Possible Impact of RET Polymorphism and Its Haplotypic Association Modulates the Susceptibility to Thyroid Cancer

• Published in: Journal of cellular biochemistry Vol. 116; no. 8; pp. 1712 - 1718
• Main Authors: Khan, Mosin S., Pandith, Arshad A., Iqbal, Mohammad, Naykoo, Niyaz A., Khan, Shoukat H., Rather, Tanveer A., Mudassar, Syed
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.08.2015; Wiley Subscription Services, Inc
• Subjects: Adenocarcinoma, Follicular - genetics; Adenocarcinoma, Follicular - pathology; Adult; Alleles; BENIGN THYROID DISEASE; Cancer; Carcinoma - genetics; Carcinoma - pathology; Carcinoma, Papillary; Female; Gene frequency; Gene polymorphism; Genetic Association Studies - methods; Genetic Predisposition to Disease; Haplotypes; Heredity; Heterozygotes; Homozygotes; Humans; Male; Middle Aged; Papillary thyroid cancer; Polygenic inheritance; Polymerase chain reaction; Polymorphism; Polymorphism, Genetic; Proto-Oncogene Proteins c-ret - genetics; REARRANGED DURING TRANSFECTION; Restriction fragment length polymorphism; Ret protein; Risk factors; Smoking; Thyroid; THYROID CANCER; Thyroid diseases; Thyroid Neoplasms - genetics; Thyroid Neoplasms - pathology; THYROID STIMULATING HORMONE; Transfection; Young Adult; BENIGN THYROID DISEASE; REARRANGED DURING TRANSFECTION; THYROID CANCER; THYROID STIMULATING HORMONE

ABSTRACT Rearranged during Transfection (RET) gene polymorphisms act to influence thyroid cancer in a polygenic and low‐penetrance manner and no study regarding RET alterations in thyroid cancer has undergone from this part of the world (North India). We evaluated RET G691S (rs1799939), L769L (rs180...