Primary cutaneous follicle center lymphoma of the arm with a novel chromosomal translocation t(12;21)(q13;q22): A case report

• Published in: American journal of hematology Vol. 81; no. 6; pp. 448 - 453
• Main Authors: Jelic, Tomislav M., Berry, Paula K., Jubelirer, Steven J., Plumley, Lisa, Hartel, Paul H., Estalilla, Oscar C., Chang, Ho‐Huang
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2006; Wiley-Liss
• Subjects: Aged; Biological and medical sciences; Chromosome aberrations; Chromosome Painting; Chromosomes, Human, Pair 12 - genetics; Chromosomes, Human, Pair 14 - genetics; Chromosomes, Human, Pair 18 - genetics; Chromosomes, Human, Pair 21 - genetics; Hematologic and hematopoietic diseases; Humans; Karyotyping; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Follicular - genetics; Lymphoma, Follicular - pathology; Lymphoma, T-Cell, Cutaneous - genetics; Lymphoma, T-Cell, Cutaneous - pathology; Male; Medical genetics; Medical sciences; Oncogene Proteins, Fusion - genetics; primary cutaneous B‐cell lymphoma; Skin Neoplasms - genetics; Skin Neoplasms - pathology; translocation t(12;21)(q13;q22); Translocation, Genetic; Chromosomal aberration; Hematology; Malignant hemopathy; Non Hodgkin lymphoma; Case study; Lymphoproliferative syndrome; Primary; Follicular lymphoma; Abnormal chromosome; Skin; translocation t(12;21)(q13;q22); Arm; Chromosome translocation; primary cutaneous B-cell lymphoma
• DOI: 10.1002/ajh.20572
• ISSN: 0361-8609

We report a reciprocal translocation between the long arms of chromosomes 12 and 21, t(12;21)(q13;q22), in a patient with primary cutaneous follicle center lymphoma. Follicle center lymphoma of the skin and follicle center cell lymphoma of the lymph node are morphologically and immunophenotypically very similar. However, the clinical behavior and prognosis of these tumors are different due to the molecular basis of these malignancies. Follicle center cell lymphoma of the lymph node is determined by the presence of a unique translocation between chromosomes 14 and 18, t(14;18)(q32;q21), BCL‐2‐JH gene rearrangement, that is not present in primary cutaneous follicle center lymphomas. Chromosomal translocations in the primary skin lymphomas have not been previously reported. We hope that our discovery of a new translocation t(12:21)(q13q22) will encourage further investigation into the molecular basis of this translocation and other cytogenetic abnormalities in primary cutaneous B‐cell lymphomas. Am. J. Hematol. 81:448–453, 2006. © 2006 Wiley‐Liss, Inc.