Adipocyte Fatty Acid–Binding Protein Suppresses Cardiomyocyte Contraction: A New Link Between Obesity and Heart Disease

• Published in: Circulation research Vol. 105; no. 4; pp. 326 - 334
• Main Authors: Lamounier-Zepter, Valéria, Look, Christiane, Alvarez, Julio, Christ, Torsten, Ravens, Ursula, Schunck, Wolf-Hagen, Ehrhart-Bornstein, Monika, Bornstein, Stefan R., Morano, Ingo
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 14.08.2009; Lippincott Williams & Wilkins
• Subjects: Action Potentials - drug effects; Adipocytes - secretion; Adult; Aged; Animals; Atherosclerosis - metabolism; Biological and medical sciences; Calcium - metabolism; Calcium Signaling - drug effects; Cardiology. Vascular system; Cells, Cultured; Diabetes Mellitus, Type 2 - metabolism; Dose-Response Relationship, Drug; Fatty Acid-Binding Proteins - isolation & purification; Fatty Acid-Binding Proteins - pharmacology; Fatty Acid-Binding Proteins - secretion; Female; Fundamental and applied biological sciences. Psychology; Heart; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Humans; Male; Medical sciences; Metabolic diseases; Metabolic Syndrome - metabolism; Middle Aged; Myocardial Contraction - drug effects; Myocytes, Cardiac - metabolism; Obesity; Obesity - metabolism; Rats; Rats, Wistar; Vertebrates: cardiovascular system; Endocrinopathy; Heart failure; Adipocyte; Obesity; Nutrition disorder; Lipids; Metabolic diseases; Cardiovascular disease; Metabolic syndrome; Fatty acids; Contraction; Binding protein; Vertebrata; Mammalia; FABP4; Heart disease; Circulatory system; adipocytes; Nutritional status; Heart cell

RATIONALE:Adipocyte fatty acid–binding protein (FABP4) is a member of the intracellular lipid-binding protein family and is predominantly expressed in adipose tissue. Emerging evidence suggests that FABP4 plays a role in some aspects of the metabolic syndrome including the development of type 2 diab...