Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi‐Omics

• Published in: Annals of neurology Vol. 89; no. 3; pp. 546 - 559
• Main Authors: Tan, Ai Huey, Chong, Chun Wie, Lim, Shen‐Yang, Yap, Ivan Kok Seng, Teh, Cindy Shuan Ju, Loke, Mun Fai, Song, Sze‐Looi, Tan, Jiun Yan, Ang, Ban Hong, Tan, Yong Qi, Kho, Mee Teck, Bowman, Jeff, Mahadeva, Sanjiv, Yong, Hoi Sen, Lang, Anthony E.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2021; Wiley Subscription Services, Inc
• Subjects: Aged; Biological activity; Biomarkers; Body mass; Body mass index; Body size; Ceramides - metabolism; Chromatography, Liquid; Cognition; Cognitive ability; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - microbiology; Constipation; Constipation - metabolism; Constipation - microbiology; Environmental changes; Fatty acids; Fatty Acids, Volatile - metabolism; Fecal microflora; Feces; Feces - chemistry; Female; Frailty - metabolism; Frailty - microbiology; Gait; Gastrointestinal Microbiome - genetics; Gene sequencing; Humans; Intestinal microflora; Liquid chromatography; Male; Mass Spectrometry; Mass spectroscopy; Metabolites; Metabolomics; Methylamines - metabolism; Microbial activity; Microbiomes; Microorganisms; Middle Aged; Movement disorders; Neurodegeneration; Neurodegenerative diseases; Neuroprotection; NMR; NMR spectroscopy; Nuclear magnetic resonance; Parkinson Disease - metabolism; Parkinson Disease - microbiology; Parkinson's disease; Phenotyping; Physical activity; Proton Magnetic Resonance Spectroscopy; RNA, Ribosomal, 16S - genetics; rRNA 16S; Salicylates - metabolism; Salicylic acid; Sedentary Behavior; Sphingosine - metabolism; Thinness - metabolism; Thinness - microbiology; Trimethylamine; Ubiquinone - metabolism

Objective Gut microbiome alterations in Parkinson disease (PD) have been reported repeatedly, but their functional relevance remains unclear. Fecal metabolomics, which provide a functional readout of microbial activity, have scarcely been investigated. We investigated fecal microbiome and metabolome...