Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin - Zhang, Xuefei; Sui, Shiyao; Wang, Lingling; Li, Haixia; Zhang, Lei; Xu, Shouping; Zheng, Xiulan (Journal of cellular physiology, 2020)
Keywords: A549 Cells; Animals; Anticancer properties; Antineoplastic drugs; Antitumor agents; authphagy; Cancer; Carbamates - pharmacology; Cell Movement - drug effects; Chemoresistance; Chemotherapy; Cisplatin; Cisplatin - pharmacology; Dipeptides - pharmacology; DNA methylation; DNA Methylation - drug effects; Drugs; Electron transport; Electron transport chain; Epigenesis, Genetic - drug effects; Epigenetics; Fatty liver; Ferroptosis; Ferroptosis - drug effects; Ferroptosis - genetics; Glutathione; Glutathione peroxidase; GPX4; Heterografts; Histones - genetics; Humans; Inhibitor drugs; Lapatinib - pharmacology; Liver diseases; lung cancer; Medical prognosis; Metabolic pathways; Mice; Mitochondria; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Oxidative phosphorylation; pan‐cancer; Peroxidase; Phospholipid Hydroperoxide Glutathione Peroxidase - genetics; Phosphorylation; Piperazines - pharmacology; Pyridines - pharmacology; Topotecan; Topotecan - pharmacology; lung cancer; ferroptosis; pan-cancer; GPX4; cisplatin; authphagy