Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex–Mediated Activation of the NLRP3 Inflammasome

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 71; no. 1; pp. 109 - 120
• Main Authors: Shin, Min Sun, Kang, Youna, Wahl, Elizabeth R., Park, Hong‐Jai, Lazova, Rossitza, Leng, Lin, Mamula, Mark, Krishnaswamy, Smita, Bucala, Richard, Kang, Insoo
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2019
• Subjects: Antibodies; Antigen-Antibody Complex - immunology; Autoantibodies - immunology; Autoimmune diseases; Blotting, Western; CARD Signaling Adaptor Proteins - immunology; Caspase; Caspase-1; Cell activation; Chronic conditions; Cytometry; Dimensional analysis; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Inflammasomes; Inflammasomes - immunology; Inflammation; Interleukin-1beta - immunology; Interleukins; Intramolecular Oxidoreductases - antagonists & inhibitors; Intramolecular Oxidoreductases - immunology; Leukocyte migration; Lupus; Macrophage migration inhibitory factor; Macrophage Migration-Inhibitory Factors - antagonists & inhibitors; Macrophage Migration-Inhibitory Factors - immunology; Mass Spectrometry; Mass spectroscopy; Monocytes; Monocytes - immunology; NLR Family, Pyrin Domain-Containing 3 Protein - immunology; Patients; Polymerase chain reaction; Receptors; Receptors, Immunologic; Ribonucleoprotein, U1 Small Nuclear - immunology; Ribonucleoproteins (small nuclear); Subgroups; Systemic lupus erythematosus; Western blotting

Objective High‐expression alleles of macrophage migration inhibitory factor (MIF) are linked genetically to the severity of systemic lupus erythematosus (SLE). The U1 small nuclear RNP (snRNP) immune complex containing U1 snRNP and anti–U1 snRNP antibodies, which are found in patients with SLE, acti...