Vitamin K antagonist reversal strategies: Systematic review and network meta‐analysis from the AABB

• Published in: Transfusion (Philadelphia, Pa.) Vol. 62; no. 8; pp. 1652 - 1661
• Main Authors: Pagano, Monica B., Foroutan, Farid, Goel, Ruchika, Allen, Elizabeth S., Cushing, Melissa M., Garcia, David A., Hopkins, Courtney K., Klein, Kimberly, Raval, Jay S., Cohn, Claudia S.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2022; Wiley Subscription Services, Inc
• Subjects: Anticoagulants; Anticoagulants - adverse effects; anticoagulation; Bleeding; Blood Coagulation Factors - therapeutic use; Factor IX; Factor X; Fibrinolytic Agents; Hemorrhage - chemically induced; Hemorrhage - drug therapy; Humans; International Normalized Ratio; Meta-analysis; Plasma; Prothrombin; prothrombin complex concentrate; Retrospective Studies; Transfusion; Vitamin K; Vitamin K - therapeutic use; Warfarin; anticoagulation; prothrombin complex concentrate; warfarin

Background Anticoagulation requires urgent reversal in cases of life‐threatening bleeding or invasive procedures. Study Design and Methods Network meta‐analysis for comparing the safety and efficacy of warfarin reversal strategies including plasma and prothrombin complex concentrates (PCCs). Results...