Implication of basal lamina dependency in survival of Nrf2‐null muscle stem cells via an antioxidative‐independent mechanism
Nuclear factor erythroid 2–related factor 2 (Nrf2) is a master regulator for the induction of antioxidative genes and plays roles in diverse cellular functions. The roles of Nrf2 in muscle regeneration have been investigated, and both important and unimportant roles of Nrf2 for muscle regeneration h...
Saved in:
Published in | Journal of cellular physiology Vol. 234; no. 2; pp. 1689 - 1698 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Wiley Subscription Services, Inc
01.02.2019
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Nuclear factor erythroid 2–related factor 2 (Nrf2) is a master regulator for the induction of antioxidative genes and plays roles in diverse cellular functions. The roles of Nrf2 in muscle regeneration have been investigated, and both important and unimportant roles of Nrf2 for muscle regeneration have been reported. Here, using aged Nrf2‐null and Nrf2–dystrophic double‐null mice, we showed nonsignificant phenotypes in the muscle regeneration ability of Nrf2‐null mice. In contrast with these results, strikingly, almost all Nrf2‐null muscle stem cells (MuSCs) isolated by fluorescence‐activated cell sorting died in vitro of apoptosis and were not rescued by antioxidative reagents. Although their proliferation was still impaired, the Nrf2‐null MuSCs attached to myofibers activated and divided normally, at least in the first round. To elucidate these discrepancies of MuSCs behaviors, we focused on the basal lamina, because both in vivo and single myofiber culture allow MuSCs within the basal lamina to become activated. In a basal lamina–disrupted model, Nrf2‐null mice exhibited remarkable regeneration defects without increased levels of reactive oxidative species in MuSCs, suggesting that the existence of the basal lamina affects the survival of Nrf2‐null MuSCs. Taken together, these results suggest that the basal lamina compensates for the loss of Nrf2, independent of the antioxidative roles of Nrf2. In addition, experimental conditions might explain the discrepant results of Nrf2‐null regenerative ability.
Muscle regeneration ability of Nrf2‐null mice is normal. However, in a basal lamina–disrupted model, Nrf2‐null mice exhibited remarkable regeneration defects without increased levels of reactive oxidative species in muscle stem cells |
---|---|
AbstractList | Nuclear factor erythroid 2–related factor 2 (Nrf2) is a master regulator for the induction of antioxidative genes and plays roles in diverse cellular functions. The roles of Nrf2 in muscle regeneration have been investigated, and both important and unimportant roles of Nrf2 for muscle regeneration have been reported. Here, using aged Nrf2‐null and Nrf2–dystrophic double‐null mice, we showed nonsignificant phenotypes in the muscle regeneration ability of Nrf2‐null mice. In contrast with these results, strikingly, almost all Nrf2‐null muscle stem cells (MuSCs) isolated by fluorescence‐activated cell sorting died in vitro of apoptosis and were not rescued by antioxidative reagents. Although their proliferation was still impaired, the Nrf2‐null MuSCs attached to myofibers activated and divided normally, at least in the first round. To elucidate these discrepancies of MuSCs behaviors, we focused on the basal lamina, because both in vivo and single myofiber culture allow MuSCs within the basal lamina to become activated. In a basal lamina–disrupted model, Nrf2‐null mice exhibited remarkable regeneration defects without increased levels of reactive oxidative species in MuSCs, suggesting that the existence of the basal lamina affects the survival of Nrf2‐null MuSCs. Taken together, these results suggest that the basal lamina compensates for the loss of Nrf2, independent of the antioxidative roles of Nrf2. In addition, experimental conditions might explain the discrepant results of Nrf2‐null regenerative ability. Nuclear factor erythroid 2–related factor 2 (Nrf2) is a master regulator for the induction of antioxidative genes and plays roles in diverse cellular functions. The roles of Nrf2 in muscle regeneration have been investigated, and both important and unimportant roles of Nrf2 for muscle regeneration have been reported. Here, using aged Nrf2‐null and Nrf2–dystrophic double‐null mice, we showed nonsignificant phenotypes in the muscle regeneration ability of Nrf2‐null mice. In contrast with these results, strikingly, almost all Nrf2‐null muscle stem cells (MuSCs) isolated by fluorescence‐activated cell sorting died in vitro of apoptosis and were not rescued by antioxidative reagents. Although their proliferation was still impaired, the Nrf2‐null MuSCs attached to myofibers activated and divided normally, at least in the first round. To elucidate these discrepancies of MuSCs behaviors, we focused on the basal lamina, because both in vivo and single myofiber culture allow MuSCs within the basal lamina to become activated. In a basal lamina–disrupted model, Nrf2‐null mice exhibited remarkable regeneration defects without increased levels of reactive oxidative species in MuSCs, suggesting that the existence of the basal lamina affects the survival of Nrf2‐null MuSCs. Taken together, these results suggest that the basal lamina compensates for the loss of Nrf2, independent of the antioxidative roles of Nrf2. In addition, experimental conditions might explain the discrepant results of Nrf2‐null regenerative ability. Muscle regeneration ability of Nrf2‐null mice is normal. However, in a basal lamina–disrupted model, Nrf2‐null mice exhibited remarkable regeneration defects without increased levels of reactive oxidative species in muscle stem cells |
Author | Fukada, So‐ichiro Uezumi, Akiyoshi Takemoto, Yusei Zhang, Lidan Tsujikawa, Kazutake Inaba, Shoya |
Author_xml | – sequence: 1 givenname: Yusei surname: Takemoto fullname: Takemoto, Yusei organization: Graduate School of Pharmaceutical Sciences, Osaka University – sequence: 2 givenname: Shoya surname: Inaba fullname: Inaba, Shoya organization: Graduate School of Pharmaceutical Sciences, Osaka University – sequence: 3 givenname: Lidan surname: Zhang fullname: Zhang, Lidan organization: Graduate School of Pharmaceutical Sciences, Osaka University – sequence: 4 givenname: Kazutake surname: Tsujikawa fullname: Tsujikawa, Kazutake organization: Graduate School of Pharmaceutical Sciences, Osaka University – sequence: 5 givenname: Akiyoshi surname: Uezumi fullname: Uezumi, Akiyoshi organization: Tokyo Metropolitan Institute of Gerontology – sequence: 6 givenname: So‐ichiro orcidid: 0000-0003-4051-5108 surname: Fukada fullname: Fukada, So‐ichiro email: fukada@phs.osaka-u.ac.jp organization: Graduate School of Pharmaceutical Sciences, Osaka University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30070693$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kc9qVDEUh4NU7LS66AuUgBtd3PYkuX8myzJorRR1oeuQm5zQDEnu7c3c0dn1EXzGPomp07ooCAcOnN_Hx4HfETlIQ0JCThicMQB-vjbjGe-ghhdkwUB2Vd02_IAsSsYq2dTskBzlvAYAKYV4RQ4FQAetFAtydxXH4I3e-CHRwdFeZx1o0NEnTS2OmCwms6M-0TxPW78tacG-TI7f3_1Ocwg0ztkEpHmDkRoMIdOt11SnMsX6y9si32KhfXoSbmhEc6OTz_E1eel0yPjmcR-THx8_fF99qq6_Xl6tLq4rUzMJFXLeNa6veylk21rW2toa0TmtmXO96Y1Ftixn0zZWcIY1cnCFY-1S18I6cUze7b3jNNzOmDcq-vzwrk44zFlxWHKQvGuhoG-foethnlL5TnEmmkbKJZOFer-nzDTkPKFT4-SjnnaKgXqoRZVa1N9aCnv6aJz7iPYf-dRDAc73wE8fcPd_k_q8-rZX_gFhRZw- |
CitedBy_id | crossref_primary_10_1186_s13395_020_00255_0 crossref_primary_10_1186_s13395_022_00300_0 crossref_primary_10_1016_j_devcel_2024_03_017 crossref_primary_10_1113_EP088937 crossref_primary_10_3390_cells11203321 crossref_primary_10_1016_j_freeradbiomed_2020_10_001 crossref_primary_10_1016_j_bbamcr_2020_118742 crossref_primary_10_1155_2019_2601394 crossref_primary_10_1089_ars_2022_0208 crossref_primary_10_3390_cells10113028 crossref_primary_10_3390_ijms20133269 |
Cites_doi | 10.1016/j.cell.2005.05.010 10.1038/srep38371 10.1007/BF02634119 10.1126/science.1087573 10.1242/dev.067165 10.1523/JNEUROSCI.09-08-02678.1989 10.1073/pnas.0611732104 10.1002/stem.773 10.1002/stem.775 10.1371/journal.pone.0138517 10.1152/physrev.00019.2003 10.1016/j.stemcr.2017.12.013 10.3389/fphys.2013.00317 10.1113/jphysiol.2007.148338 10.1016/j.stem.2015.11.005 10.1074/jbc.M115.653477 10.1016/j.celrep.2015.08.083 10.1007/978-1-59745-060-7_19 10.1038/ncomms11624 10.1093/hmg/ddh190 10.1128/MCB.01408-13 10.1083/jcb.9.2.493 10.1016/j.bbrc.2006.01.037 10.1242/dev.112557 10.1002/(SICI)1097-4598(199612)19:12<1549::AID-MUS4>3.0.CO;2-A 10.1038/nrm3591 10.1006/bbrc.1997.6943 10.1016/j.yexcr.2004.02.018 10.1096/fj.201500153 |
ContentType | Journal Article |
Copyright | 2018 Wiley Periodicals, Inc. |
Copyright_xml | – notice: 2018 Wiley Periodicals, Inc. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TK 7U7 8FD C1K FR3 K9. P64 RC3 7X8 |
DOI | 10.1002/jcp.27040 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Neurosciences Abstracts Toxicology Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Genetics Abstracts Technology Research Database Toxicology Abstracts ProQuest Health & Medical Complete (Alumni) Engineering Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
DatabaseTitleList | CrossRef Genetics Abstracts MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology Biology |
EISSN | 1097-4652 |
EndPage | 1698 |
ExternalDocumentID | 10_1002_jcp_27040 30070693 JCP27040 |
Genre | article Research Support, Non-U.S. Gov't Journal Article Comparative Study |
GrantInformation_xml | – fundername: JSPS KAKENHI grant, Grant‐in Aid for Scientific Research (B) funderid: 16H03262 – fundername: AMED funderid: 18am0101084j0002 – fundername: Intramural Research Grant for Neurological and Psychiatric Disorders of NCNP funderid: 25‐5 |
GroupedDBID | --- -DZ -~X .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 31~ 33P 36B 3O- 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5GY 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 85S 8UM 930 9M8 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEFU ABEML ABIJN ABJNI ABPPZ ABPVW ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACNCT ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AETEA AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHMBA AIAGR AITYG AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ATUGU AUFTA AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BQCPF BROTX BRXPI BY8 CS3 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRSTM DU5 EBD EBS EJD EMB EMOBN F00 F01 F04 F5P FEDTE G-S G.N G8K GNP GODZA H.T H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ H~9 IH2 IX1 J0M JPC KQQ L7B LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M56 MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MVM MXFUL MXSTM N04 N05 N9A NEJ NF~ NNB O66 O9- OHT OIG P2P P2W P2X P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO ROL RWI RWR RX1 RYL S10 SAMSI SUPJJ SV3 TN5 TWZ UB1 UPT V2E V8K VQP W8V W99 WBKPD WH7 WIB WIH WIK WJL WNSPC WOHZO WQJ WRC WXSBR WYB WYISQ X7M XG1 XJT XOL XPP XSW XV2 Y6R YQT YZZ ZGI ZXP ZZTAW ~IA ~WT ACSMX ACXME AFDAS AFMIJ AGHSJ CGR CUY CVF ECM EIF NPM XFK ZA5 AAYXX CITATION 7TK 7U7 8FD C1K FR3 K9. P64 RC3 7X8 |
ID | FETCH-LOGICAL-c4190-e2275fb4b93966d16d4dc37faa1ffbcbcde18d16c65d321e4e20f6d1168a43df3 |
IEDL.DBID | DR2 |
ISSN | 0021-9541 |
IngestDate | Thu Aug 15 23:48:29 EDT 2024 Fri Sep 13 09:58:44 EDT 2024 Fri Aug 23 01:57:05 EDT 2024 Thu May 23 23:47:49 EDT 2024 Sat Aug 24 00:54:45 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Keywords | skeletal muscle regeneration muscle satellite |
Language | English |
License | 2018 Wiley Periodicals, Inc. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c4190-e2275fb4b93966d16d4dc37faa1ffbcbcde18d16c65d321e4e20f6d1168a43df3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0003-4051-5108 |
PMID | 30070693 |
PQID | 2135599819 |
PQPubID | 1006363 |
PageCount | 10 |
ParticipantIDs | proquest_miscellaneous_2082092760 proquest_journals_2135599819 crossref_primary_10_1002_jcp_27040 pubmed_primary_30070693 wiley_primary_10_1002_jcp_27040_JCP27040 |
PublicationCentury | 2000 |
PublicationDate | February 2019 |
PublicationDateYYYYMMDD | 2019-02-01 |
PublicationDate_xml | – month: 02 year: 2019 text: February 2019 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States – name: Hoboken |
PublicationTitle | Journal of cellular physiology |
PublicationTitleAlternate | J Cell Physiol |
PublicationYear | 2019 |
Publisher | Wiley Subscription Services, Inc |
Publisher_xml | – name: Wiley Subscription Services, Inc |
References | e_1_2_7_1_10_1 e_1_2_7_1_11_1 e_1_2_7_1_12_1 e_1_2_7_1_13_1 e_1_2_7_1_30_1 e_1_2_7_1_5_1 e_1_2_7_1_29_1 e_1_2_7_1_6_1 e_1_2_7_1_7_1 e_1_2_7_1_8_1 e_1_2_7_1_25_1 e_1_2_7_1_2_1 e_1_2_7_1_26_1 e_1_2_7_1_3_1 e_1_2_7_1_27_1 e_1_2_7_1_4_1 e_1_2_7_1_28_1 e_1_2_7_1_21_1 e_1_2_7_1_22_1 e_1_2_7_1_23_1 e_1_2_7_1_24_1 e_1_2_7_1_9_1 e_1_2_7_1_20_1 e_1_2_7_1_18_1 e_1_2_7_1_19_1 e_1_2_7_1_14_1 e_1_2_7_1_15_1 e_1_2_7_1_16_1 e_1_2_7_1_17_1 |
References_xml | – ident: e_1_2_7_1_7_1 doi: 10.1016/j.cell.2005.05.010 – ident: e_1_2_7_1_21_1 doi: 10.1038/srep38371 – ident: e_1_2_7_1_22_1 doi: 10.1007/BF02634119 – ident: e_1_2_7_1_8_1 doi: 10.1126/science.1087573 – ident: e_1_2_7_1_12_1 doi: 10.1242/dev.067165 – ident: e_1_2_7_1_9_1 doi: 10.1523/JNEUROSCI.09-08-02678.1989 – ident: e_1_2_7_1_3_1 doi: 10.1073/pnas.0611732104 – ident: e_1_2_7_1_4_1 doi: 10.1002/stem.773 – ident: e_1_2_7_1_19_1 doi: 10.1002/stem.775 – ident: e_1_2_7_1_29_1 doi: 10.1371/journal.pone.0138517 – ident: e_1_2_7_1_5_1 doi: 10.1152/physrev.00019.2003 – ident: e_1_2_7_1_14_1 doi: 10.1016/j.stemcr.2017.12.013 – ident: e_1_2_7_1_11_1 doi: 10.3389/fphys.2013.00317 – ident: e_1_2_7_1_28_1 doi: 10.1113/jphysiol.2007.148338 – ident: e_1_2_7_1_27_1 doi: 10.1016/j.stem.2015.11.005 – ident: e_1_2_7_1_18_1 doi: 10.1074/jbc.M115.653477 – ident: e_1_2_7_1_30_1 doi: 10.1016/j.celrep.2015.08.083 – ident: e_1_2_7_1_24_1 doi: 10.1007/978-1-59745-060-7_19 – ident: e_1_2_7_1_16_1 doi: 10.1038/ncomms11624 – ident: e_1_2_7_1_13_1 doi: 10.1093/hmg/ddh190 – ident: e_1_2_7_1_26_1 doi: 10.1128/MCB.01408-13 – ident: e_1_2_7_1_17_1 doi: 10.1083/jcb.9.2.493 – ident: e_1_2_7_1_25_1 doi: 10.1016/j.bbrc.2006.01.037 – ident: e_1_2_7_1_20_1 doi: 10.1242/dev.112557 – ident: e_1_2_7_1_2_1 doi: 10.1002/(SICI)1097-4598(199612)19:12<1549::AID-MUS4>3.0.CO;2-A – ident: e_1_2_7_1_6_1 doi: 10.1038/nrm3591 – ident: e_1_2_7_1_15_1 doi: 10.1006/bbrc.1997.6943 – ident: e_1_2_7_1_10_1 doi: 10.1016/j.yexcr.2004.02.018 – ident: e_1_2_7_1_23_1 doi: 10.1096/fj.201500153 |
SSID | ssj0009933 |
Score | 2.3779707 |
Snippet | Nuclear factor erythroid 2–related factor 2 (Nrf2) is a master regulator for the induction of antioxidative genes and plays roles in diverse cellular... Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator for the induction of antioxidative genes and plays roles in diverse cellular... |
SourceID | proquest crossref pubmed wiley |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 1689 |
SubjectTerms | Animals Apoptosis Basal lamina Basement Membrane - metabolism Cell culture Cell Culture Techniques Cell Proliferation Cell Survival Cells, Cultured Collagen - metabolism Dependence Drug Combinations Fluorescence Laminin - metabolism Mice Mice, Inbred mdx Mice, Knockout Muscle Development muscle satellite Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles NF-E2-Related Factor 2 - deficiency NF-E2-Related Factor 2 - genetics Oxidative Stress Phenotypes Proteoglycans - metabolism Reactive Oxygen Species - metabolism Reagents Regeneration Rodents Satellite Cells, Skeletal Muscle - metabolism Satellite Cells, Skeletal Muscle - pathology Signal Transduction skeletal muscle Stem cell transplantation Stem cells Survival |
Title | Implication of basal lamina dependency in survival of Nrf2‐null muscle stem cells via an antioxidative‐independent mechanism |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjcp.27040 https://www.ncbi.nlm.nih.gov/pubmed/30070693 https://www.proquest.com/docview/2135599819/abstract/ https://search.proquest.com/docview/2082092760 |
Volume | 234 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB5CoNBLH0kf26ZFLaX04s3qYa1NTyE0pDmEUhrIoWD0BKesNsTr0s0pPyG_sb-kI3ntJSmBUvDB2GPJlmakb-TRNwDvDPO-MHqSWclEJqSbZAV1aFeF9XlMa5yrxPZ5LA9PxNFpfroBH_u9MB0_xLDgFi0jjdfRwJVudtekoWfmfMymqIM4_kYivQiIvq6po8pVGvkUgpAL2rMKTdju8OTNuegvgHkTr6YJ5-AhfO9ftYsz-TFuF3psLm-xOP7ntzyCBysgSvY6zXkMGy5swfZeQCd8tiTvSQoNTWvuW3Cvy1i53Iarz-sIdDL3BCdBLAS1qg6K9Al1zZLUgTQtjkKox1Hs-MKz31fXAf1dMmsbrJBEAmkSfxs05GetiAp4YKm_apuoyFG6HjL0LsjMxR3KdTN7AicHn77tH2arJA6ZEXGbumNsmnstdMnRs7JUWmENn3qlqPfaaGMdLfCykbnljDrh2MSjHJWFEtx6_hQ2wzy450C4jxLGJSc2JstxTJeyKKlWkSRajOBt353VecfVUXWszKzCFq5SC49gp-_oamWuTcUoj8xriI5G8Ga4jYYWm0EFN29RJoKlkk0lFvGsU5ChFh5Zk2TJR_AhdfPd1VdH-1_SyYt_F30J9xGmlV2s-A5sLi5a9wqh0EK_Tjr_B9R2B28 |
link.rule.ids | 315,786,790,1382,27957,27958,46329,46753 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1fa9RAEB9qRfSl1dbas1VXEfEl19s_ySXgSymWa62HSAt9kbC72YUot1eai3g-9SP0M_aTOLu55KgiiJCHkEx2N7sz2d9sZn8D8Foza1OtBlGRMBGJxAyilBq0q7SwsU9rHMvA9jlORmfi-Dw-X4F37V6Yhh-iW3DzlhG-197A_YL03pI19Ku-6LMhKuEduIvmHgeH6vOSPCpbJJIPQQixoC2v0IDtdY_eno3-gJi3EWuYcg7X4Uvb2CbS5Fu_nqm-_vkbj-P_vs1DWFtgUbLfKM8jWDFuAzb3Hfrhkzl5Q0J0aFh234B7TdLK-SZcHS2D0MnUEpwHsRBUrNJJ0ubU1XNSOlLV-CFCVfZi40vLbq6uHbaHTOoKKySeQ5r4PwcV-V5KIh0eWOqPsghs5Chddkl6Z2Ri_Cblspo8hrPD96cHo2iRxyHSwu9UN4wNY6uEyjg6VwVNClFoPrRSUmuVVrowNMXLOokLzqgRhg0sytEklYIXlm_Bqps6sw2EWy-hTfBjfb4cw1SWpBlV0vNEix68asczv2joOvKGmJnl2MN56OEe7LYjnS8stsoZ5Z58DQFSD152t9HWfDdIZ6Y1yni8lLFhgkU8aTSkq4V74qQk4z14G8b579XnxwefwsnTfxd9AfdHpx9P8pOj8YcdeICoLWtCx3dhdXZZm2eIjGbqeTCAX0cYC5E |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9RAFD7UiuKLl9bqatVRRHzJdueS2YQ-ldalrbIUsdAHISRzgSg7uzQbcX3qT-hv7C_pmckmSxVBhDyE5GQmmfnOzDmTM98BeKuYtYkqBpGWTERCmkGUUIN6lWgb-7TGcR7YPsfy8FQcn8Vna7Db7oVp-CG6BTevGWG89go-03ZnRRr6Tc36bIgYvAW3heTMQ_rg84o7Kl3mkQ8xCLGgLa3QgO10j96cjP6wMG8arGHGGT2Ar-27NoEm3_v1vOirX7_ROP7nxzyE-0tLlOw10HkEa8ZtwOaeQy98siDvSIgNDYvuG3CnSVm52ISLo1UIOplagrMgFoKwKl1O2oy6akFKR6oahyEEshcbn1t2dXHp0OElk7rCColnkCb-v0FFfpQ5yR0eWOrPUgcucpQuuxS9czIxfotyWU0ew-now5f9w2iZxSFSwu9TN4wNY1uIIuXoWmkqtdCKD22eU2sLVShtaIKXlYw1Z9QIwwYW5ahMcsG15Vuw7qbOPAXCrZdQJnixPluOYUUqk5QWuWeJFj1403ZnNmvIOrKGlpll2MJZaOEebLcdnS31tcoY5Z56Dc2jHrzubqOm-WbInZnWKOOtpZQNJRbxpAFIVwv3tEky5T14H7r579Vnx_sn4eTZv4u-grsnB6Ps09H443O4hyZb2sSNb8P6_Lw2L9AsmhcvA_yvASj7CkA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Implication+of+basal+lamina+dependency+in+survival+of+Nrf2-null+muscle+stem+cells+via+an+antioxidative-independent+mechanism&rft.jtitle=Journal+of+cellular+physiology&rft.au=Takemoto%2C+Yusei&rft.au=Inaba%2C+Shoya&rft.au=Zhang%2C+Lidan&rft.au=Tsujikawa%2C+Kazutake&rft.date=2019-02-01&rft.eissn=1097-4652&rft.volume=234&rft.issue=2&rft.spage=1689&rft.epage=1698&rft_id=info:doi/10.1002%2Fjcp.27040&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9541&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9541&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9541&client=summon |