Circulating microRNAs as diagnostic and therapeutic biomarkers in gastric and esophageal cancers

Gastric and esophageal cancers are as main cancers of the gastrointestinal (GI) tract, which are associated with poor diagnosis and survival. Several efforts were made in the past few decades to finding effective therapeutic approaches, but these approaches had several problems. Finding new biomarke...

Full description

Saved in:
Bibliographic Details
Published inJournal of cellular physiology Vol. 233; no. 11; pp. 8538 - 8550
Main Authors Jamali, Leila, Tofigh, Roghayeh, Tutunchi, Sara, Panahi, Ghodratollah, Borhani, Fatemeh, Akhavan, Saeedeh, Nourmohammadi, Parisa, Ghaderian, Sayyed M.H., Rasouli, Milad, Mirzaei, Hamed
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.11.2018
Subjects
Biomarkers
Cancer
Deregulation
Diagnosis
Diagnostic systems
esophagal cancer
Esophageal cancer
Esophagus
Gastric cancer
gastric carcinogenesis
Gastrointestinal tract
Gene expression
mechanisms
microRNA (miRNA)
MicroRNAs
miRNA
Ribonucleic acid
RNA
Tumors
gastric carcinogenesis
microRNA (miRNA)
mechanisms
esophagal cancer
Online AccessGet full text

Cover

Abstract Gastric and esophageal cancers are as main cancers of the gastrointestinal (GI) tract, which are associated with poor diagnosis and survival. Several efforts were made in the past few decades to finding effective therapeutic approaches, but these approaches had several problems. Finding new biomarkers is a critical step in finding new approaches for the treatment of these cancers. Finding new biomarkers that cover various aspects of the diseases could provide a choice of suitable therapies and better monitoring of patients with these cancers. Among several biomarkers tissue specific and circulating microRNAs (miRNAs) have emerged as powerful candidates in the diagnosis of gastric and esophageal cancers. MiRNAs are small noncoding single‐stranded RNA molecules that are found in the blood and regulate gene expression. These have numerous characteristics that make them suitable for being used as ideal biomarkers in cancer diagnosis. Research has indicated that the level and profile of miRNA in serum and plasma are very high. They are potentially noninvasive and sensitive enough to detect tumors in their primary stages of infection. Multiple lines of evidence indicate that the presence, absence, or deregulation of several circulating miRNAs (i.e., let‐7a, miR‐21, miR‐93, miR‐192a, miR‐18a, and miR‐10b for gastric cancer, and miR‐21, miR‐375, miR‐25‐3p, miR‐151a‐3p, and miR‐100‐3p for esophageal cancer) are associated with initiation and progression of gastric and esophageal cancers. The aim of this review is to highlight the recent advances in the roles of miRNAs in diagnosis and treatment of gastric and esophageal cancers. The aims of this review is to highlight the recent advances in the roles of microRNAs in diagnosis and treatment of gastric and esophageal cancers.
AbstractList Gastric and esophageal cancers are as main cancers of the gastrointestinal (GI) tract, which are associated with poor diagnosis and survival. Several efforts were made in the past few decades to finding effective therapeutic approaches, but these approaches had several problems. Finding new biomarkers is a critical step in finding new approaches for the treatment of these cancers. Finding new biomarkers that cover various aspects of the diseases could provide a choice of suitable therapies and better monitoring of patients with these cancers. Among several biomarkers tissue specific and circulating microRNAs (miRNAs) have emerged as powerful candidates in the diagnosis of gastric and esophageal cancers. MiRNAs are small noncoding single‐stranded RNA molecules that are found in the blood and regulate gene expression. These have numerous characteristics that make them suitable for being used as ideal biomarkers in cancer diagnosis. Research has indicated that the level and profile of miRNA in serum and plasma are very high. They are potentially noninvasive and sensitive enough to detect tumors in their primary stages of infection. Multiple lines of evidence indicate that the presence, absence, or deregulation of several circulating miRNAs (i.e., let‐7a, miR‐21, miR‐93, miR‐192a, miR‐18a, and miR‐10b for gastric cancer, and miR‐21, miR‐375, miR‐25‐3p, miR‐151a‐3p, and miR‐100‐3p for esophageal cancer) are associated with initiation and progression of gastric and esophageal cancers. The aim of this review is to highlight the recent advances in the roles of miRNAs in diagnosis and treatment of gastric and esophageal cancers.
Gastric and esophageal cancers are as main cancers of the gastrointestinal (GI) tract, which are associated with poor diagnosis and survival. Several efforts were made in the past few decades to finding effective therapeutic approaches, but these approaches had several problems. Finding new biomarkers is a critical step in finding new approaches for the treatment of these cancers. Finding new biomarkers that cover various aspects of the diseases could provide a choice of suitable therapies and better monitoring of patients with these cancers. Among several biomarkers tissue specific and circulating microRNAs (miRNAs) have emerged as powerful candidates in the diagnosis of gastric and esophageal cancers. MiRNAs are small noncoding single‐stranded RNA molecules that are found in the blood and regulate gene expression. These have numerous characteristics that make them suitable for being used as ideal biomarkers in cancer diagnosis. Research has indicated that the level and profile of miRNA in serum and plasma are very high. They are potentially noninvasive and sensitive enough to detect tumors in their primary stages of infection. Multiple lines of evidence indicate that the presence, absence, or deregulation of several circulating miRNAs (i.e., let‐7a, miR‐21, miR‐93, miR‐192a, miR‐18a, and miR‐10b for gastric cancer, and miR‐21, miR‐375, miR‐25‐3p, miR‐151a‐3p, and miR‐100‐3p for esophageal cancer) are associated with initiation and progression of gastric and esophageal cancers. The aim of this review is to highlight the recent advances in the roles of miRNAs in diagnosis and treatment of gastric and esophageal cancers. The aims of this review is to highlight the recent advances in the roles of microRNAs in diagnosis and treatment of gastric and esophageal cancers.
Gastric and esophageal cancers are as main cancers of the gastrointestinal (GI) tract, which are associated with poor diagnosis and survival. Several efforts were made in the past few decades to finding effective therapeutic approaches, but these approaches had several problems. Finding new biomarkers is a critical step in finding new approaches for the treatment of these cancers. Finding new biomarkers that cover various aspects of the diseases could provide a choice of suitable therapies and better monitoring of patients with these cancers. Among several biomarkers tissue specific and circulating microRNAs (miRNAs) have emerged as powerful candidates in the diagnosis of gastric and esophageal cancers. MiRNAs are small noncoding single-stranded RNA molecules that are found in the blood and regulate gene expression. These have numerous characteristics that make them suitable for being used as ideal biomarkers in cancer diagnosis. Research has indicated that the level and profile of miRNA in serum and plasma are very high. They are potentially noninvasive and sensitive enough to detect tumors in their primary stages of infection. Multiple lines of evidence indicate that the presence, absence, or deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer) are associated with initiation and progression of gastric and esophageal cancers. The aim of this review is to highlight the recent advances in the roles of miRNAs in diagnosis and treatment of gastric and esophageal cancers.Gastric and esophageal cancers are as main cancers of the gastrointestinal (GI) tract, which are associated with poor diagnosis and survival. Several efforts were made in the past few decades to finding effective therapeutic approaches, but these approaches had several problems. Finding new biomarkers is a critical step in finding new approaches for the treatment of these cancers. Finding new biomarkers that cover various aspects of the diseases could provide a choice of suitable therapies and better monitoring of patients with these cancers. Among several biomarkers tissue specific and circulating microRNAs (miRNAs) have emerged as powerful candidates in the diagnosis of gastric and esophageal cancers. MiRNAs are small noncoding single-stranded RNA molecules that are found in the blood and regulate gene expression. These have numerous characteristics that make them suitable for being used as ideal biomarkers in cancer diagnosis. Research has indicated that the level and profile of miRNA in serum and plasma are very high. They are potentially noninvasive and sensitive enough to detect tumors in their primary stages of infection. Multiple lines of evidence indicate that the presence, absence, or deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer) are associated with initiation and progression of gastric and esophageal cancers. The aim of this review is to highlight the recent advances in the roles of miRNAs in diagnosis and treatment of gastric and esophageal cancers.
Author Jamali, Leila
Panahi, Ghodratollah
Borhani, Fatemeh
Mirzaei, Hamed
Tutunchi, Sara
Rasouli, Milad
Tofigh, Roghayeh
Nourmohammadi, Parisa
Akhavan, Saeedeh
Ghaderian, Sayyed M.H.
Author_xml – sequence: 1
  givenname: Leila
  surname: Jamali
  fullname: Jamali, Leila
  organization: School of Medicine, Shahid Beheshti University of Medical Sciences
– sequence: 2
  givenname: Roghayeh
  surname: Tofigh
  fullname: Tofigh, Roghayeh
  organization: Tabriz University
– sequence: 3
  givenname: Sara
  surname: Tutunchi
  fullname: Tutunchi, Sara
  organization: Shahid Sadoughi University of Medical Sciences
– sequence: 4
  givenname: Ghodratollah
  surname: Panahi
  fullname: Panahi, Ghodratollah
  organization: Faculty of Medicine, Tehran University of Medical Sciences
– sequence: 5
  givenname: Fatemeh
  surname: Borhani
  fullname: Borhani, Fatemeh
  organization: Faculty of Medicine, Shahid Beheshti University of Medical Sciences
– sequence: 6
  givenname: Saeedeh
  surname: Akhavan
  fullname: Akhavan, Saeedeh
  organization: School of Basic Sciences, Science and Research Branch, Islamic Azad University
– sequence: 7
  givenname: Parisa
  surname: Nourmohammadi
  fullname: Nourmohammadi, Parisa
  organization: Shahid Sadoughi University of Medical Sciences
– sequence: 8
  givenname: Sayyed M.H.
  surname: Ghaderian
  fullname: Ghaderian, Sayyed M.H.
  email: SGhaderian@yahoo.co.uk, s.ghaderian@sbmu.ac.ir
  organization: Shahid Beheshti University of Medical Sciences
– sequence: 9
  givenname: Milad
  surname: Rasouli
  fullname: Rasouli, Milad
  organization: Faculty of Medical Sciences, Tarbiat Modares University
– sequence: 10
  givenname: Hamed
  orcidid: 0000-0002-9399-8281
  surname: Mirzaei
  fullname: Mirzaei, Hamed
  email: h.mirzaei2002@gmail.com
  organization: Mashhad University of Medical Sciences
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29923196$$D View this record in MEDLINE/PubMed
BookMark eNp90UtP3DAQB3ALgWB5HPgCKBKX9hDw2M7DR7SiD4RoheBsHGeyeMnawU5U8e1rulsOSHCyRv7NyP7PPtl23iEhx0DPgFJ2vjTDGSvrgm6RGVBZ5aIs2DaZpTvIZSFgj-zHuKSUSsn5LtljUjIOspyRh7kNZur1aN0iW1kT_O3NRcx0zFqrF87H0ZpMuzYbHzHoAafXurF-pcMThphZly10HMNGYfTDo16g7jOjnUnikOx0uo94tDkPyP23y7v5j_z61_ef84vr3AiQNK8azrq6rDpRadFpMG0DAqCmtWm6gokChEgVUk7busbKoCnbjkLLNEeJhh-QL-u5Q_DPE8ZRrWw02PfaoZ-iYrSoBJdcQqKn7-jST8Gl1ykGIOqC8UIkdbJRU7PCVg3Bpk-_qP_ZJfB1DVJoMQbs3ghQ9boXlfai_u0l2fN31tgxhe7dGLTtP-v4Y3t8-Xi0upr_Xnf8BeRRndU
CitedBy_id crossref_primary_10_3892_ol_2021_13077
crossref_primary_10_1038_s41598_022_13430_8
crossref_primary_10_1002_ijc_31947
crossref_primary_10_1002_jcb_28068
crossref_primary_10_1007_s10620_020_06740_2
crossref_primary_10_1002_jcp_27806
crossref_primary_10_1177_15330338211038492
crossref_primary_10_1002_jcb_28503
crossref_primary_10_1080_15384101_2020_1809914
crossref_primary_10_2174_1566524021666210526162917
crossref_primary_10_1080_07391102_2024_2328744
crossref_primary_10_1080_17474124_2020_1715211
crossref_primary_10_1111_jnc_14616
crossref_primary_10_1002_rmv_2014
crossref_primary_10_1002_cam4_5826
crossref_primary_10_2147_CMAR_S259077
crossref_primary_10_2147_CMAR_S494747
crossref_primary_10_1002_cam4_2792
crossref_primary_10_1155_2021_9951010
crossref_primary_10_1371_journal_pone_0231116
crossref_primary_10_3389_fnagi_2020_00010
crossref_primary_10_1007_s12012_024_09914_w
crossref_primary_10_3390_bioengineering10080892
crossref_primary_10_3892_ijo_2019_4759
crossref_primary_10_1007_s12032_023_01980_4
crossref_primary_10_1186_s12935_020_01192_0
crossref_primary_10_1007_s12602_021_09770_y
crossref_primary_10_3390_diagnostics13010118
crossref_primary_10_3389_fonc_2021_626036
crossref_primary_10_1002_jcp_27776
crossref_primary_10_1016_j_prp_2023_154529
crossref_primary_10_2174_1566524020666200712182137
crossref_primary_10_15171_apb_2019_073
crossref_primary_10_18632_aging_104074
crossref_primary_10_1002_jcb_29130
crossref_primary_10_3892_ol_2019_10636
crossref_primary_10_3389_fmicb_2025_1558482
crossref_primary_10_1002_jcb_29018
crossref_primary_10_3389_fcell_2019_00253
crossref_primary_10_1186_s11658_019_0178_5
crossref_primary_10_1002_jcp_27486
crossref_primary_10_1111_bjd_19254
crossref_primary_10_3233_CBM_190384
crossref_primary_10_1002_jcb_28214
crossref_primary_10_1002_ptr_6572
crossref_primary_10_1002_jcp_27519
crossref_primary_10_1002_jcb_28179
crossref_primary_10_3389_fnins_2018_00625
crossref_primary_10_1111_fcp_12521
crossref_primary_10_1002_jcp_27755
crossref_primary_10_1016_j_prp_2023_154508
crossref_primary_10_1515_med_2022_0625
crossref_primary_10_1016_j_intimp_2020_107145
crossref_primary_10_1016_j_prp_2019_01_035
crossref_primary_10_1159_000508019
crossref_primary_10_2147_OTT_S238665
crossref_primary_10_1017_S0031182019001690
crossref_primary_10_1186_s12935_020_01740_8
crossref_primary_10_2147_OTT_S275688
crossref_primary_10_3390_cancers13184500
crossref_primary_10_1016_j_heliyon_2024_e29169
crossref_primary_10_1177_09603271231155093
crossref_primary_10_1007_s12672_024_01120_y
crossref_primary_10_1007_s11064_019_02900_7
crossref_primary_10_1016_j_mcp_2020_101601
crossref_primary_10_2217_epi_2020_0093
crossref_primary_10_3892_ijmm_2025_5508
crossref_primary_10_1186_s12967_019_2058_1
crossref_primary_10_1016_j_heliyon_2023_e14515
crossref_primary_10_1186_s12885_022_10124_2
crossref_primary_10_2174_1381612825666190829154934
crossref_primary_10_1016_j_clinbiochem_2024_110767
crossref_primary_10_1002_med_21646
crossref_primary_10_3389_fnins_2024_1385675
crossref_primary_10_1177_1533033820920967
crossref_primary_10_1186_s12935_021_02132_2
crossref_primary_10_1016_j_ejphar_2022_174957
crossref_primary_10_1016_j_prp_2019_04_011
crossref_primary_10_1016_j_intimp_2020_106828
crossref_primary_10_1016_j_prp_2022_154196
crossref_primary_10_2174_1386207323666200901101955
crossref_primary_10_1002_jcb_27984
crossref_primary_10_1016_j_intimp_2020_106798
crossref_primary_10_1002_jcb_28433
crossref_primary_10_1016_j_bspc_2022_103545
crossref_primary_10_1002_jcb_28834
crossref_primary_10_3389_fonc_2020_00031
crossref_primary_10_1111_hiv_12822
crossref_primary_10_1155_2022_8034038
crossref_primary_10_1186_s12935_021_01826_x
crossref_primary_10_1016_j_talanta_2024_125675
crossref_primary_10_1002_jcb_29053
crossref_primary_10_3389_fgene_2019_00626
crossref_primary_10_3389_fcell_2021_716462
crossref_primary_10_1002_jcp_27270
crossref_primary_10_3934_mbe_2021345
crossref_primary_10_1016_j_lfs_2020_117741
crossref_primary_10_2147_OTT_S245663
crossref_primary_10_1016_j_prp_2021_153701
crossref_primary_10_2174_1574888X17666220422094150
crossref_primary_10_1111_hel_12813
crossref_primary_10_1007_s13258_021_01060_9
crossref_primary_10_2174_1566524019666191001113511
crossref_primary_10_2174_0929867326666190911114842
crossref_primary_10_1097_MEG_0000000000001815
crossref_primary_10_3390_ijms241411870
crossref_primary_10_1016_j_prp_2019_152636
crossref_primary_10_3892_mmr_2021_12428
crossref_primary_10_1002_jcp_27286
crossref_primary_10_1002_jcb_28892
crossref_primary_10_29252_jcbr_3_3_5
crossref_primary_10_1002_jcb_28499
crossref_primary_10_3389_fonc_2020_564785
crossref_primary_10_1002_jcb_28419
crossref_primary_10_1177_1533033820945302
crossref_primary_10_1186_s12935_021_01814_1
crossref_primary_10_3892_etm_2019_7940
crossref_primary_10_1002_jcp_27956
Cites_doi 10.1016/j.ygyno.2008.08.036
10.1111/j.1442-2050.2012.01389.x
10.3727/096504017X15035025554553
10.2174/1381612820666140128213117
10.1186/s12885-015-1031-5
10.1073/pnas.0804549105
10.1016/j.prp.2017.06.006
10.3892/ijo.2016.3453
10.1186/s40478-014-0173-z
10.2174/1389450116666150325231555
10.1373/clinchem.2010.147553
10.1158/1055-9965.EPI-16-0607
10.1158/0008-5472.CAN-05-1783
10.12659/MSM.897663
10.1007/s10620-017-4831-4
10.1007/s12032-014-0164-8
10.1093/carcin/bgq240
10.3760/cma.j.issn.0366-6999.20122918
10.1007/s12094-017-1668-4
10.3233/CBM-2011-0231
10.3390/s120303359
10.1007/s11033-012-2267-7
10.1007/s10620-011-1981-7
10.1002/ijc.30224
10.1093/nar/gki200
10.1016/j.ejphar.2016.09.025
10.1002/jcb.26271
10.1002/jcp.25799
10.1016/j.neulet.2016.10.034
10.1002/jcb.26300
10.1002/jcp.25793
10.1002/jcp.26070
10.1089/dna.2017.3922
10.1186/1756-9966-33-10
10.1186/s40064-016-2119-3
10.1007/978-3-319-01580-4_3
10.4103/0973-1482.175428
10.1186/1472-6750-7-1
10.1093/nar/gkr254
10.1128/MCB.01977-07
10.1016/j.biopha.2017.08.144
10.1007/s11033-010-0480-9
10.1111/his.12401
10.3390/s120709349
10.1016/j.bios.2006.01.006
10.1016/j.canlet.2015.07.015
10.1002/jcp.25801
10.1007/s13277-014-2516-6
10.1038/sj.bjc.6605608
10.1073/pnas.0510565103
10.1016/j.tibs.2016.08.004
10.3892/or.2017.5758
10.1038/nature02871
10.1007/s12038-012-9192-8
10.1016/j.bbrc.2016.01.042
10.1186/s13000-016-0536-9
10.2174/0929867323666160818093854
10.1016/j.ejca.2015.10.009
10.3892/mmr.2017.6979
10.1007/s13277-015-4019-5
10.1093/carcin/bgs259
10.1371/journal.pone.0033987
10.1186/1756-9966-31-38
10.2174/1381612822666151112151924
10.1111/j.1365-2141.2008.07077.x
10.3892/or.2017.5745
10.3748/wjg.v20.i19.5694
10.3892/ol.2017.6558
10.2147/OTT.S139443
10.1007/s10620-013-2970-9
10.1002/cam4.973
10.1038/bjc.2011.198
10.1073/pnas.0813371106
10.1002/jcp.26379
10.1016/j.gene.2012.12.031
10.1002/ijc.25516
10.3892/or.2014.3327
10.1002/ijc.25284
10.1007/s11033-011-0854-7
10.7150/thno.10305
10.2353/ajpath.2009.080718
10.1038/sj.onc.1210425
10.3233/CBM-170310
10.3892/or.2014.3004
10.1002/jcb.26497
10.1007/s00432-016-2316-z
10.1056/NEJMra035010
10.1186/1476-4598-5-24
10.2174/1381612822666160303110838
10.7314/APJCP.2013.14.12.7551
10.3892/mmr.2017.7758
10.1158/0008-5472.CAN-16-0359
10.1186/1479-5876-11-301
10.1002/jcb.26244
10.1155/2014/931083
10.18632/oncotarget.6499
10.1002/jcb.26130
10.1371/journal.pone.0115589
10.1002/jcp.25787
10.1002/jcb.26599
10.1016/j.jmoldx.2013.04.004
10.3233/CBM-150564
10.3727/096504017X14847395834985
10.1371/journal.pone.0073278
10.4103/0973-1482.153661
10.1038/onc.2008.256
10.1007/s00109-010-0617-2
10.2217/pgs-2018-0197
10.1038/onc.2012.506
10.1002/ijc.28757
10.1186/1476-4598-11-51
10.1002/jcb.26413
10.1016/j.biopha.2017.01.161
10.1038/bjc.2011.588
10.1016/j.canlet.2017.04.006
10.2174/1871520615666150716110657
10.1038/onc.2017.29
10.3748/wjg.v20.i22.6906
10.1155/2015/731479
10.3892/or.2012.1645
10.1002/jcb.26146
10.1016/j.ejca.2010.10.025
10.1186/s12943-015-0473-3
10.1016/bs.acc.2017.06.004
10.1042/CS20110207
10.1007/s10120-014-0363-1
10.1002/path.4030
10.1016/j.canlet.2017.11.007
10.1002/jcp.25738
10.1155/2015/435656
10.1007/s10620-014-3433-7
10.1002/ijc.25506
10.3892/ol.2013.1626
10.1002/jcp.25930
10.1371/journal.pone.0033608
10.1158/1078-0432.CCR-12-0701
10.3892/ol.2017.6777
10.1158/1078-0432.CCR-08-2545
10.1016/j.jgg.2015.09.010
10.1038/bjc.2014.485
10.1373/clinchem.2007.097972
10.1038/cgt.2016.52
10.1007/s10620-013-2854-z
10.1016/j.canlet.2011.10.034
10.3892/etm.2017.4798
10.1007/s00432-012-1244-9
10.1038/ncomms3544
ContentType Journal Article
Copyright 2018 Wiley Periodicals, Inc.
Copyright_xml – notice: 2018 Wiley Periodicals, Inc.
DBID AAYXX
CITATION
NPM
7TK
7U7
8FD
C1K
FR3
K9.
P64
RC3
7X8
DOI 10.1002/jcp.26850
DatabaseName CrossRef
PubMed
Neurosciences Abstracts
Toxicology Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
ProQuest Health & Medical Complete (Alumni)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
Genetics Abstracts
Technology Research Database
Toxicology Abstracts
ProQuest Health & Medical Complete (Alumni)
Engineering Research Database
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
MEDLINE - Academic
DatabaseTitleList Genetics Abstracts

PubMed
MEDLINE - Academic
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
Biology
EISSN 1097-4652
EndPage 8550
ExternalDocumentID 29923196
10_1002_jcp_26850
JCP26850
Genre reviewArticle
Journal Article
Review
GroupedDBID ---
-DZ
-~X
.3N
.55
.GA
.GJ
.Y3
05W
0R~
10A
1L6
1OB
1OC
1ZS
31~
33P
36B
3O-
3SF
3WU
4.4
4ZD
50Y
50Z
51W
51X
52M
52N
52O
52P
52S
52T
52U
52W
52X
53G
5GY
5RE
5VS
66C
702
7PT
8-0
8-1
8-3
8-4
8-5
85S
8UM
930
9M8
A03
AAESR
AAEVG
AAHHS
AAHQN
AAMNL
AANHP
AANLZ
AAONW
AASGY
AAXRX
AAYCA
AAZKR
ABCQN
ABCUV
ABDPE
ABEFU
ABEML
ABIJN
ABJNI
ABPPZ
ABPVW
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFO
ACGFS
ACNCT
ACPOU
ACPRK
ACRPL
ACSCC
ACXBN
ACXQS
ACYXJ
ADBBV
ADEOM
ADIZJ
ADKYN
ADMGS
ADNMO
ADOZA
ADXAS
ADZMN
ADZOD
AEEZP
AEGXH
AEIGN
AEIMD
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFFPM
AFGKR
AFPWT
AFRAH
AFWVQ
AFZJQ
AHBTC
AHMBA
AIAGR
AITYG
AIURR
AIWBW
AJBDE
AJXKR
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
ALVPJ
AMBMR
AMYDB
ATUGU
AUFTA
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMNLL
BMXJE
BNHUX
BQCPF
BROTX
BRXPI
BY8
CS3
D-E
D-F
DCZOG
DPXWK
DR1
DR2
DRFUL
DRSTM
DU5
EBD
EBS
EJD
EMB
EMOBN
F00
F01
F04
F5P
FEDTE
G-S
G.N
GNP
GODZA
H.T
H.X
HBH
HF~
HGLYW
HHY
HHZ
HVGLF
HZ~
H~9
IH2
IX1
J0M
JPC
KQQ
L7B
LATKE
LAW
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
M56
MEWTI
MK4
MRFUL
MRSTM
MSFUL
MSSTM
MVM
MXFUL
MXSTM
N04
N05
N9A
NEJ
NF~
NNB
O66
O9-
OHT
OIG
P2P
P2W
P2X
P4D
PALCI
PQQKQ
Q.N
Q11
QB0
QRW
R.K
RIWAO
ROL
RWI
RWR
RX1
RYL
S10
SAMSI
SUPJJ
SV3
TN5
TWZ
UB1
UPT
V2E
V8K
VQP
W8V
W99
WBKPD
WH7
WIB
WIH
WIK
WJL
WNSPC
WOHZO
WQJ
WRC
WXSBR
WYB
WYISQ
X7M
XG1
XJT
XOL
XPP
XSW
XV2
Y6R
YQT
YZZ
ZGI
ZXP
ZZTAW
~IA
~WT
AAYXX
ADXHL
AETEA
AEYWJ
AGHNM
AGQPQ
AGYGG
CITATION
NPM
7TK
7U7
8FD
AAMMB
AEFGJ
AGXDD
AIDQK
AIDYY
C1K
FR3
K9.
P64
RC3
7X8
ID FETCH-LOGICAL-c4190-7b32f867f47a4fa1cdb1411808cbf5245144180e030d88e7cec6df01d2a3e9ec3
IEDL.DBID DR2
ISSN 0021-9541
1097-4652
IngestDate Fri Jul 11 15:19:52 EDT 2025
Fri Jul 25 09:10:10 EDT 2025
Thu Apr 03 07:06:29 EDT 2025
Tue Jul 01 01:31:52 EDT 2025
Thu Apr 24 22:56:59 EDT 2025
Wed Jan 22 17:12:02 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 11
Keywords gastric carcinogenesis
microRNA (miRNA)
mechanisms
esophagal cancer
Language English
License 2018 Wiley Periodicals, Inc.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4190-7b32f867f47a4fa1cdb1411808cbf5245144180e030d88e7cec6df01d2a3e9ec3
Notes Ghaderian, Rasouli, and Mirzaei contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-9399-8281
PMID 29923196
PQID 2114852354
PQPubID 1006363
PageCount 13
ParticipantIDs proquest_miscellaneous_2057439391
proquest_journals_2114852354
pubmed_primary_29923196
crossref_primary_10_1002_jcp_26850
crossref_citationtrail_10_1002_jcp_26850
wiley_primary_10_1002_jcp_26850_JCP26850
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate November 2018
PublicationDateYYYYMMDD 2018-11-01
PublicationDate_xml – month: 11
  year: 2018
  text: November 2018
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Hoboken
PublicationTitle Journal of cellular physiology
PublicationTitleAlternate J Cell Physiol
PublicationYear 2018
Publisher Wiley Subscription Services, Inc
Publisher_xml – name: Wiley Subscription Services, Inc
References e_1_2_8_1_13_1
e_1_2_8_1_32_1
e_1_2_8_1_51_1
e_1_2_8_1_70_1
e_1_2_8_1_124_1
Song J. (e_1_2_8_1_110_1) 2014; 127
e_1_2_8_1_101_1
e_1_2_8_1_143_1
e_1_2_8_1_105_1
e_1_2_8_1_128_1
e_1_2_8_1_81_1
e_1_2_8_1_147_1
e_1_2_8_1_85_1
e_1_2_8_1_162_1
e_1_2_8_1_89_1
e_1_2_8_1_120_1
e_1_2_8_1_29_1
e_1_2_8_1_47_1
e_1_2_8_1_24_1
e_1_2_8_1_66_1
Xu G. (e_1_2_8_1_146_1) 2018; 41
e_1_2_8_1_20_1
e_1_2_8_1_109_1
Li S. (e_1_2_8_1_58_1) 2015; 8
e_1_2_8_1_112_1
e_1_2_8_1_135_1
e_1_2_8_1_3_1
Liao Z. (e_1_2_8_1_62_1) 2018; 17
Lang B. (e_1_2_8_1_50_1) 2018; 39
e_1_2_8_1_116_1
e_1_2_8_1_139_1
e_1_2_8_1_93_1
e_1_2_8_1_150_1
e_1_2_8_1_74_1
e_1_2_8_1_97_1
e_1_2_8_1_131_1
e_1_2_8_1_78_1
e_1_2_8_1_17_1
e_1_2_8_1_14_1
e_1_2_8_1_33_1
Li H. (e_1_2_8_1_55_1) 2017; 8
e_1_2_8_1_10_1
e_1_2_8_1_52_1
e_1_2_8_1_71_1
e_1_2_8_1_8_1
e_1_2_8_1_118_1
Komatsu S. (e_1_2_8_1_48_1) 2013; 33
e_1_2_8_1_102_1
e_1_2_8_1_121_1
e_1_2_8_1_144_1
e_1_2_8_1_106_1
e_1_2_8_1_82_1
e_1_2_8_1_125_1
e_1_2_8_1_148_1
e_1_2_8_1_167_1
Wang M. (e_1_2_8_1_138_1) 2012; 5
e_1_2_8_1_86_1
e_1_2_8_1_163_1
e_1_2_8_1_26_1
e_1_2_8_1_140_1
e_1_2_8_1_49_1
e_1_2_8_1_25_1
e_1_2_8_1_44_1
e_1_2_8_1_67_1
e_1_2_8_1_21_1
e_1_2_8_1_40_1
Weng W. (e_1_2_8_1_141_1) 2013; 33
e_1_2_8_1_129_1
e_1_2_8_1_113_1
e_1_2_8_1_159_1
e_1_2_8_1_90_1
e_1_2_8_1_132_1
e_1_2_8_1_117_1
e_1_2_8_1_155_1
e_1_2_8_1_4_1
e_1_2_8_1_136_1
Zhang K. (e_1_2_8_1_160_1) 2016; 6
e_1_2_8_1_151_1
e_1_2_8_1_75_1
e_1_2_8_1_98_1
Jin L. (e_1_2_8_1_41_1) 2016; 32
e_1_2_8_1_18_1
e_1_2_8_1_37_1
e_1_2_8_1_79_1
e_1_2_8_1_170_1
e_1_2_8_1_11_1
e_1_2_8_1_57_1
e_1_2_8_1_34_1
e_1_2_8_1_53_1
Mori Y. (e_1_2_8_1_94_1) 2009; 2
e_1_2_8_1_30_1
e_1_2_8_1_9_1
e_1_2_8_1_119_1
Li S. L. (e_1_2_8_1_59_1) 2017; 21
e_1_2_8_1_145_1
e_1_2_8_1_122_1
e_1_2_8_1_149_1
Zhang K. C. (e_1_2_8_1_161_1) 2015; 5
e_1_2_8_1_103_1
e_1_2_8_1_83_1
e_1_2_8_1_126_1
e_1_2_8_1_168_1
Zali H. (e_1_2_8_1_154_1) 2011; 2
e_1_2_8_1_87_1
e_1_2_8_1_164_1
Komatsu S. (e_1_2_8_1_46_1) 2016; 6
e_1_2_8_1_22_1
e_1_2_8_1_68_1
Li L. (e_1_2_8_1_56_1) 2017
e_1_2_8_1_45_1
e_1_2_8_1_64_1
Karimi Kurdistani Z. (e_1_2_8_1_43_1) 2015; 18
e_1_2_8_1_60_1
e_1_2_8_1_107_1
e_1_2_8_1_133_1
e_1_2_8_1_91_1
e_1_2_8_1_114_1
e_1_2_8_1_137_1
e_1_2_8_1_156_1
e_1_2_8_1_5_1
e_1_2_8_1_72_1
e_1_2_8_1_95_1
e_1_2_8_1_19_1
e_1_2_8_1_152_1
e_1_2_8_1_76_1
e_1_2_8_1_15_1
e_1_2_8_1_99_1
e_1_2_8_1_171_1
e_1_2_8_1_38_1
e_1_2_8_1_12_1
e_1_2_8_1_31_1
e_1_2_8_1_54_1
Hundt S. (e_1_2_8_1_35_1) 2007; 16
Zhang X. Y. (e_1_2_8_1_166_1) 2017; 21
e_1_2_8_1_100_1
e_1_2_8_1_123_1
e_1_2_8_1_169_1
e_1_2_8_1_80_1
e_1_2_8_1_127_1
e_1_2_8_1_165_1
e_1_2_8_1_104_1
He J. (e_1_2_8_1_27_1) 2017; 14
e_1_2_8_1_84_1
e_1_2_8_1_88_1
e_1_2_8_1_142_1
e_1_2_8_1_28_1
e_1_2_8_1_23_1
e_1_2_8_1_69_1
e_1_2_8_1_42_1
e_1_2_8_1_65_1
e_1_2_8_1_61_1
e_1_2_8_1_108_1
Lin C. (e_1_2_8_1_63_1) 2014; 7
e_1_2_8_1_2_1
e_1_2_8_1_134_1
Zhang J. (e_1_2_8_1_158_1) 2014; 7
e_1_2_8_1_111_1
e_1_2_8_1_6_1
e_1_2_8_1_92_1
e_1_2_8_1_115_1
e_1_2_8_1_157_1
e_1_2_8_1_73_1
e_1_2_8_1_96_1
e_1_2_8_1_172_1
e_1_2_8_1_153_1
e_1_2_8_1_16_1
e_1_2_8_1_39_1
e_1_2_8_1_77_1
Chen D. (e_1_2_8_1_7_1) 2013; 29
e_1_2_8_1_130_1
Hundt S. (e_1_2_8_1_36_1) 2008; 31
References_xml – ident: e_1_2_8_1_104_1
  doi: 10.1016/j.ygyno.2008.08.036
– ident: e_1_2_8_1_31_1
  doi: 10.1111/j.1442-2050.2012.01389.x
– ident: e_1_2_8_1_113_1
  doi: 10.3727/096504017X15035025554553
– ident: e_1_2_8_1_77_1
  doi: 10.2174/1381612820666140128213117
– ident: e_1_2_8_1_152_1
  doi: 10.1186/s12885-015-1031-5
– ident: e_1_2_8_1_91_1
  doi: 10.1073/pnas.0804549105
– ident: e_1_2_8_1_9_1
  doi: 10.1016/j.prp.2017.06.006
– ident: e_1_2_8_1_61_1
  doi: 10.3892/ijo.2016.3453
– ident: e_1_2_8_1_131_1
  doi: 10.1186/s40478-014-0173-z
– ident: e_1_2_8_1_44_1
  doi: 10.2174/1389450116666150325231555
– ident: e_1_2_8_1_157_1
  doi: 10.1373/clinchem.2010.147553
– ident: e_1_2_8_1_32_1
  doi: 10.1158/1055-9965.EPI-16-0607
– volume: 14
  start-page: 6097
  issue: 5
  year: 2017
  ident: e_1_2_8_1_27_1
  article-title: MicroRNA‐25 contributes to cisplatin resistance in gastric cancer cells by inhibiting forkhead box O3a
  publication-title: Oncology Letters
– ident: e_1_2_8_1_37_1
  doi: 10.1158/0008-5472.CAN-05-1783
– ident: e_1_2_8_1_26_1
  doi: 10.12659/MSM.897663
– ident: e_1_2_8_1_60_1
  doi: 10.1007/s10620-017-4831-4
– volume: 2
  start-page: 235
  issue: 2
  year: 2009
  ident: e_1_2_8_1_94_1
  article-title: MicroRNA‐21 induces cell proliferation and invasion in esophageal squamous cell carcinoma
  publication-title: Molecular Medicine Reports
– ident: e_1_2_8_1_18_1
  doi: 10.1007/s12032-014-0164-8
– ident: e_1_2_8_1_108_1
  doi: 10.1093/carcin/bgq240
– volume: 127
  start-page: 554
  issue: 3
  year: 2014
  ident: e_1_2_8_1_110_1
  article-title: MicroRNAs are implicated in the initiation and progression of gastric cancer
  publication-title: Chinese Medical Journal
  doi: 10.3760/cma.j.issn.0366-6999.20122918
– ident: e_1_2_8_1_135_1
  doi: 10.1007/s12094-017-1668-4
– ident: e_1_2_8_1_167_1
  doi: 10.3233/CBM-2011-0231
– ident: e_1_2_8_1_2_1
  doi: 10.3390/s120303359
– ident: e_1_2_8_1_24_1
  doi: 10.1007/s11033-012-2267-7
– volume: 41
  start-page: 155
  issue: 1
  year: 2018
  ident: e_1_2_8_1_146_1
  article-title: Histone deacetylase 3 is associated with gastric cancer cell growth via the miR‐454‐mediated targeting of CHD5
  publication-title: International Journal of Molecular Medicine
– ident: e_1_2_8_1_111_1
  doi: 10.1007/s10620-011-1981-7
– ident: e_1_2_8_1_87_1
  doi: 10.1002/ijc.30224
– ident: e_1_2_8_1_10_1
  doi: 10.1093/nar/gki200
– ident: e_1_2_8_1_19_1
  doi: 10.1016/j.ejphar.2016.09.025
– ident: e_1_2_8_1_106_1
  doi: 10.1002/jcb.26271
– volume: 5
  start-page: 1514
  issue: 6
  year: 2012
  ident: e_1_2_8_1_138_1
  article-title: Circulating miR‐17‐5p and miR‐20a: Molecular markers for gastric cancer
  publication-title: Molecular Medicine Reports
– ident: e_1_2_8_1_88_1
  doi: 10.1002/jcp.25799
– ident: e_1_2_8_1_132_1
  doi: 10.1016/j.neulet.2016.10.034
– ident: e_1_2_8_1_79_1
  doi: 10.1002/jcb.26300
– ident: e_1_2_8_1_22_1
  doi: 10.1002/jcp.25793
– ident: e_1_2_8_1_23_1
  doi: 10.1002/jcp.26070
– volume: 6
  start-page: 2713
  issue: 11
  year: 2016
  ident: e_1_2_8_1_160_1
  article-title: Circulating miRNA profile in esophageal adeocarcinoma
  publication-title: American Journal of Cancer Research
– ident: e_1_2_8_1_139_1
  doi: 10.1089/dna.2017.3922
– ident: e_1_2_8_1_162_1
  doi: 10.1186/1756-9966-33-10
– volume: 7
  start-page: 602
  issue: 2
  year: 2014
  ident: e_1_2_8_1_158_1
  article-title: microRNA‐155 acts as an oncogene by targeting the tumor protein 53‐induced nuclear protein 1 in esophageal squamous cell carcinoma
  publication-title: International Journal of Clinical and Experimental Pathology
– ident: e_1_2_8_1_122_1
  doi: 10.1186/s40064-016-2119-3
– ident: e_1_2_8_1_13_1
  doi: 10.1007/978-3-319-01580-4_3
– ident: e_1_2_8_1_109_1
  doi: 10.4103/0973-1482.175428
– ident: e_1_2_8_1_105_1
  doi: 10.1186/1472-6750-7-1
– volume: 39
  start-page: 71
  issue: 1
  year: 2018
  ident: e_1_2_8_1_50_1
  article-title: miR‐486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2
  publication-title: Oncology Reports
– ident: e_1_2_8_1_128_1
  doi: 10.1093/nar/gkr254
– ident: e_1_2_8_1_39_1
  doi: 10.1128/MCB.01977-07
– volume: 29
  start-page: 1181
  issue: 11
  year: 2013
  ident: e_1_2_8_1_7_1
  article-title: Expressions and correlations of let‐7a and IL‐6 in esophageal squamous cell carcinoma
  publication-title: Chinese Journal of Cellular and Molecular Immunology
– ident: e_1_2_8_1_150_1
  doi: 10.1016/j.biopha.2017.08.144
– volume: 5
  start-page: 821
  issue: 2
  year: 2015
  ident: e_1_2_8_1_161_1
  article-title: Hemolysis‐free plasma miR‐214 as novel biomarker of gastric cancer and is correlated with distant metastasis
  publication-title: American Journal of Cancer Research
– ident: e_1_2_8_1_76_1
  doi: 10.1007/s11033-010-0480-9
– volume: 21
  start-page: 3389
  issue: 15
  year: 2017
  ident: e_1_2_8_1_59_1
  article-title: MicroRNA‐124 inhibits cell invasion and epithelial‐mesenchymal transition by directly repressing Snail2 in gastric cancer
  publication-title: European Review for Medical and Pharmacological Sciences
– ident: e_1_2_8_1_66_1
  doi: 10.1111/his.12401
– ident: e_1_2_8_1_5_1
  doi: 10.3390/s120709349
– ident: e_1_2_8_1_116_1
  doi: 10.1016/j.bios.2006.01.006
– ident: e_1_2_8_1_168_1
  doi: 10.1016/j.canlet.2015.07.015
– volume: 8
  year: 2017
  ident: e_1_2_8_1_55_1
  article-title: The miR‐17‐92 cluster as a potential biomarker for the early diagnosis of gastric cancer: Evidence and literature review
  publication-title: Oncotarget
– ident: e_1_2_8_1_95_1
  doi: 10.1002/jcp.25801
– ident: e_1_2_8_1_117_1
  doi: 10.1007/s13277-014-2516-6
– ident: e_1_2_8_1_125_1
  doi: 10.1038/sj.bjc.6605608
– ident: e_1_2_8_1_130_1
  doi: 10.1073/pnas.0510565103
– ident: e_1_2_8_1_127_1
  doi: 10.1016/j.tibs.2016.08.004
– ident: e_1_2_8_1_20_1
  doi: 10.3892/or.2017.5758
– ident: e_1_2_8_1_3_1
  doi: 10.1038/nature02871
– ident: e_1_2_8_1_92_1
  doi: 10.1007/s12038-012-9192-8
– ident: e_1_2_8_1_119_1
  doi: 10.1016/j.bbrc.2016.01.042
– ident: e_1_2_8_1_134_1
  doi: 10.1186/s13000-016-0536-9
– ident: e_1_2_8_1_86_1
  doi: 10.2174/0929867323666160818093854
– ident: e_1_2_8_1_90_1
  doi: 10.1016/j.ejca.2015.10.009
– ident: e_1_2_8_1_164_1
  doi: 10.3892/mmr.2017.6979
– ident: e_1_2_8_1_71_1
  doi: 10.1007/s13277-015-4019-5
– ident: e_1_2_8_1_137_1
  doi: 10.1093/carcin/bgs259
– ident: e_1_2_8_1_69_1
  doi: 10.1371/journal.pone.0033987
– volume: 32
  start-page: 1238
  issue: 9
  year: 2016
  ident: e_1_2_8_1_41_1
  article-title: The expression and significance of miR‐33b and HMGA2 in esophageal squamous cell carcinoma
  publication-title: Chinese Journal of Cellular and Molecular Immunology
– ident: e_1_2_8_1_75_1
  doi: 10.1186/1756-9966-31-38
– ident: e_1_2_8_1_21_1
  doi: 10.2174/1381612822666151112151924
– ident: e_1_2_8_1_51_1
  doi: 10.1111/j.1365-2141.2008.07077.x
– ident: e_1_2_8_1_98_1
  doi: 10.3892/or.2017.5745
– ident: e_1_2_8_1_38_1
  doi: 10.3748/wjg.v20.i19.5694
– ident: e_1_2_8_1_99_1
  doi: 10.3892/ol.2017.6558
– volume: 7
  start-page: 6543
  issue: 10
  year: 2014
  ident: e_1_2_8_1_63_1
  article-title: miR‐101 suppresses tumor proliferation and migration, and induces apoptosis by targeting EZH2 in esophageal cancer cells
  publication-title: International Journal of Clinical and Experimental Pathology
– ident: e_1_2_8_1_170_1
  doi: 10.2147/OTT.S139443
– ident: e_1_2_8_1_172_1
  doi: 10.1007/s10620-013-2970-9
– volume: 33
  start-page: 271
  issue: 1
  year: 2013
  ident: e_1_2_8_1_48_1
  article-title: Prognostic impact of circulating miR‐21 in the plasma of patients with gastric carcinoma
  publication-title: Anticancer Research
– ident: e_1_2_8_1_34_1
  doi: 10.1002/cam4.973
– ident: e_1_2_8_1_47_1
  doi: 10.1038/bjc.2011.198
– ident: e_1_2_8_1_136_1
  doi: 10.1073/pnas.0813371106
– ident: e_1_2_8_1_40_1
  doi: 10.1002/jcp.26379
– ident: e_1_2_8_1_96_1
  doi: 10.1016/j.gene.2012.12.031
– ident: e_1_2_8_1_17_1
  doi: 10.1002/ijc.25516
– volume: 33
  start-page: 5407
  issue: 12
  year: 2013
  ident: e_1_2_8_1_141_1
  article-title: A novel chemotherapeutic arene ruthenium (II) drug Rawq01 altered the effect of microRNA‐21 on PTEN/AKT signaling pathway in esophageal cancer cells
  publication-title: Anticancer Research
– ident: e_1_2_8_1_54_1
  doi: 10.3892/or.2014.3327
– ident: e_1_2_8_1_42_1
  doi: 10.1002/ijc.25284
– ident: e_1_2_8_1_67_1
  doi: 10.1007/s11033-011-0854-7
– ident: e_1_2_8_1_159_1
  doi: 10.7150/thno.10305
– ident: e_1_2_8_1_78_1
  doi: 10.2353/ajpath.2009.080718
– ident: e_1_2_8_1_80_1
  doi: 10.1038/sj.onc.1210425
– ident: e_1_2_8_1_151_1
  doi: 10.3233/CBM-170310
– ident: e_1_2_8_1_8_1
  doi: 10.3892/or.2014.3004
– ident: e_1_2_8_1_6_1
  doi: 10.1002/jcb.26497
– ident: e_1_2_8_1_97_1
  doi: 10.1007/s00432-016-2316-z
– volume: 16
  start-page: 1935
  issue: 10
  year: 2007
  ident: e_1_2_8_1_35_1
  article-title: Blood markers for early detection of colorectal cancer: A systematic review. Cancer Epidemiology and Prevention
  publication-title: Biomarkers
– ident: e_1_2_8_1_15_1
  doi: 10.1056/NEJMra035010
– ident: e_1_2_8_1_81_1
  doi: 10.1186/1476-4598-5-24
– ident: e_1_2_8_1_85_1
  doi: 10.2174/1381612822666160303110838
– ident: e_1_2_8_1_73_1
  doi: 10.7314/APJCP.2013.14.12.7551
– ident: e_1_2_8_1_115_1
  doi: 10.3892/mmr.2017.7758
– ident: e_1_2_8_1_121_1
  doi: 10.1158/0008-5472.CAN-16-0359
– ident: e_1_2_8_1_140_1
  doi: 10.1186/1479-5876-11-301
– ident: e_1_2_8_1_4_1
  doi: 10.1002/jcb.26244
– ident: e_1_2_8_1_70_1
  doi: 10.1155/2014/931083
– ident: e_1_2_8_1_12_1
  doi: 10.18632/oncotarget.6499
– volume: 18
  start-page: 524
  issue: 8
  year: 2015
  ident: e_1_2_8_1_43_1
  article-title: MicroRNA‐21: Mechanisms of oncogenesis and its application in diagnosis and prognosis of gastric cancer
  publication-title: Archives of Iranian Medicine
– ident: e_1_2_8_1_82_1
  doi: 10.1002/jcb.26130
– ident: e_1_2_8_1_14_1
  doi: 10.1371/journal.pone.0115589
– ident: e_1_2_8_1_89_1
  doi: 10.1002/jcp.25787
– ident: e_1_2_8_1_123_1
  doi: 10.1002/jcb.26599
– ident: e_1_2_8_1_45_1
  doi: 10.1016/j.jmoldx.2013.04.004
– ident: e_1_2_8_1_120_1
  doi: 10.3233/CBM-150564
– ident: e_1_2_8_1_53_1
  doi: 10.3727/096504017X14847395834985
– volume: 31
  start-page: 65
  year: 2008
  ident: e_1_2_8_1_36_1
  article-title: Blood markers for early detection of colorectal cancer. A systematic review
  publication-title: Onkologie
– ident: e_1_2_8_1_155_1
  doi: 10.1371/journal.pone.0073278
– ident: e_1_2_8_1_83_1
  doi: 10.4103/0973-1482.153661
– ident: e_1_2_8_1_72_1
  doi: 10.1038/onc.2008.256
– ident: e_1_2_8_1_169_1
  doi: 10.1007/s00109-010-0617-2
– ident: e_1_2_8_1_93_1
  doi: 10.2217/pgs-2018-0197
– ident: e_1_2_8_1_129_1
  doi: 10.1038/onc.2012.506
– ident: e_1_2_8_1_30_1
  doi: 10.1002/ijc.28757
– ident: e_1_2_8_1_33_1
  doi: 10.1186/1476-4598-11-51
– ident: e_1_2_8_1_144_1
  doi: 10.1002/jcb.26413
– ident: e_1_2_8_1_102_1
  doi: 10.1016/j.biopha.2017.01.161
– ident: e_1_2_8_1_49_1
  doi: 10.1038/bjc.2011.588
– ident: e_1_2_8_1_74_1
  doi: 10.1016/j.canlet.2017.04.006
– ident: e_1_2_8_1_153_1
  doi: 10.2174/1871520615666150716110657
– ident: e_1_2_8_1_52_1
  doi: 10.1038/onc.2017.29
– ident: e_1_2_8_1_145_1
  doi: 10.3748/wjg.v20.i22.6906
– ident: e_1_2_8_1_124_1
  doi: 10.1155/2015/731479
– ident: e_1_2_8_1_156_1
  doi: 10.3892/or.2012.1645
– ident: e_1_2_8_1_100_1
  doi: 10.1002/jcb.26146
– ident: e_1_2_8_1_68_1
  doi: 10.1016/j.ejca.2010.10.025
– ident: e_1_2_8_1_107_1
  doi: 10.1186/s12943-015-0473-3
– ident: e_1_2_8_1_84_1
  doi: 10.1016/bs.acc.2017.06.004
– ident: e_1_2_8_1_165_1
  doi: 10.1042/CS20110207
– ident: e_1_2_8_1_126_1
  doi: 10.1007/s10120-014-0363-1
– ident: e_1_2_8_1_143_1
  doi: 10.1002/path.4030
– ident: e_1_2_8_1_147_1
  doi: 10.1016/j.canlet.2017.11.007
– year: 2017
  ident: e_1_2_8_1_56_1
  article-title: miR‐21 modulates prostaglandin signaling and promotes gastric tumorigenesis by targeting 15‐PGDH
  publication-title: Biochemical and Biophysical Research Communications
– ident: e_1_2_8_1_101_1
  doi: 10.1002/jcp.25738
– ident: e_1_2_8_1_142_1
  doi: 10.1155/2015/435656
– volume: 8
  start-page: 8048
  issue: 7
  year: 2015
  ident: e_1_2_8_1_58_1
  article-title: Mir‐192 suppresses apoptosis and promotes proliferation in esophageal aquamous cell caicinoma by targeting bim
  publication-title: International Journal of Clinical and Experimental Pathology
– ident: e_1_2_8_1_163_1
  doi: 10.1007/s10620-014-3433-7
– ident: e_1_2_8_1_149_1
  doi: 10.1002/ijc.25506
– ident: e_1_2_8_1_112_1
  doi: 10.3892/ol.2013.1626
– ident: e_1_2_8_1_29_1
  doi: 10.1002/jcp.25930
– ident: e_1_2_8_1_114_1
  doi: 10.1371/journal.pone.0033608
– ident: e_1_2_8_1_118_1
  doi: 10.1158/1078-0432.CCR-12-0701
– volume: 6
  start-page: 1511
  issue: 7
  year: 2016
  ident: e_1_2_8_1_46_1
  article-title: Circulating miR‐21 as an independent predictive biomarker for chemoresistance in esophageal squamous cell carcinoma
  publication-title: American Journal of Cancer Research
– volume: 17
  start-page: 602
  issue: 1
  year: 2018
  ident: e_1_2_8_1_62_1
  article-title: MicroRNA‐197 inhibits gastric cancer progression by directly targeting metadherin
  publication-title: Molecular Medicine Reports
– ident: e_1_2_8_1_171_1
  doi: 10.3892/ol.2017.6777
– ident: e_1_2_8_1_28_1
  doi: 10.1158/1078-0432.CCR-08-2545
– ident: e_1_2_8_1_65_1
  doi: 10.1016/j.jgg.2015.09.010
– ident: e_1_2_8_1_103_1
  doi: 10.1038/bjc.2014.485
– volume: 2
  start-page: 3
  year: 2011
  ident: e_1_2_8_1_154_1
  article-title: Proteomic analysis of gene expression during human esophagus cancer
  publication-title: Journal of Paramedical Sciences
– ident: e_1_2_8_1_11_1
  doi: 10.1373/clinchem.2007.097972
– ident: e_1_2_8_1_16_1
  doi: 10.1038/cgt.2016.52
– ident: e_1_2_8_1_57_1
  doi: 10.1007/s10620-013-2854-z
– ident: e_1_2_8_1_64_1
  doi: 10.1016/j.canlet.2011.10.034
– ident: e_1_2_8_1_148_1
  doi: 10.3892/etm.2017.4798
– ident: e_1_2_8_1_133_1
  doi: 10.1007/s00432-012-1244-9
– volume: 21
  start-page: 4071
  issue: 18
  year: 2017
  ident: e_1_2_8_1_166_1
  article-title: Upregulation of miR‐802 suppresses gastric cancer oncogenicity via targeting RAB23 expression
  publication-title: European Review for Medical and Pharmacological Sciences
– ident: e_1_2_8_1_25_1
  doi: 10.1038/ncomms3544
SSID ssj0009933
Score 2.589402
SecondaryResourceType review_article
Snippet Gastric and esophageal cancers are as main cancers of the gastrointestinal (GI) tract, which are associated with poor diagnosis and survival. Several efforts...
SourceID proquest
pubmed
crossref
wiley
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 8538
SubjectTerms Biomarkers
Cancer
Deregulation
Diagnosis
Diagnostic systems
esophagal cancer
Esophageal cancer
Esophagus
Gastric cancer
gastric carcinogenesis
Gastrointestinal tract
Gene expression
mechanisms
microRNA (miRNA)
MicroRNAs
miRNA
Ribonucleic acid
RNA
Tumors
Title Circulating microRNAs as diagnostic and therapeutic biomarkers in gastric and esophageal cancers
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjcp.26850
https://www.ncbi.nlm.nih.gov/pubmed/29923196
https://www.proquest.com/docview/2114852354
https://www.proquest.com/docview/2057439391
Volume 233
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fa9RAEB6OguBLq621p1VWEenLXZPNJtng03FYSsFDigf3IMT9ldLWpuVy91D_emd2k9RqBfEtkEl2s7Oz-81m5huAdyItuFZoSHklkpFIYzmSFoFcWiidcWlVFVE28qdZdjwXJ4t0MYAPXS5M4IfoD9zIMvx6TQaudHN4Rxp6YW7GPJPeX6dYLQJEp3fUUUVbRt6HIKQi7liFIn7YP3l_L_oDYN7Hq37DOdqCr11XQ5zJ5Xi90mPz4zcWx__8liew2QJRNgkz5ykMXL0NO5ManfCrW_ae-dBQf-a-DY9CxcrbHfg2PV8aX_GrPmNXFMx3Ops0TDXMhpg9fBtTtWW_5HUxSvGnKKBlw85rdqaoVEiQclREAVc07Iih6bdsnsH86OOX6fGoLdIwMoLS0HOd8EpmqOpciUrFxupYEK-cNLpKOWofAZeMHC4mVkqXG2cyW0Wx5SpxhTPJLmzU17XbA4bQIdWRy2zsI1tdYRMhI60yoZMqT_IhHHTqKk3LYE6FNL6XgXuZlziOpR_HIbztRW8CbcdDQvudzsvWcpuSk4OI3nkqhvCmv402Rz9SVO2u1yiDIBeBXFLEQ3ge5krfCm7vnJY17KzX-N-bL0-mn_3Fi38XfQmPEbHJkAy5Dxur5dq9QlS00q_99P8JQpkGvQ
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5VRQguPFoeCwUMQojLbhPHSRyJy2qhWkq7QlUr9YKCX6na0rTa7B7Kr2fGTlLKQ0LcImUSO_bM-LMz8w3Aa5EWXCs0pLwSyVCksRxKi0AuLZTOuLSqiigbeXeWTQ_E9mF6uALvulyYwA_RH7iRZXh_TQZOB9KbV6yhJ-ZixDNJG_YbVNGbmPPf712RRxVtIXkfhJCKuOMVivhm_-j11eg3iHkdsfolZ-sufOk6GyJNTkfLhR6Z77_wOP7v19yDOy0WZeOgPPdhxdVrsD6ucR9-dsneMB8d6o_d1-BmKFp5uQ5fJ8dz44t-1UfsjOL59mbjhqmG2RC2h29jqrbsp9QuRln-FAg0b9hxzY4UVQsJUo7qKKBTw44Y0sB58wAOtj7sT6bDtk7D0AjKRM91wiuZ4WznSlQqNlbHgqjlpNFVylEBEHPJyKE_sVK63DiT2SqKLVeJK5xJHsJqfV67x8AQPaQ6cpmNfXCrK2wiZKRVJnRS5Uk-gLfdfJWmJTGnWhrfykC_zEscx9KP4wBe9aIXgbnjT0Ib3aSXrfE2Jac9Im7QUzGAl_1tNDv6l6Jqd75EGcS5iOWSIh7Ao6AsfSu4wnPybNhZP-V_b77cnnz2F0_-XfQF3Jru7-6UOx9nn57CbQRwMuRGbsDqYr50zxAkLfRzbws_AKdiCtk
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5VRSAuPFoeCwUMQojLbhPHSRxxWm1ZlQKrqqJSD0ipX6kKNF1tdg_l1zNjJynlISFukTKJHY_H_saZ-QbgpUgLrhUaUl6JZCjSWA6lRSCXFkpnXFpVRZSN_HGW7R6KvaP0aA3edLkwgR-iP3Ajy_DrNRn43Fbbl6ShX8x8xDNJ_vo1kUUF1W3YObjkjiraOvI-BiEVcUcrFPHt_tGrm9FvCPMqYPU7zvQ2fO76GgJNvo5WSz0y33-hcfzPj7kDt1okysZh6tyFNVdvwOa4Ri_87IK9Yj421B-6b8D1ULLyYhOOJ6cL40t-1SfsjKL5DmbjhqmG2RC0h29jqrbsp8QuRjn-FAa0aNhpzU4U1QoJUo6qKOCShh0xNP8WzT04nL79NNkdtlUahkZQHnquE17JDHWdK1Gp2FgdCyKWk0ZXKUf1I-KSkcPVxErpcuNMZqsotlwlrnAmuQ_r9XntHgJD7JDqyGU29qGtrrCJkJFWmdBJlSf5AF536ipNS2FOlTS-lYF8mZc4jqUfxwG86EXngbfjT0Jbnc7L1nSbkpOHiO55KgbwvL-NRkd_UlTtzlcogygXkVxSxAN4EOZK3wru75zWNeys1_jfmy_3Jvv-4tG_iz6DG_s70_LDu9n7x3AT0ZsMiZFbsL5crNwTREhL_dRbwg9_zQmI
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Circulating+microRNAs+as+diagnostic+and+therapeutic+biomarkers+in+gastric+and+esophageal+cancers&rft.jtitle=Journal+of+cellular+physiology&rft.au=Jamali%2C+Leila&rft.au=Tofigh%2C+Roghayeh&rft.au=Tutunchi%2C+Sara&rft.au=Panahi%2C+Ghodratollah&rft.date=2018-11-01&rft.issn=0021-9541&rft.eissn=1097-4652&rft.volume=233&rft.issue=11&rft.spage=8538&rft.epage=8550&rft_id=info:doi/10.1002%2Fjcp.26850&rft.externalDBID=10.1002%252Fjcp.26850&rft.externalDocID=JCP26850
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9541&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9541&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9541&client=summon