Inhibition of Connective Tissue Growth Factor Ameliorates Disease in a Murine Model of Rheumatoid Arthritis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 65; no. 6; pp. 1477 - 1486
• Main Authors: Nozawa, Kazuhisa, Fujishiro, Maki, Kawasaki, Mikiko, Yamaguchi, Ayako, Ikeda, Keigo, Morimoto, Shinji, Iwabuchi, Kazuhisa, Yanagida, Mitsuaki, Ichinose, Shouzo, Morioka, Megumi, Ogawa, Hideoki, Takamori, Kenji, Takasaki, Yoshinari, Sekigawa, Iwao
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2013
• Subjects: Animals; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacology; Arthritis, Experimental - drug therapy; Arthritis, Experimental - immunology; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - immunology; Connective Tissue Growth Factor - antagonists & inhibitors; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunoblotting; Immunohistochemistry; Lymphocyte Activation - drug effects; Lymphocyte Activation - immunology; Medical research; Mice; Mice, Inbred DBA; Microarray Analysis; Real-Time Polymerase Chain Reaction

Objective We have shown that connective tissue growth factor (CTGF) plays an important role in the pathogenesis of rheumatoid arthritis (RA). This study was undertaken to evaluate the effects of blockade of the CTGF pathway on the development of collagen‐induced arthritis (CIA) in mice. Methods Arth...