In vitro and in vivo evaluation and a case report of intense nanosecond pulsed electric field as a local therapy for human malignancies

• Published in: International journal of cancer Vol. 121; no. 3; pp. 675 - 682
• Main Authors: Garon, Edward B., Sawcer, David, Vernier, P. Thomas, Tang, Tao, Sun, Yinghua, Marcu, Laura, Gundersen, Martin A., Koeffler, H. Phillip
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2007; Wiley-Liss
• Subjects: Animals; basal cell carcinoma; Biological and medical sciences; Carcinoma, Basal Cell - therapy; Cell Line, Tumor; Electric Stimulation Therapy - methods; Female; Gastroenterology. Liver. Pancreas. Abdomen; Hematologic Neoplasms - therapy; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Mice; Mice, Nude; nanoelectropulse therapy; Neoplasm Transplantation; Neoplasms - therapy; pancreatic cancer; Pancreatic Neoplasms - therapy; Skin Neoplasms - therapy; Tumor Cells, Cultured; Tumors; Human; Skin disease; Basal cell carcinoma; nanoelectropulse therapy; Malignancy; Malignant tumor; In vitro; Case study; In vivo; pancreatic cancer; Cancerology; Electric field; Treatment; Pancreas cancer; Pulsed field; Digestive diseases; Pancreatic disease
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/ijc.22723

When delivered to cells, very short duration, high electric field pulses (nanoelectropulses) induce primarily intracellular events. We present evidence that this emerging modality may have a role as a local cancer therapy. Five hematologic and 16 solid tumor cell lines were pulsed in vitro. Hematolo...