A brief primer on the mediational role of BDNF in the exercise‐memory link
Summary One of the most amazing aspects of the human brain is its ability to learn information and use it to change behaviour. A key neurotrophin that influences memory function is brain‐derived neurotrophic factor (BDNF). This review briefly discusses the mechanistic role that BDNF may play in faci...
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| Published in | Clinical physiology and functional imaging Vol. 39; no. 1; pp. 9 - 14 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Wiley Subscription Services, Inc
01.01.2019
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| Online Access | Get full text |
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| Abstract | Summary
One of the most amazing aspects of the human brain is its ability to learn information and use it to change behaviour. A key neurotrophin that influences memory function is brain‐derived neurotrophic factor (BDNF). This review briefly discusses the mechanistic role that BDNF may play in facilitating learning and memory. We also describe the role of exercise on this relationship. As discussed herein, BDNF may influence memory via BDNF‐induced alterations in membrane receptor expression and translocation, as well as activating several pathways (PLC‐y, PI3K, ERK) that act together to facilitate cellular effects that influence synaptic plasticity. Exercise may help to facilitate BDNF expression and its downstream cellular pathways from both direct and indirect mechanisms. |
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| AbstractList | One of the most amazing aspects of the human brain is its ability to learn information and use it to change behaviour. A key neurotrophin that influences memory function is brain‐derived neurotrophic factor (BDNF). This review briefly discusses the mechanistic role that BDNF may play in facilitating learning and memory. We also describe the role of exercise on this relationship. As discussed herein, BDNF may influence memory via BDNF‐induced alterations in membrane receptor expression and translocation, as well as activating several pathways (PLC‐y, PI3K, ERK) that act together to facilitate cellular effects that influence synaptic plasticity. Exercise may help to facilitate BDNF expression and its downstream cellular pathways from both direct and indirect mechanisms. One of the most amazing aspects of the human brain is its ability to learn information and use it to change behaviour. A key neurotrophin that influences memory function is brain-derived neurotrophic factor (BDNF). This review briefly discusses the mechanistic role that BDNF may play in facilitating learning and memory. We also describe the role of exercise on this relationship. As discussed herein, BDNF may influence memory via BDNF-induced alterations in membrane receptor expression and translocation, as well as activating several pathways (PLC-y, PI3K, ERK) that act together to facilitate cellular effects that influence synaptic plasticity. Exercise may help to facilitate BDNF expression and its downstream cellular pathways from both direct and indirect mechanisms.One of the most amazing aspects of the human brain is its ability to learn information and use it to change behaviour. A key neurotrophin that influences memory function is brain-derived neurotrophic factor (BDNF). This review briefly discusses the mechanistic role that BDNF may play in facilitating learning and memory. We also describe the role of exercise on this relationship. As discussed herein, BDNF may influence memory via BDNF-induced alterations in membrane receptor expression and translocation, as well as activating several pathways (PLC-y, PI3K, ERK) that act together to facilitate cellular effects that influence synaptic plasticity. Exercise may help to facilitate BDNF expression and its downstream cellular pathways from both direct and indirect mechanisms. One of the most amazing aspects of the human brain is its ability to learn information and use it to change behaviour. A key neurotrophin that influences memory function is brain‐derived neurotrophic factor ( BDNF ). This review briefly discusses the mechanistic role that BDNF may play in facilitating learning and memory. We also describe the role of exercise on this relationship. As discussed herein, BDNF may influence memory via BDNF ‐induced alterations in membrane receptor expression and translocation, as well as activating several pathways ( PLC ‐y , PI 3K, ERK ) that act together to facilitate cellular effects that influence synaptic plasticity. Exercise may help to facilitate BDNF expression and its downstream cellular pathways from both direct and indirect mechanisms. Summary One of the most amazing aspects of the human brain is its ability to learn information and use it to change behaviour. A key neurotrophin that influences memory function is brain‐derived neurotrophic factor (BDNF). This review briefly discusses the mechanistic role that BDNF may play in facilitating learning and memory. We also describe the role of exercise on this relationship. As discussed herein, BDNF may influence memory via BDNF‐induced alterations in membrane receptor expression and translocation, as well as activating several pathways (PLC‐y, PI3K, ERK) that act together to facilitate cellular effects that influence synaptic plasticity. Exercise may help to facilitate BDNF expression and its downstream cellular pathways from both direct and indirect mechanisms. |
| Author | Frith, Emily Loprinzi, Paul D. |
| Author_xml | – sequence: 1 givenname: Paul D. orcidid: 0000-0001-7711-4741 surname: Loprinzi fullname: Loprinzi, Paul D. email: pdloprin@olemiss.edu organization: The University of Mississippi – sequence: 2 givenname: Emily surname: Frith fullname: Frith, Emily organization: The University of Mississippi |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29719116$$D View this record in MEDLINE/PubMed |
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One of the most amazing aspects of the human brain is its ability to learn information and use it to change behaviour. A key neurotrophin that... One of the most amazing aspects of the human brain is its ability to learn information and use it to change behaviour. A key neurotrophin that influences... |
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| SubjectTerms | 1-Phosphatidylinositol 3-kinase Animals Behavior, Animal Brain Brain - cytology Brain - metabolism Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism cellular consolidation Exercise Exercise - physiology Exercise - psychology Human performance Humans Learning Memory Neuronal Plasticity Neurons - metabolism physical activity Plastic foam Signal Transduction Synaptic plasticity |
| Title | A brief primer on the mediational role of BDNF in the exercise‐memory link |
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