Effect of dietary fish oil on development and selected functions of murine inflammatory macrophages

• Published in: Journal of leukocyte biology Vol. 49; no. 6; pp. 592 - 598
• Main Authors: Hubbard, Neil E., Somers, Scott D., Erickson, Kent L.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Society for Leukocyte Biology 01.06.1991; Federation of American Societies for Experimental Biology
• Subjects: activational state; Administration, Oral; Animals; Biological and medical sciences; Cell Adhesion - drug effects; Cell Adhesion - physiology; Cell Movement - drug effects; Cell Movement - physiology; Cells, Cultured; Dietary Fats, Unsaturated - administration & dosage; Dietary Fats, Unsaturated - pharmacology; docosahexaenoic acid; Dose-Response Relationship, Drug; eicosapentaenoic acid; Female; Fish Oils - administration & dosage; Fish Oils - pharmacology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Histocompatibility Antigens Class II - metabolism; Immunobiology; Inflammation - pathology; Inflammation - physiopathology; Interferon-gamma - pharmacology; la expression; Lipopolysaccharides - pharmacology; Macrophages - drug effects; Macrophages - pathology; Macrophages - physiology; Mice; Modulation of the immune response (stimulation, suppression); peroxide production; Peroxides - metabolism; Phagocytosis - drug effects; Phagocytosis - physiology; Safflower Oil - administration & dosage; Safflower Oil - pharmacology; Tetradecanoylphorbol Acetate - pharmacology; Zymosan - pharmacology; Cell function; Immunomodulation; Induction; Rodentia; Cytokine; Biosynthesis; Inflammation; Fish oil; Vertebrata; Mammalia; Mouse; Restricted diet; Hydrogen peroxides; Gamma interferon; Macrophage

Inflammatory macrophages from mice fed diets containing menhaden fish oil (MFO) have a reduced capacity for cytotoxicity of mastocytoma cells upon activation with interferon‐γ (IFNγ) and lipopolysaccharide due to an altered responsiveness to IFNγ. In an effort to elucidate further how dietary MFO ef...