Intracellular glucose starvation inhibits osteogenic differentiation in human periodontal ligament cells

• Published in: Journal of periodontal research Vol. 58; no. 3; pp. 607 - 620
• Main Authors: Deng, Xin, Kato, Hirohito, Taguchi, Yoichiro, Nakata, Takaya, Umeda, Makoto
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2023
• Subjects: Autophagy; Carrier Proteins - metabolism; Cell Differentiation; Cell migration; Cell Proliferation; Cells, Cultured; Glucose; Glucose metabolism; Humans; lactate; Lactates - metabolism; Lactates - pharmacology; Lactic acid; Ligaments; Mesenchyme; Oral cavity; Osteogenesis; osteogenic differentiation; Periodontal Ligament; periodontal ligament cells; Tissue engineering; periodontal ligament cells; lactate; glucose metabolism; osteogenic differentiation

Background Periodontal ligament cells (PDLCs), as mesenchymal cells in the oral cavity, are closely linked to periodontal tissue regeneration. However, the effect of local glucose deficiency on periodontal tissue regeneration, such as immediately post‐surgery, remains unknown. Objective In the prese...