knockdown of METTL3 drastically reduced HCC cell proliferation, migration, and colony formation in vitro. Knockout of METTL3 remarkably suppressed HCC tumorigenicity and lung metastasis in vivo. On the other hand, using the CRISPR/dCas9-VP64 activation system, we demonstrated that overexpression of METTL3 significantly promoted HCC growth both in vitro and in vivo. Through transcriptome sequencing, m6A sequencing, and m6A methylated RNA immuno-precipitation quantitative reverse-transcription polymerase chain reaction, we identified suppressor of cytokine signaling 2 (SOCS2) as a target of METTL3-mediated m6A modification. Knockdown of METTL3 substantially abolished SOCS2 mRNA m6A modification and augmented SOCS2 mRNA expression. We also showed that m6A-mediated SOCS2 mRNA degradation relied on the m6A reader protein YTHDF2-dependent pathway.METTL3 is frequently up-regulated in human HCC and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A-YTHDF2-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis. (Hepatology 2018;67:2254-2270).CONCLUSIONMETTL3 is frequently up-regulated in human HCC and contributes to HCC progression. METTL3 represses SOCS2 expression in HCC through an m6A-YTHDF2-dependent mechanism. Our findings suggest an important mechanism of epigenetic alteration in liver carcinogenesis. (Hepatology 2018;67:2254-2270). |
| Author | Ho, Daniel Wai‐Hung Lee, Joyce Man‐Fong Wei, Lai Tsang, Felice Ho‐Ching Cheng, Carol Lai‐Hung Wong, Carmen Chak‐Lui Wong, Chun‐Ming Tsang, Long‐Hin Law, Cheuk‐Ting Chiu, David Kung‐Chun Chen, Mengnuo Ng, Irene Oi‐Lin Shen, Jialing |
| Author_xml | – sequence: 1 givenname: Mengnuo surname: Chen fullname: Chen, Mengnuo organization: University of Hong Kong – sequence: 2 givenname: Lai surname: Wei fullname: Wei, Lai organization: University of Hong Kong – sequence: 3 givenname: Cheuk‐Ting surname: Law fullname: Law, Cheuk‐Ting organization: University of Hong Kong – sequence: 4 givenname: Felice Ho‐Ching surname: Tsang fullname: Tsang, Felice Ho‐Ching organization: University of Hong Kong – sequence: 5 givenname: Jialing surname: Shen fullname: Shen, Jialing organization: University of Hong Kong – sequence: 6 givenname: Carol Lai‐Hung surname: Cheng fullname: Cheng, Carol Lai‐Hung organization: University of Hong Kong – sequence: 7 givenname: Long‐Hin surname: Tsang fullname: Tsang, Long‐Hin organization: University of Hong Kong – sequence: 8 givenname: Daniel Wai‐Hung surname: Ho fullname: Ho, Daniel Wai‐Hung organization: University of Hong Kong – sequence: 9 givenname: David Kung‐Chun surname: Chiu fullname: Chiu, David Kung‐Chun organization: University of Hong Kong – sequence: 10 givenname: Joyce Man‐Fong surname: Lee fullname: Lee, Joyce Man‐Fong organization: University of Hong Kong – sequence: 11 givenname: Carmen Chak‐Lui surname: Wong fullname: Wong, Carmen Chak‐Lui organization: University of Hong Kong – sequence: 12 givenname: Irene Oi‐Lin surname: Ng fullname: Ng, Irene Oi‐Lin email: iolng@hku.hk organization: University of Hong Kong – sequence: 13 givenname: Chun‐Ming orcidid: 0000-0002-2497-7858 surname: Wong fullname: Wong, Chun‐Ming email: jackwong@pathology.hku.hk organization: University of Hong Kong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29171881$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.cell.2015.05.014 10.1038/nature15377 10.1016/j.celrep.2017.02.059 10.1016/j.jhep.2017.05.015 10.1016/j.cell.2012.05.003 10.1016/j.ccell.2016.11.017 10.1002/hep.28304 10.1038/nature12730 10.1038/nchembio.1432 10.1038/nrm.2016.132 10.1016/j.celrep.2014.05.048 10.1038/nature14136 10.1016/j.cell.2013.10.028 10.1038/nmeth.3047 10.1016/j.stem.2014.09.019 10.1093/nar/gkf573 10.1016/0304-3835(96)04203-6 10.1016/j.stem.2015.01.016 10.1038/nature11112 10.1038/ncb2902 10.1016/j.molcel.2016.03.021 10.1038/ng.3252 10.1038/ng0501-29 10.1007/s13277-016-5215-7 10.1126/science.1261417 10.1038/nrg3724 10.1038/cr.2014.3 10.1002/hep.27732 10.1038/nprot.2012.148 10.1038/nature14281 10.1038/nchembio.687 10.1002/hep.21578 10.1002/hep.25679 10.1093/nar/gku1024 10.1002/hep.26083 10.1016/j.molcel.2012.10.015 10.1016/j.cell.2015.10.012 10.1055/s-2007-1007117 10.1002/hep.28885 |
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| Notes | Potential conflict of interest: Nothing to report. Supported by the Hong Kong Research Grants Council (RGC) General Research Fund (17142516 and 17115815) to C.M.W., RGC Theme‐Based Research Scheme (T12‐704/16R) to I.N., National Natural Science Foundation of China General Program (81572446) to C.M.W., and the University of Hong Kong Seed Funding Program for Basic Research (201511159077) to C.M.W. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
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| PublicationDate | June 2018 |
| PublicationDateYYYYMMDD | 2018-06-01 |
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| PublicationTitle | Hepatology (Baltimore, Md.) |
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| Publisher | Wolters Kluwer Health, Inc |
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| References | 2015; 163 2015; 161 2012; 485 2015; 16 2013; 49 2015; 347 2002; 30 2017; 65 2017; 67 2014; 24 2015; 526 2001; 28 1996; 103 2013; 8 2012; 56 2012; 149 2016; 37 2011; 7 2017; 31 2015; 47 2014; 505 1999; 19 2013; 57 2015; 61 2015; 43 2014; 16 2016; 113 2014; 15 2013; 155 2015; 519 2016; 63 2016; 62 2015; 517 2017; 18 2014; 8 2003; 63 2007; 45 2014; 11 2014; 10 (hep29683-bib-0007-20241017) 2016; 63 (hep29683-bib-0025-20241017) 2002; 30 (hep29683-bib-0005-20241017) 2003; 63 (hep29683-bib-0016-20241017) 2014; 8 (hep29683-bib-0009-20241017) 2013; 57 (hep29683-bib-0017-20241017) 2011; 7 (hep29683-bib-0031-20241017) 2016; 62 (hep29683-bib-0015-20241017) 2014; 24 (hep29683-bib-0035-20241017) 2015; 43 (hep29683-bib-0012-20241017) 2012; 485 (hep29683-bib-0034-20241017) 2013; 8 (hep29683-bib-0003-20241017) 2014; 15 (hep29683-bib-0033-20241017) 2015; 517 (hep29683-bib-0021-20241017) 2013; 155 (hep29683-bib-0026-20241017) 2016; 113 (hep29683-bib-0014-20241017) 2014; 10 (hep29683-bib-0041-20241017) 2016; 37 (hep29683-bib-0001-20241017) 1999; 19 (hep29683-bib-0011-20241017) 2017; 18 (hep29683-bib-0028-20241017) 1996; 103 (hep29683-bib-0032-20241017) 2014; 11 (hep29683-bib-0024-20241017) 2015; 347 (hep29683-bib-0029-20241017) 2017; 31 (hep29683-bib-0036-20241017) 2001; 28 (hep29683-bib-0013-20241017) 2012; 149 (hep29683-bib-0022-20241017) 2014; 16 (hep29683-bib-0023-20241017) 2014; 15 (hep29683-bib-0039-20241017) 2015; 16 (hep29683-bib-0030-20241017) 2015; 526 (hep29683-bib-0040-20241017) 2015; 161 (hep29683-bib-0037-20241017) 2015; 519 (hep29683-bib-0038-20241017) 2017; 65 (hep29683-bib-0006-20241017) 2007; 45 (hep29683-bib-0027-20241017) 2017; 18 (hep29683-bib-0004-20241017) 2015; 61 (hep29683-bib-0010-20241017) 2017; 67 (hep29683-bib-0008-20241017) 2012; 56 (hep29683-bib-0018-20241017) 2013; 49 (hep29683-bib-0020-20241017) 2015; 163 (hep29683-bib-0002-20241017) 2015; 47 (hep29683-bib-0019-20241017) 2014; 505 |
| References_xml | – volume: 19 start-page: 271 year: 1999 end-page: 285 article-title: Epidemiology of primary liver cancer publication-title: Semin Liver Dis – volume: 485 start-page: 201 year: 2012 end-page: 206 article-title: Topology of the human and mouse m6A RNA methylomes revealed by m6A‐seq publication-title: Nature – volume: 57 start-page: 637 year: 2013 end-page: 647 article-title: Histone lysine methyltransferase, suppressor of variegation 3‐9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA‐125b publication-title: Hepatology – volume: 526 start-page: 591 year: 2015 end-page: 594 article-title: Dynamic m(6)A mRNA methylation directs translational control of heat shock response publication-title: Nature – volume: 7 start-page: 885 year: 2011 end-page: 887 article-title: N6‐methyladenosine in nuclear RNA is a major substrate of the obesity‐associated FTO publication-title: Nat Chem Biol – volume: 505 start-page: 117 year: 2014 end-page: 120 article-title: N6‐methyladenosine‐dependent regulation of messenger RNA stability publication-title: Nature – volume: 103 start-page: 107 year: 1996 end-page: 113 article-title: Elevation of internal 6‐methyladenine mRNA methyltransferase activity after cellular transformation publication-title: Cancer Lett – volume: 519 start-page: 482 year: 2015 end-page: 485 article-title: N‐6‐methyladenosine marks primary microRNAs for processing publication-title: Nature – volume: 24 start-page: 177 year: 2014 end-page: 189 article-title: Mammalian WTAP is a regulatory subunit of the RNA N6‐methyladenosine methyltransferase publication-title: Cell Res – volume: 18 start-page: 2622 year: 2017 end-page: 2634 article-title: m6A RNA methylation regulates the self‐renewal and tumorigenesis of glioblastoma stem cells publication-title: Cell Rep – volume: 45 start-page: 1129 year: 2007 end-page: 1138 article-title: Tissue factor pathway inhibitor‐2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma publication-title: Hepatology – volume: 49 start-page: 18 year: 2013 end-page: 29 article-title: ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility publication-title: Mol Cell – volume: 347 start-page: 1002 year: 2015 end-page: 1006 article-title: Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation publication-title: Science – volume: 16 start-page: 191 year: 2014 end-page: 198 article-title: N6‐methyladenosine modification destabilizes developmental regulators in embryonic stem cells publication-title: Nat Cell Biol – volume: 11 start-page: 783 year: 2014 end-page: 784 article-title: Improved vectors and genome‐wide libraries for CRISPR screening publication-title: Nat Methods – volume: 10 start-page: 93 year: 2014 end-page: 95 article-title: A METTL3‐METTL14 complex mediates mammalian nuclear RNA N6‐adenosine methylation publication-title: Nat Chem Biol – volume: 61 start-page: 1945 year: 2015 end-page: 1956 article-title: DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma publication-title: Hepatology – volume: 63 start-page: 474 year: 2016 end-page: 487 article-title: Up‐regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis publication-title: Hepatology – volume: 113 start-page: E2047 year: 2016 end-page: E2056 article-title: Hypoxia induces the breast cancer stem cell phenotype by HIF‐dependent and ALKBH5‐mediated m(6)A‐demethylation of NANOG mRNA publication-title: Proc Natl Acad Sci U S A – volume: 163 start-page: 999 year: 2015 end-page: 1010 article-title: 5′ UTR m(6)A promotes cap‐independent translation publication-title: Cell – volume: 517 start-page: 583 year: 2015 end-page: 588 article-title: Genome‐scale transcriptional activation by an engineered CRISPR‐Cas9 complex publication-title: Nature – volume: 16 start-page: 289 year: 2015 end-page: 301 article-title: m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency publication-title: Cell Stem Cell – volume: 8 start-page: 284 year: 2014 end-page: 296 article-title: Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites publication-title: Cell Rep – volume: 30 start-page: 4509 year: 2002 end-page: 4518 article-title: Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6‐methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene publication-title: Nucleic Acids Res – volume: 67 start-page: 758 year: 2017 end-page: 769 article-title: Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3 publication-title: J Hepatol – volume: 8 start-page: 176 year: 2013 end-page: 189 article-title: Transcriptome‐wide mapping of N(6)‐methyladenosine by m(6)A‐seq based on immunocapturing and massively parallel sequencing publication-title: Nat Protoc – volume: 31 start-page: 127 year: 2017 end-page: 141 article-title: FTO plays an oncogenic role in acute myeloid leukemia as a N6‐methyladenosine RNA demethylase publication-title: Cancer Cell – volume: 149 start-page: 1635 year: 2012 end-page: 1646 article-title: Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons publication-title: Cell – volume: 62 start-page: 335 year: 2016 end-page: 345 article-title: The m(6)A methyltransferase METTL3 promotes translation in human cancer cells publication-title: Mol Cell – volume: 37 start-page: 13521 year: 2016 end-page: 13531 article-title: The suppressor of cytokine signaling 2 (SOCS2) inhibits tumor metastasis in hepatocellular carcinoma publication-title: Tumour Biol – volume: 28 start-page: 29 year: 2001 end-page: 35 article-title: SOCS‐1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth‐suppression activity publication-title: Nat Genet – volume: 18 start-page: 31 year: 2017 end-page: 42 article-title: Post‐transcriptional gene regulation by mRNA modifications publication-title: Nat Rev Mol Cell Biol – volume: 56 start-page: 622 year: 2012 end-page: 631 article-title: Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis publication-title: Hepatology – volume: 65 start-page: 529 year: 2017 end-page: 543 article-title: METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6‐methyladenosine‐dependent primary MicroRNA processing publication-title: Hepatology – volume: 15 start-page: 707 year: 2014 end-page: 719 article-title: m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells publication-title: Cell Stem Cell – volume: 15 start-page: 293 year: 2014 end-page: 306 article-title: Gene expression regulation mediated through reversible m(6)A RNA methylation publication-title: Nat Rev Genet – volume: 63 start-page: 7646 year: 2003 end-page: 7651 article-title: Genetic and epigenetic alterations of DLC‐1 gene in hepatocellular carcinoma publication-title: Cancer Res – volume: 47 start-page: 505 year: 2015 end-page: 511 article-title: Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets publication-title: Nat Genet – volume: 155 start-page: 740 year: 2013 end-page: 741 article-title: m(6)A mRNA methylation: a new circadian pacesetter publication-title: Cell – volume: 43 start-page: D197 year: 2015 end-page: D203 article-title: MeT‐DB: a database of transcriptome methylation in mammalian cells publication-title: Nucleic Acids Res – volume: 161 start-page: 1388 year: 2015 end-page: 1399 article-title: N(6)‐methyladenosine modulates messenger RNA translation efficiency publication-title: Cell – volume: 161 start-page: 1388 year: 2015 ident: hep29683-bib-0040-20241017 article-title: N(6)‐methyladenosine modulates messenger RNA translation efficiency publication-title: Cell doi: 10.1016/j.cell.2015.05.014 – volume: 526 start-page: 591 year: 2015 ident: hep29683-bib-0030-20241017 article-title: Dynamic m(6)A mRNA methylation directs translational control of heat shock response publication-title: Nature doi: 10.1038/nature15377 – volume: 18 start-page: 2622 year: 2017 ident: hep29683-bib-0027-20241017 article-title: m6A RNA methylation regulates the self‐renewal and tumorigenesis of glioblastoma stem cells publication-title: Cell Rep doi: 10.1016/j.celrep.2017.02.059 – volume: 67 start-page: 758 year: 2017 ident: hep29683-bib-0010-20241017 article-title: Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3 publication-title: J Hepatol doi: 10.1016/j.jhep.2017.05.015 – volume: 149 start-page: 1635 year: 2012 ident: hep29683-bib-0013-20241017 article-title: Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons publication-title: Cell doi: 10.1016/j.cell.2012.05.003 – volume: 31 start-page: 127 year: 2017 ident: hep29683-bib-0029-20241017 article-title: FTO plays an oncogenic role in acute myeloid leukemia as a N6‐methyladenosine RNA demethylase publication-title: Cancer Cell doi: 10.1016/j.ccell.2016.11.017 – volume: 63 start-page: 474 year: 2016 ident: hep29683-bib-0007-20241017 article-title: Up‐regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis publication-title: Hepatology doi: 10.1002/hep.28304 – volume: 505 start-page: 117 year: 2014 ident: hep29683-bib-0019-20241017 article-title: N6‐methyladenosine‐dependent regulation of messenger RNA stability publication-title: Nature doi: 10.1038/nature12730 – volume: 10 start-page: 93 year: 2014 ident: hep29683-bib-0014-20241017 article-title: A METTL3‐METTL14 complex mediates mammalian nuclear RNA N6‐adenosine methylation publication-title: Nat Chem Biol doi: 10.1038/nchembio.1432 – volume: 18 start-page: 31 year: 2017 ident: hep29683-bib-0011-20241017 article-title: Post‐transcriptional gene regulation by mRNA modifications publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm.2016.132 – volume: 8 start-page: 284 year: 2014 ident: hep29683-bib-0016-20241017 article-title: Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites publication-title: Cell Rep doi: 10.1016/j.celrep.2014.05.048 – volume: 517 start-page: 583 year: 2015 ident: hep29683-bib-0033-20241017 article-title: Genome‐scale transcriptional activation by an engineered CRISPR‐Cas9 complex publication-title: Nature doi: 10.1038/nature14136 – volume: 155 start-page: 740 year: 2013 ident: hep29683-bib-0021-20241017 article-title: m(6)A mRNA methylation: a new circadian pacesetter publication-title: Cell doi: 10.1016/j.cell.2013.10.028 – volume: 11 start-page: 783 year: 2014 ident: hep29683-bib-0032-20241017 article-title: Improved vectors and genome‐wide libraries for CRISPR screening publication-title: Nat Methods doi: 10.1038/nmeth.3047 – volume: 15 start-page: 707 year: 2014 ident: hep29683-bib-0023-20241017 article-title: m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2014.09.019 – volume: 30 start-page: 4509 year: 2002 ident: hep29683-bib-0025-20241017 article-title: Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6‐methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene publication-title: Nucleic Acids Res doi: 10.1093/nar/gkf573 – volume: 103 start-page: 107 year: 1996 ident: hep29683-bib-0028-20241017 article-title: Elevation of internal 6‐methyladenine mRNA methyltransferase activity after cellular transformation publication-title: Cancer Lett doi: 10.1016/0304-3835(96)04203-6 – volume: 16 start-page: 289 year: 2015 ident: hep29683-bib-0039-20241017 article-title: m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.01.016 – volume: 485 start-page: 201 year: 2012 ident: hep29683-bib-0012-20241017 article-title: Topology of the human and mouse m6A RNA methylomes revealed by m6A‐seq publication-title: Nature doi: 10.1038/nature11112 – volume: 16 start-page: 191 year: 2014 ident: hep29683-bib-0022-20241017 article-title: N6‐methyladenosine modification destabilizes developmental regulators in embryonic stem cells publication-title: Nat Cell Biol doi: 10.1038/ncb2902 – volume: 62 start-page: 335 year: 2016 ident: hep29683-bib-0031-20241017 article-title: The m(6)A methyltransferase METTL3 promotes translation in human cancer cells publication-title: Mol Cell doi: 10.1016/j.molcel.2016.03.021 – volume: 47 start-page: 505 year: 2015 ident: hep29683-bib-0002-20241017 article-title: Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets publication-title: Nat Genet doi: 10.1038/ng.3252 – volume: 28 start-page: 29 year: 2001 ident: hep29683-bib-0036-20241017 article-title: SOCS‐1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth‐suppression activity publication-title: Nat Genet doi: 10.1038/ng0501-29 – volume: 37 start-page: 13521 year: 2016 ident: hep29683-bib-0041-20241017 article-title: The suppressor of cytokine signaling 2 (SOCS2) inhibits tumor metastasis in hepatocellular carcinoma publication-title: Tumour Biol doi: 10.1007/s13277-016-5215-7 – volume: 63 start-page: 7646 year: 2003 ident: hep29683-bib-0005-20241017 article-title: Genetic and epigenetic alterations of DLC‐1 gene in hepatocellular carcinoma publication-title: Cancer Res – volume: 347 start-page: 1002 year: 2015 ident: hep29683-bib-0024-20241017 article-title: Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation publication-title: Science doi: 10.1126/science.1261417 – volume: 15 start-page: 293 year: 2014 ident: hep29683-bib-0003-20241017 article-title: Gene expression regulation mediated through reversible m(6)A RNA methylation publication-title: Nat Rev Genet doi: 10.1038/nrg3724 – volume: 24 start-page: 177 year: 2014 ident: hep29683-bib-0015-20241017 article-title: Mammalian WTAP is a regulatory subunit of the RNA N6‐methyladenosine methyltransferase publication-title: Cell Res doi: 10.1038/cr.2014.3 – volume: 113 start-page: E2047 year: 2016 ident: hep29683-bib-0026-20241017 article-title: Hypoxia induces the breast cancer stem cell phenotype by HIF‐dependent and ALKBH5‐mediated m(6)A‐demethylation of NANOG mRNA publication-title: Proc Natl Acad Sci U S A – volume: 61 start-page: 1945 year: 2015 ident: hep29683-bib-0004-20241017 article-title: DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma publication-title: Hepatology doi: 10.1002/hep.27732 – volume: 8 start-page: 176 year: 2013 ident: hep29683-bib-0034-20241017 article-title: Transcriptome‐wide mapping of N(6)‐methyladenosine by m(6)A‐seq based on immunocapturing and massively parallel sequencing publication-title: Nat Protoc doi: 10.1038/nprot.2012.148 – volume: 519 start-page: 482 year: 2015 ident: hep29683-bib-0037-20241017 article-title: N‐6‐methyladenosine marks primary microRNAs for processing publication-title: Nature doi: 10.1038/nature14281 – volume: 7 start-page: 885 year: 2011 ident: hep29683-bib-0017-20241017 article-title: N6‐methyladenosine in nuclear RNA is a major substrate of the obesity‐associated FTO publication-title: Nat Chem Biol doi: 10.1038/nchembio.687 – volume: 45 start-page: 1129 year: 2007 ident: hep29683-bib-0006-20241017 article-title: Tissue factor pathway inhibitor‐2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma publication-title: Hepatology doi: 10.1002/hep.21578 – volume: 56 start-page: 622 year: 2012 ident: hep29683-bib-0008-20241017 article-title: Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis publication-title: Hepatology doi: 10.1002/hep.25679 – volume: 43 start-page: D197 year: 2015 ident: hep29683-bib-0035-20241017 article-title: MeT‐DB: a database of transcriptome methylation in mammalian cells publication-title: Nucleic Acids Res doi: 10.1093/nar/gku1024 – volume: 57 start-page: 637 year: 2013 ident: hep29683-bib-0009-20241017 article-title: Histone lysine methyltransferase, suppressor of variegation 3‐9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA‐125b publication-title: Hepatology doi: 10.1002/hep.26083 – volume: 49 start-page: 18 year: 2013 ident: hep29683-bib-0018-20241017 article-title: ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility publication-title: Mol Cell doi: 10.1016/j.molcel.2012.10.015 – volume: 163 start-page: 999 year: 2015 ident: hep29683-bib-0020-20241017 article-title: 5′ UTR m(6)A promotes cap‐independent translation publication-title: Cell doi: 10.1016/j.cell.2015.10.012 – volume: 19 start-page: 271 year: 1999 ident: hep29683-bib-0001-20241017 article-title: Epidemiology of primary liver cancer publication-title: Semin Liver Dis doi: 10.1055/s-2007-1007117 – volume: 65 start-page: 529 year: 2017 ident: hep29683-bib-0038-20241017 article-title: METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6‐methyladenosine‐dependent primary MicroRNA processing publication-title: Hepatology doi: 10.1002/hep.28885 |
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| SubjectTerms | Adenosine Animals Carcinogenesis Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - etiology Cell migration Cell proliferation Chemical modification Chromatin remodeling CRISPR Disease Progression DNA methylation Epigenetics Gene expression Hepatocellular carcinoma Hepatology Humans Liver cancer Liver Neoplasms - enzymology Liver Neoplasms - etiology Metastases Methyltransferases - physiology Mice mRNA stability N6-methyladenosine Polymerase chain reaction Post-transcription RNA Interference RNA modification RNA-Binding Proteins - physiology Solid tumors Splicing Suppressor of Cytokine Signaling Proteins - genetics Tumorigenicity |
| Title | RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2 |
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