Association of Salmonella Serotypes with Quinolone Resistance in Broilers
Fluoroquinolone is widely used for the treatment of bacterial diseases, and the emergence of quinolone resistance has become a serious concern in recent years, owing to an increase and inappropriate use of antimicrobials. Here, we attempted to understand the differences in the emergence frequency of...
Saved in:
| Published in | Food Safety Vol. 6; no. 4; pp. 156 - 159 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Food Safety Commission, Cabinet Office, Government of Japan
2018
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Fluoroquinolone is widely used for the treatment of bacterial diseases, and the emergence of quinolone resistance has become a serious concern in recent years, owing to an increase and inappropriate use of antimicrobials. Here, we attempted to understand the differences in the emergence frequency of quinolone-resistant bacterial variants in three Salmonella serotypes S. Infantis, S. Schwarzengrund, and S. Manhattan—which are mainly found in broiler industries in Japan. Emergence frequency tests for quinolone-resistant variants using enrofloxacin-containing agar plates and sequence analysis in the quinolone resistance-determining region (QRDR) of gyrA in DNA gyrase were performed. The results showed no significant difference in the emergence frequency among the three serotypes, and most of the resistant variants had mutations in the QRDR region. These findings suggest that differences in the serotypes tested are not associated with the emergence frequency of quinolone-resistant variants. |
|---|---|
| AbstractList | Fluoroquinolone is widely used for the treatment of bacterial diseases, and the emergence of quinolone resistance has become a serious concern in recent years, owing to an increase and inappropriate use of antimicrobials. Here, we attempted to understand the differences in the emergence frequency of quinolone-resistant bacterial variants in three Salmonella serotypes S. Infantis, S. Schwarzengrund, and S. Manhattan—which are mainly found in broiler industries in Japan. Emergence frequency tests for quinolone-resistant variants using enrofloxacin-containing agar plates and sequence analysis in the quinolone resistance-determining region (QRDR) of gyrA in DNA gyrase were performed. The results showed no significant difference in the emergence frequency among the three serotypes, and most of the resistant variants had mutations in the QRDR region. These findings suggest that differences in the serotypes tested are not associated with the emergence frequency of quinolone-resistant variants. Fluoroquinolone is widely used for the treatment of bacterial diseases, and the emergence of quinolone resistance has become a serious concern in recent years, owing to an increase and inappropriate use of antimicrobials. Here, we attempted to understand the differences in the emergence frequency of quinolone-resistant bacterial variants in three Salmonella serotypes S . Infantis, S . Schwarzengrund, and S . Manhattan—which are mainly found in broiler industries in Japan. Emergence frequency tests for quinolone-resistant variants using enrofloxacin-containing agar plates and sequence analysis in the quinolone resistance-determining region (QRDR) of gyrA in DNA gyrase were performed. The results showed no significant difference in the emergence frequency among the three serotypes, and most of the resistant variants had mutations in the QRDR region. These findings suggest that differences in the serotypes tested are not associated with the emergence frequency of quinolone-resistant variants. Fluoroquinolone is widely used for the treatment of bacterial diseases, and the emergence of quinolone resistance has become a serious concern in recent years, owing to an increase and inappropriate use of antimicrobials. Here, we attempted to understand the differences in the emergence frequency of quinolone-resistant bacterial variants in three serotypes . Infantis, . Schwarzengrund, and . Manhattan-which are mainly found in broiler industries in Japan. Emergence frequency tests for quinolone-resistant variants using enrofloxacin-containing agar plates and sequence analysis in the quinolone resistance-determining region (QRDR) of in DNA gyrase were performed. The results showed no significant difference in the emergence frequency among the three serotypes, and most of the resistant variants had mutations in the QRDR region. These findings suggest that differences in the serotypes tested are not associated with the emergence frequency of quinolone-resistant variants. |
| Author | Usui, Masaru Asai, Tetsuo Sugiyama, Michiyo Nakatsuchi, Ayumi Inagaki, Mizuho |
| Author_xml | – sequence: 1 fullname: Nakatsuchi, Ayumi organization: Faculty of Applied Biological Science, Gifu University, 1-1 Yanadigo, Gifu 501-1193, Japan – sequence: 2 fullname: Inagaki, Mizuho organization: Faculty of Applied Biological Science, Gifu University, 1-1 Yanadigo, Gifu 501-1193, Japan – sequence: 3 fullname: Sugiyama, Michiyo organization: United Graduate School of Veterinary Science, Gifu University, 1-1 Yanadigo, Gifu 501-1193, Japan – sequence: 4 fullname: Usui, Masaru organization: School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan – sequence: 5 fullname: Asai, Tetsuo organization: United Graduate School of Veterinary Science, Gifu University, 1-1 Yanadigo, Gifu 501-1193, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31998577$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkU1PGzEQhi1EVT7KX6B77CVge_15qUQRBSqkqqU9WxPvmDja2Km9AeXfd2lCBD2MPNI888543iOyn3JCQj4yesYEl_w85NxVCDisQ_XzM06ZoYzvkUPOjJ4YQcX-q_yAnNQ6p5QyraWl-j05aJm1Rmp9SG4vas0-whBzanJo7qFfjNP6Hpp7LHlYL7E2T3GYNT9WMeV-rDU_scY6QPLYxNR8KTn2WOoH8i5AX_Fk-x6T31-vfl3eTO6-X99eXtxNvGCWTyTlAZUWVAFYDUIqjdIKicCVhw6mPkwVZYHJVnWdQSHbKQj0XlnwhvL2mHze6C5X0wV2HtNQoHfLEhdQ1i5DdG8rKc7cQ350SlvZ2nYU-LQVKPnPCuvgFrH65y8nzKvqeCuMoZYZMaJ6g_qSay0YdmMYdf-8cG-9cFsvxs7T11vu-l4uPwLfNsB8POUD7gAoQ_Q9_q-rnBhjq76D_AyKw9T-BVCHqUI |
| CitedBy_id | crossref_primary_10_3390_antibiotics10070785 crossref_primary_10_1111_jam_15430 crossref_primary_10_1186_s12906_024_04376_7 crossref_primary_10_3390_ani10061049 crossref_primary_10_14252_foodsafetyfscj_D_21_00007 |
| Cites_doi | 10.7883/yoken.JJID.2004.287 10.1017/S0950268812000039 10.1128/AAC.40.4.1009 10.1292/jvms.10-0309 10.1111/j.1574-6976.2002.tb00596.x 10.1093/jac/dkr414 10.1128/AAC.49.2.862-863.2005 10.1128/AAC.43.9.2131 10.1111/j.1348-0421.2007.tb03881.x 10.1093/jac/dkn448 10.1111/zph.12081 10.1128/AAC.50.1.38-42.2006 10.1292/jvms.69.1211 10.1016/j.ijantimicag.2009.07.009 10.1128/AEM.70.6.3618-3623.2004 10.1089/fpd.2009.0438 10.1086/318457 10.3389/fmicb.2013.00053 |
| ContentType | Journal Article |
| Copyright | 2018 Food Safety Commission, Cabinet Office, Government of Japan Food Safety Commission, Cabinet Office, Government of Japan. Food Safety Commission, Cabinet Office, Government of Japan 2018 |
| Copyright_xml | – notice: 2018 Food Safety Commission, Cabinet Office, Government of Japan – notice: Food Safety Commission, Cabinet Office, Government of Japan. – notice: Food Safety Commission, Cabinet Office, Government of Japan 2018 |
| DBID | NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.14252/foodsafetyfscj.2018012 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 2187-8404 |
| EndPage | 159 |
| ExternalDocumentID | 10_14252_foodsafetyfscj_2018012 31998577 article_foodsafetyfscj_6_4_6_2018012_article_char_en |
| Genre | Journal Article |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS JSF JSH KQ8 OK1 RJT RPM RZJ NPM AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c4192-502fe67406aa97a4567e5945ea26cadabcfb601f1536dd8e453ba4ecc69ac8023 |
| IEDL.DBID | RPM |
| ISSN | 2187-8404 |
| IngestDate | Fri Sep 01 02:32:21 EDT 2023 Fri Apr 12 06:28:05 EDT 2024 Wed Jul 17 12:57:09 EDT 2024 Fri Sep 17 23:20:01 EDT 2021 Wed Apr 05 13:39:58 EDT 2023 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 4 |
| Keywords | Salmonella fluoroquinolone quinolone resistance broiler chicken |
| Language | English |
| License | Food Safety Commission, Cabinet Office, Government of Japan. This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4192-502fe67406aa97a4567e5945ea26cadabcfb601f1536dd8e453ba4ecc69ac8023 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this study. The contents of this article reflect solely the view of the author(s). |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795393/ |
| PMID | 31998577 |
| PQID | 2348809184 |
| PQPubID | 23479 |
| PageCount | 4 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6795393 proquest_miscellaneous_2348809184 crossref_primary_10_14252_foodsafetyfscj_2018012 pubmed_primary_31998577 jstage_primary_article_foodsafetyfscj_6_4_6_2018012_article_char_en |
| PublicationCentury | 2000 |
| PublicationDate | 2018 |
| PublicationDateYYYYMMDD | 2018-01-01 |
| PublicationDate_xml | – year: 2018 text: 2018 |
| PublicationDecade | 2010 |
| PublicationPlace | Japan |
| PublicationPlace_xml | – name: Japan |
| PublicationTitle | Food Safety |
| PublicationTitleAlternate | Food Safety |
| PublicationYear | 2018 |
| Publisher | Food Safety Commission, Cabinet Office, Government of Japan |
| Publisher_xml | – name: Food Safety Commission, Cabinet Office, Government of Japan |
| References | 10. Asai T, Ishihara K, Harada K, et al. Long-term prevalence of antimicrobial-resistant Salmonella enterica subspecies enterica Serovar infantis in the broiler chicken industry in Japan. Microbiol Immunol. 2007; 51: 111–115. PMID:17237606, DOI:10.1111/j.1348-0421.2007.tb03881.x 16. Fey A, Eichler S, Flavier S, Christen R, Höfle MG, Guzmán CA. Establishment of a real-time PCR-based approach for accurate quantification of bacterial RNA targets in water, using Salmonella as a model organism. Appl Environ Microbiol. 2004; 70: 3618–3623. PMID:15184165, DOI:10.1128/AEM.70.6.3618-3623.2004 5. Griggs DJ, Gensberg K, Piddock LJ. Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals. Antimicrob Agents Chemother. 1996; 40: 1009–1013. PMID:8849216, DOI:10.1128/AAC.40.4.1009 9. Noda T, Murakami K, Ishiguro Y, Asai T. Chicken meat is an infection source of Salmonella serovar Infantis for humans in Japan. Foodborne Pathog Dis. 2010; 7: 727–735. PMID:20141347, DOI:10.1089/fpd.2009.0438 6. Ricci V, Tzakas P, Buckley A, Piddock LJV. Ciprofloxacin-resistant Salmonella enterica serovar Typhimurium strains are difficult to select in the absence of AcrB and TolC. Antimicrob Agents Chemother. 2006; 50: 38–42. PMID:16377664, DOI:10.1128/AAC.50.1.38-42.2006 12. Akiyama T, Khan AA. Molecular characterization of strains of fluoroquinolone-resistant Salmonella enterica serovar Schwarzengrund carrying multidrug resistance isolated from imported foods. J Antimicrob Chemother. 2012; 67: 101–110. PMID:22010209, DOI:10.1093/jac/dkr414 18. Velhner M, Kozoderović G, Grego E, et al. Clonal spread of Salmonella enterica serovar Infantis in Serbia: acquisition of mutations in the topoisomerase genes gyrA and parC leads to increased resistance to fluoroquinolones. Zoonoses Public Health. 2014; 61: 364–370. PMID:24119387, DOI:10.1111/zph.12081 7. Zheng J, Cui S, Meng J. Effect of transcriptional activators RamA and SoxS on expression of multidrug efflux pumps AcrAB and AcrEF in fluoroquinolone-resistant Salmonella Typhimurium. J Antimicrob Chemother. 2009; 63: 95–102. PMID:18984645, DOI:10.1093/jac/dkn448 13. Baucheron S, Chaslus-Dancla E, Cloeckaert A, Chiu CH, Butaye P. High-level resistance to fluoroquinolones linked to mutations in gyrA, parC, and parE in Salmonella enterica serovar Schwarzengrund isolates from humans in Taiwan. Antimicrob Agents Chemother. 2005; 49: 862–863. PMID:15673791, DOI:10.1128/AAC.49.2.862-863.2005 8. Usui M, Uchiyama M, Iwanaka M, Nagai H, Yamamoto Y, Asai T. Intracellular concentrations of enrofloxacin in quinolone-resistant Salmonella enterica subspecies enterica serovar Choleraesuis. Int J Antimicrob Agents. 2009; 34: 592–595. PMID:19733466, DOI:10.1016/j.ijantimicag.2009.07.009 2. Esaki H, Chiu CH, Kojima A, et al. Comparison of fluoroquinolone resistance genes of Salmonella enterica serovar Choleraesuis isolates in Japan and Taiwan. Jpn. J. Infect. Dis. 2004; 57: 287–288. PMID:15623959 4. Piddock LJV. Fluoroquinolone resistance in Salmonella serovars isolated from humans and food animals. FEMS Microbiol Rev. 2002; 26: 3–16. PMID:12007640, DOI:10.1111/j.1574-6976.2002.tb00596.x 17. Usui M, Uchiyama M, Baba K, Nagai H, Yamamoto Y, Asai T. Contribution of enhanced efflux to reduced susceptibility of Salmonella enterica serovar Choleraesuis to fluoroquinolone and other antimicrobials. J Vet Med Sci. 2011; 73: 279–282. PMID:20953129, DOI:10.1292/jvms.10-0309 14. Giraud E, Brisabois A, Martel JL, Chaslus-Dancla E. Comparative studies of mutations in animal isolates and experimental in vitro- and in vivo-selected mutants of Salmonella spp. suggest a counterselection of highly fluoroquinolone-resistant strains in the field. Antimicrob Agents Chemother. 1999; 43: 2131–2137. PMID:10471553, DOI:10.1128/AAC.43.9.2131 1. Acheson D, Hohmann EL. Nontyphoidal Salmonellosis. Clin Infect Dis. 2001; 32: 263–269. PMID:11170916, DOI:10.1086/318457 3. Kawagoe K, Mine H, Asai T, et al. Changes of multi-drug resistance pattern in Salmonella enterica subspecies enterica serovar typhimurium isolates from food-producing animals in Japan. J Vet Med Sci. 2007; 69: 1211–1213. PMID:18057843, DOI:10.1292/jvms.69.1211 11. Sasaki Y, Ikeda A, Ishikawa K, et al. Prevalence and antimicrobial susceptibility of Salmonella in Japanese broiler flocks. Epidemiol Infect. 2012; 140: 2074–2081. PMID:22281015, DOI:10.1017/S0950268812000039 15. Usui M, Nagai H, Hiki M, Tamura Y, Asai T. Effect of antimicrobial exposure on AcrAB expression in Salmonella enterica subspecies enterica serovar Choleraesuis. Front Microbiol. 2013; 4: 53. PMID:23503095, DOI:10.3389/fmicb.2013.00053 11 12 13 14 15 16 17 18 1 2 3 4 5 6 7 8 9 10 |
| References_xml | – ident: 2 doi: 10.7883/yoken.JJID.2004.287 – ident: 11 doi: 10.1017/S0950268812000039 – ident: 5 doi: 10.1128/AAC.40.4.1009 – ident: 17 doi: 10.1292/jvms.10-0309 – ident: 4 doi: 10.1111/j.1574-6976.2002.tb00596.x – ident: 12 doi: 10.1093/jac/dkr414 – ident: 13 doi: 10.1128/AAC.49.2.862-863.2005 – ident: 14 doi: 10.1128/AAC.43.9.2131 – ident: 10 doi: 10.1111/j.1348-0421.2007.tb03881.x – ident: 7 doi: 10.1093/jac/dkn448 – ident: 18 doi: 10.1111/zph.12081 – ident: 6 doi: 10.1128/AAC.50.1.38-42.2006 – ident: 3 doi: 10.1292/jvms.69.1211 – ident: 8 doi: 10.1016/j.ijantimicag.2009.07.009 – ident: 16 doi: 10.1128/AEM.70.6.3618-3623.2004 – ident: 9 doi: 10.1089/fpd.2009.0438 – ident: 1 doi: 10.1086/318457 – ident: 15 doi: 10.3389/fmicb.2013.00053 |
| SSID | ssj0001775907 |
| Score | 1.6845489 |
| Snippet | Fluoroquinolone is widely used for the treatment of bacterial diseases, and the emergence of quinolone resistance has become a serious concern in recent years,... Fluoroquinolone is widely used for the treatment of bacterial diseases, and the emergence of quinolone resistance has become a serious concern in recent years,... |
| SourceID | pubmedcentral proquest crossref pubmed jstage |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 156 |
| SubjectTerms | broiler chicken fluoroquinolone quinolone resistance Salmonella Short Communication |
| Title | Association of Salmonella Serotypes with Quinolone Resistance in Broilers |
| URI | https://www.jstage.jst.go.jp/article/foodsafetyfscj/6/4/6_2018012/_article/-char/en https://www.ncbi.nlm.nih.gov/pubmed/31998577 https://search.proquest.com/docview/2348809184 https://pubmed.ncbi.nlm.nih.gov/PMC6795393 |
| Volume | 6 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Food Safety, 2018, Vol.6(4), pp.156-159 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT8MwDLbYhBAXBOJVXgoS126lbZL1iCamgQTiKXGrkjSFTaNF63bg32P3MW2IE4eemjSJ7difHccFuPCTSEvBtYvYlruh8rWrEJa6CMY9qq8WJAkF9O_uxfA1vH3jb2vAm7swZdK-0aNONvnsZKOPMrfy69N0mzyx7sNdX8iIB1HQbUELBXTJRS8DK1Jy9PjqXC6cgd9N8zwpVGpn32hXxpTPRXp5EzYCumHGpVwxSutjxGXv9i_I-TtzcskUDbZhq8aQ7Kqa6w6s2WwXbpYIzfKUPasJShjlNjHUBzmFWgtGUVf2OB9RMD2z7MkWBB-R72yUMfTIUUVMiz14HVy_9Idu_Z8E19AZrss9P7VComlWKpIKIZG0PAq5Vb4wKlHapBr9rhSVm0iSng15oFWIvBORMlQAbh_aGY56CEx7Ke8lGnGZ4aHUlz2DX4iUNNp6VmvhgNcQKv6qymHE5EYQmeNVMsc1mR3oVwRddKhZ-bu9iEN86l6LRnT5DHewA-cNN2LcAHSqoTKbz4vYD0gHReipOnBQcWcxUsNfB-QK3xYNqLj26huUubLIdi1jR__ueQybtJYqXHMC7dl0bk8RwMz0WSmwP0RD9yw |
| link.rule.ids | 230,315,730,783,787,888,4033,27937,27938,27939,53806,53808 |
| linkProvider | National Library of Medicine |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT-MwEB4Bi4ALuytgyfLySlzThiS2myOqQGWXouUpbpHtOGx5JIi0B_bXM5NH1VZc4JCT7STON575ZjyeAOz7SaSl4NpFbsvdUPnaVUhLXSTjHtVXC5KEAvr9M9G7Dn_f8ts54M1ZmDJp3-hBK3t8amWDf2Vu5fOTaTd5Yu2__a6QEQ-ioD0PX3C9emLCSS9DK1Jy9PnqbC58B7-d5nlSqNQOX9Gy3FNGF2nmFVgK6IwZl3LKLC3eIzO7s--RztncyQljdPwVbpppVDkoD63RULfM_5kKjx-e5zdYrekpO6yav8OczdbgZAJDlqfsUj2i8FLaFENVk1MUt2AU0GXnowHF6TPLLmxBzBRFig0yhs4-ap-XYh2uj4-uuj23_gWDa2h72OWen1oh0eorFUmFbEtaHoXcKl8YlShtUo0uXYp6UyRJx4Y80CpEsRCRMlRbbgMWMnzqJjDtpbyTaKR8hodSH3QM3iFS0mjrWa2FA16DQPxcVdqIyUMh_OJp_OIaPwe6FVLjAfXXm-0v4hCvetS4E51rQ-XgwK8G5hjXFm2YqMzmoyL2A1JvETrBDvyoYB8_qREcB-SUQIw7UN3u6RaEuazfXcP689Mj92C5d9U_jU9Pzv5swQrNq4oKbcPC8GVkd5AnDfVuuSreAAeFGT0 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9swDCbWrihy2Va0Xb2nCvTq2LMtKT4O2YJ2a4s-gaIXQy9v6cMO6uSw_fqRfgRJsFMPPlmyLX8U-ZGiKICDyKZaCq595LbcT1SkfYW01EcyHlJ9tdhaCuifnIrD6-THDb9ZOOqrTto3etwvHh77xfh3nVs5eTRBlycWnJ0MhUx5nMbBxObBGrzEORsOFhz1OrwiJUe_r83owu-IgrwsbaVyN_2D1uWOsrpIO_dgM6Z9ZlzKJdO0cYfs7Jf7H_FczZ9cMEij13DbDaXJQ7nvz6a6b_6uVHl81ljfwKuWprKvTZMteOGKbThawJKVObtUDyjElD7FUOWUFM2tGAV22flsTPH6wrELVxFDRdFi44Kh049a6KnagevR96vhod8exeAbWib2eRjlTki0_kqlUiHrko6nCXcqEkZZpU2u0bXLUX8Kawcu4bFWCYqHSJWhGnO7sF7gW_eA6TDnA6uR-hmeSP1lYPAJqZJGu9BpLTwIOxSySVNxIyNPhTDMljHMWgw9GDZozTu0f3C1vcgSvNpe80a0vw2VhAf7HdQZzjFaOFGFK2dVFsWk5lJ0hj1420A_f1MnPB7IJaGYN6D63ct3EOq6jncL7btn9_wMm2ffRtnx0enP99CjYTXBoQ-wPn2auY9Il6b6Uz0x_gGckBu9 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+of+Salmonella+Serotypes+with+Quinolone+Resistance+in+Broilers&rft.jtitle=Food+Safety&rft.au=Nakatsuchi%2C+Ayumi&rft.au=Inagaki%2C+Mizuho&rft.au=Sugiyama%2C+Michiyo&rft.au=Usui%2C+Masaru&rft.date=2018&rft.pub=Food+Safety+Commission%2C+Cabinet+Office%2C+Government+of+Japan&rft.eissn=2187-8404&rft.volume=6&rft.issue=4&rft.spage=156&rft.epage=159&rft_id=info:doi/10.14252%2Ffoodsafetyfscj.2018012&rft.externalDocID=article_foodsafetyfscj_6_4_6_2018012_article_char_en |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2187-8404&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2187-8404&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2187-8404&client=summon |