Fibroblasts and mesenchymal stem cells: Two sides of the same coin?

• Published in: Journal of cellular physiology Vol. 233; no. 12; pp. 9099 - 9109
• Main Authors: Soundararajan, Mathangi, Kannan, Suresh
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2018
• Subjects: Analogies; Cell proliferation; Cell surface; cell surface markers; Deoxyribonucleic acid; DNA; DNA methylation; Embryo cells; Embryos; Ethical standards; Fibroblasts; Gene expression; Immunomodulation; Mesenchymal stem cells; mesenchymal stem/stromal cells (MSCs); Mesenchyme; Stem cells; Stromal cells; Surface markers; immunomodulation; fibroblasts; mesenchymal stem/stromal cells (MSCs); gene expression; cell surface markers

Mesenchymal stem/stromal cells (MSCs) have gained considerable popularity owing to the vast possibilities and lack of ethical constraints and risks normally associated with other stem cells, such as embryonic stem cells. However, they are morphologically indistinguishable from fibroblasts. This revi...