PI3k/AKT signaling pathway: Erythropoiesis and beyond

• Published in: Journal of cellular physiology Vol. 234; no. 3; pp. 2373 - 2385
• Main Authors: Jafari, Mahjoobeh, Ghadami, Elham, Dadkhah, Tahereh, Akhavan‐Niaki, Haleh
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2019
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Apoptosis; Apoptosis - genetics; Autophagy; Autophagy - genetics; Cell Differentiation - genetics; Cell division; Cell survival; Differentiation; Disorders; Erythrocytes; Erythrocytes - cytology; Erythrocytes - metabolism; Erythropoiesis; Erythropoiesis - genetics; Hematological diseases; Hematopoietic stem cells; Hematopoietic Stem Cells - metabolism; Humans; microRNA (miRNA); MicroRNAs - genetics; miRNA; Phagocytosis; Phosphatidylinositol 3-Kinases - genetics; PI3K; Proto-Oncogene Proteins c-akt - genetics; Signal transduction; Signal Transduction - genetics; Signaling; Stem cells; Transcription factors; PI3K; microRNA (miRNA); erythropoiesis

Erythropoiesis is a multi‐step process that involves the differentiation of hematopoietic stem cells into mature red blood cells (RBCs). This process is regulated by several signaling pathways, transcription factors and microRNAs (miRNAs). Many studies have shown that dysregulation of this process c...