Activation of Matrix Metalloproteinases 2, 9, and 13 by Activated Protein C in Human Osteoarthritic Cartilage Chondrocytes

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 66; no. 6; pp. 1525 - 1536
• Main Authors: Jackson, Miriam T., Moradi, Babak, Smith, Margaret M., Jackson, Christopher J., Little, Christopher B.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2014
• Subjects: Aged; Aged, 80 and over; Aggrecans - metabolism; Cartilage, Articular - drug effects; Cartilage, Articular - metabolism; Cartilage, Articular - pathology; Cells, Cultured; Chondrocytes - drug effects; Chondrocytes - metabolism; Chondrocytes - pathology; Collagen - metabolism; Disease Progression; Female; Gene expression; Humans; Male; Matrix Metalloproteinase 13 - metabolism; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; Osteoarthritis, Knee - metabolism; Osteoarthritis, Knee - pathology; Proteases; Protein C - pharmacology; Proteins; Serine Proteases - metabolism; Synovial Fluid - metabolism; Tissue Inhibitor of Metalloproteinase-1 - metabolism; Tissue Inhibitor of Metalloproteinase-3 - metabolism

Objective Levels of activated protein C (APC) are elevated in the synovial fluid of patients with osteoarthritis (OA), and increased APC levels are correlated with the levels of active matrix metalloproteinase 2 (MMP‐2). This study sought to investigate whether APC is a relevant protein for activati...