An Association Between Core Mutations in Hepatitis B Virus Genotype F1b and Hepatocellular Carcinoma in Alaskan Native People

• Published in: Hepatology (Baltimore, Md.) Vol. 69; no. 1; pp. 19 - 33
• Main Authors: Hayashi, Sanae, Khan, Anis, Simons, Brenna C., Homan, Chriss, Matsui, Takeshi, Ogawa, Kenji, Kawashima, Keigo, Murakami, Shuko, Takahashi, Satoru, Isogawa, Masanori, Ikeo, Kazuho, Mizokami, Masashi, McMahon, Brian J., Tanaka, Yasuhito
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.01.2019
• Subjects: Adolescent; Adult; Aged; Alaska; Bradykinin; Carcinogenesis; Carcinoma, Hepatocellular - complications; Carcinoma, Hepatocellular - virology; Cell proliferation; Child; Child, Preschool; Chronic infection; Core protein; Dimerization; DNA microarrays; Fibrosis; Follistatin; Genotype; Genotype & phenotype; Genotypes; Grb2 protein; Hepatitis; Hepatitis B; Hepatitis B surface antigen; Hepatitis B virus - classification; Hepatitis B virus - genetics; Hepatitis B, Chronic - complications; Hepatocellular carcinoma; Hepatocytes; Hepatology; Humans; Indigenous Peoples; Infant; Infections; Kinases; Liver cancer; Liver Neoplasms - complications; Liver Neoplasms - virology; Middle Aged; Mutation; Myc protein; Protein kinase; Proteins; Young Adult; Alaska

Hepatitis B virus (HBV) genotype F1b infection is strongly associated with hepatocellular carcinoma (HCC) in young Alaskan Native (AN) people. However, the mechanisms by which genotype F1b causes HCC are unclear. Here, we analyzed the clinical and virological significance of genotype F1b in long‐ter...